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Oncology · Phase I

Oncology programs at Phase I — ClinicalTrials.gov pipeline intelligence.

Programs
1,344

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Oncology Phase I programs: NovaPharmaNews indexes 1,344 matching clinical development programs from ClinicalTrials.gov with sponsor, modality, and NCT cross-links.

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  1. Phase 1b Study of Dato-DXd in Combination with Pembrolizumab with or without Platinum Chemotherapy in Advanced or Metastatic Non-Small Cell Lung Cancer

    Daiichi Sankyo

    Non-small cell lung cancer

    phase 1 other active

    1 trial

  2. Phase 1b Study of Tarlatamab + ZL-1310 +/- Anti-PD-L1 in Small Cell Lung Cancer

    Amgen

    Small Cell Lung Cancer

    phase 1 other active

    1 trial

  3. Phase 1b Study of Tarlatamab in Combination with YL201 with or without Anti-PD-L1 in Subjects with Extensive Stage Small Cell Lung Cancer (DeLLphi-310)

    Amgen

    Extensive Stage Small Cell Lung Cancer (ES-SCLC)

    phase 1 other active

    1 trial

  4. Phase 1b safety study of xevinapant, weekly cisplatin, and radiotherapy in participants with unresected LA SCCHN

    Merck Sharp and Dohme

    Locally Advanced Squamous Cell Carcinoma of the Head and Neck

    phase 1 other active

    1 trial

  5. Phase I Clinical Study to Assess Safety and Efficacy of Repotrectinib Combined with Osimertinib in Patients with Advanced, Metastatic EGFR Mutant NSCLC (TOTEM).

    The George Institute

    Non-small cell lung cancer (NSCLC)

    phase 1 other active

    1 trial

  6. Phase I Study of PM54 Administered to Patients with Advanced Solid Tumors

    Lacuna Pharma Pty Ltd

    Selected Advanced Solid Tumors

    phase 1 other active

    1 trial

  7. Phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of [177Lu]Lu-NNS309 in patients with pancreatic, lung, breast and colorectal cancers.

    Novartis Pharmaceuticals

    Locally advanced or metastatic unresectable colorectal cancer (CRC), Locally advanced unresectable or metastatic breast cancer (BC), Locally advanced unresectable or metastatic non-small cell lung cancer (NSCLC), Locally advanced unresectable or metastatic pancreatic ductal adenocarcinoma (PDAC)

    phase 1 other active

    1 trial

  8. Phase I study of 225Ac-PSMA I&T in prostate cancer

    Disc Medicine

    metastatic prostate cancer

    phase 1 other active

    1 trial

  9. Phase I study of IAG933 in patients with advanced Mesothelioma and other solid tumors

    Novartis Pharmaceuticals

    Advanced mesothelioma or other solid tumors harboring certain molecular alterations in the Hippo pathway

    phase 1 other active

    1 trial

  10. Phase I study of MGY825 in patients with lung cancer

    Novartis Pharmaceuticals

    Advanced non-small cell lung cancer with or without NFE2L2/KEAP1/CUL3 mutations in adult patients

    phase 1 other active

    1 trial

  11. Phase IB Study to Assess the Safety, Tolerability and Efficacy of PM14 in combination with Atezolizumab in Pretreated Patients with Selected Advanced Solid Tumors

    Lacuna Pharma Pty Ltd

    Advanced solid tumors

    phase 1 other active

    1 trial

  12. Pilot Study on Subcutaneously Administered Immunotherapy for the Treatment of Cervical Cancer

    Disc Medicine

    Cervical Cancer

    phase 1 other active

    1 trial

  13. Pitavastatin

