Oncology · Phase I Pipeline

Quick answer

Oncology Phase I programs: NovaPharmaNews indexes 1,319 matching clinical development programs from ClinicalTrials.gov with sponsor, modality, and NCT cross-links.

Top sponsors

Pipeline programs

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TVB-2640

Sagimet Biosciences

Solid Malignant Tumor

phase 1 small molecule completed

1 trial
TYR200-101

Tyra Biosciences

Locally Advanced Cholangiocarcinoma

phase 1 small molecule active

1 trial
TYRA-430

Tyra Biosciences

Metastatic Hepatocellular Carcinoma

phase 1 small molecule active

1 trial
Ta-NPs (2% Tumor Volume)

Xiyuan Hospital of China Academy of Chinese Medical Sciences

Locally Recurrent Retroperitoneal Soft Tissue Sarcoma

phase 1 mab active

1 trial
Talabostat Mesylate

BioXcel Therapeutics

Cancer of Pancreas

phase 1 small molecule terminated

1 trial
Talazoparib

BioMarin Pharmaceutical Australia Pty Ltd

Childhood Solid Tumors

phase 1 small molecule completed

1 trial
Target CD7 CAR-T cells

Xiyuan Hospital of China Academy of Chinese Medical Sciences

T-cell Acute Lymphoblastic Leukemia

phase 1 mab terminated

1 trial
Targeted CEA CAR-T

Chongqing Precision Biotech Co., Ltd

Advanced Lung Cancer

phase 1 mab active

4 trials
Tarlatamab

BEONE MEDICINES AUS PTY LTD

Extensive Stage Small Cell Lung Cancer

phase 1 small molecule active

1 trial
Tarlatamab

Amgen

Neuroendocrine Prostate Cancer

phase 1 small molecule completed

1 trial
Tcrx T cell

TScan Therapeutics

Gastric Cancer

phase 1 mab active

1 trial
Tecartus 0.4 - 2 x 10e8 cells dispersion for infusion

Lacuna Pharma Pty Ltd

Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (r/r ALL) Relapsed/Refractory B-cell non-Hodgkin lymphoma (r/r NHL)

phase 1 small molecule active

1 trial
Tepotinib

United Therapeutics Europe Ltd

Advanced Cancer

phase 1 small molecule active

1 trial
The Chimeric Antigen Receptor T Cell Immunotherapy (CAR-T)

Sinobioway Cell Therapy Co.,

Lymphoma

phase 1 mab active

1 trial
The TILS001 trial

The George Institute

advanced or metastasic triple-negative breast cancer

phase 1 other active

1 trial
ThisCART19A

The First People's Hospital of Lianyungang

Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

phase 1 small molecule active

1 trial
ThisCART7 cells

Xiyuan Hospital of China Academy of Chinese Medical Sciences

T-Acute Lymphoblastic Leukemia

phase 1 mab active

1 trial
Tipifarnib

Kura Oncology

Advanced Solid Tumor

phase 1 small molecule terminated

1 trial
Trastuzumab

Hoffmann-La Roche

Early Breast Cancer

phase 1 small molecule completed

1 trial
Trastuzumab Deruxtecan

Daiichi Sankyo

Recurrent or Metastatic Solid Tumors

phase 1 small molecule active

1 trial
Trebananib 3 mg/kg

Takeda

Neoplasms, Advanced Solid

phase 1 small molecule completed

1 trial
Trial of the novel peroral anti-tumor treatment in patients with solid tumors

Lacuna Pharma Pty Ltd

Metastatic or locally advanced solid tumors for which no standard therapy exists or standard therapy has failed: tumors of lung, head and neck, colon, stomach, esophagus, breast, ovary and/or fallopian tube or primary peritoneal high-grade serous carcinoma

phase 1 other active

1 trial
Triprorelin for injection

The First People's Hospital of Lianyungang

Prostate Cancer (CRPC)

phase 1 small molecule active

1 trial
U96

The First People's Hospital of Lianyungang

Relapsed or Refractory B Cell Leukemia and Lymphoma

phase 1 small molecule active

1 trial
UB-921

United Therapeutics Europe Ltd

Breast Neoplasm

phase 1 mab completed

1 trial
UHKT-CAR19-01

The George Institute

Relapsed/refractory CD19+ Acute Lymphoblastic Leukaemia and Non-Hodgkin Lymphoma

phase 1 other active

1 trial
UMCG-NEOLYNC-001

Disc Medicine

Cervical Cancer

phase 1 other active

1 trial
UR001

Lacuna Pharma Pty Ltd

Non-muscle Invasive Bladder Cancer

phase 1 other active

1 trial
UTAA09 injection

The First People's Hospital of Lianyungang

Recurrent or Refractory B-cell Non Hodgkin's Lymphoma

phase 1 mab active

1 trial
Ublituximab + TGR-1202

TG THERAPEUTICS, INC.

Chronic Lymphocytic Leukemia

phase 1 small molecule completed

1 trial
Unesbulin

PTC THERAPEUTICS, INC.

Ovarian Cancer

phase 1 small molecule completed

1 trial
VAR2-2024-CS01

Lacuna Pharma Pty Ltd

Multiple solid tumors including: colorectal carcinoma (CRC), pancreatic carcinoma, oesophageal or gastric carcinoma, head and neck squamous cell carcinoma (HNSCC), chondrosarcoma or osteosarcoma, bladder carcinoma, lung carcinoma and glioblastoma.

phase 1 other active

1 trial
VEGF inhibitor PTC299

PTC THERAPEUTICS, INC.

Brain and Central Nervous System Tumors

phase 1 small molecule completed

1 trial
VHIO20001

The George Institute

Advanced epithelial tumors and immune checkpoint blockade (ICB) resistant solid tumors

phase 1 other active

1 trial
VHIO20002

The George Institute

Refractory metastatic Her2 positive breast cancer

phase 1 other active

1 trial
VHIO24001

The George Institute

Locally advanced, recurrent, or metastatic breast, gastric, endometrial, and selected other solid tumors with positive expression for HER-2 (3+)

phase 1 other active

1 trial
VHIO24001

The George Institute

Locally advanced, recurrent, or metastatic breast, gastric, endometrial, and selected other solid tumors with positive expression for HER-2 (3+)

phase 1 other active

1 trial
VIR-5500

Vir Biotechnology

Hormone-refractory Prostate Cancer

phase 1 small molecule active

1 trial
VIR-5525

Vir Biotechnology

Solid Tumor Malignancies

phase 1 small molecule active

1 trial
VIR-5818-V101

Vir Biotechnology

Participants with Locally Advanced or Metastatic HER2-Expressing Cancers

phase 1 other active

1 trial
VX15/2503

VACCINEX, INC.

Solid Tumors

phase 1 small molecule completed

1 trial
VX15/2503

VACCINEX, INC.

Squamous Cell Carcinoma of the Head and Neck

phase 1 mab active

1 trial
Vantictumab

Mereo BioPharma Group plc

Pancreatic Cancer

phase 1 small molecule completed

1 trial
Vantictumab combined with paclitaxel

Mereo BioPharma Group plc

Metastatic Breast Cancer

phase 1 small molecule completed

1 trial
Vemurafenib Oral Tablet [Zelboraf]

Xiyuan Hospital of China Academy of Chinese Medical Sciences

BRAF V600E-mutated /MSS Metastatic Colorectal Cancer

phase 1 small molecule active

1 trial
Venetoclax

Karyopharm Therapeutics Inc

Diffuse Large B-cell Lymphoma

phase 1 small molecule completed

1 trial
Venetoclax

Kura Oncology

Acute Myeloid Leukemia

phase 1 small molecule active

1 trial
Venetoclax

Karyopharm Therapeutics Inc

Acute Leukemia of Ambiguous Lineage in Relapse

phase 1 small molecule active

1 trial

Frequently asked questions

How many oncology Phase I programs exist?

1,319 programs match both the therapeutic area and stage filters in our published index.

Quick answer

Top sponsors

Pipeline programs

TVB-2640

TYR200-101

TYRA-430

Ta-NPs (2% Tumor Volume)

Talabostat Mesylate

Talazoparib

Target CD7 CAR-T cells

Targeted CEA CAR-T

Tarlatamab

Tarlatamab

Tcrx T cell

Tecartus 0.4 - 2 x 10e8 cells dispersion for infusion

Tepotinib

The Chimeric Antigen Receptor T Cell Immunotherapy (CAR-T)

The TILS001 trial

ThisCART19A

ThisCART7 cells

Tipifarnib

Trastuzumab

Trastuzumab Deruxtecan

Trebananib 3 mg/kg

Trial of the novel peroral anti-tumor treatment in patients with solid tumors

Triprorelin for injection

U96

UB-921

UHKT-CAR19-01

UMCG-NEOLYNC-001

UR001

UTAA09 injection

Ublituximab + TGR-1202

Unesbulin

VAR2-2024-CS01

VEGF inhibitor PTC299

VHIO20001

VHIO20002

VHIO24001

VHIO24001

VIR-5500

VIR-5525

VIR-5818-V101

VX15/2503

VX15/2503

Vantictumab

Vantictumab combined with paclitaxel

Vemurafenib Oral Tablet [Zelboraf]

Venetoclax

Venetoclax

Venetoclax

Frequently asked questions

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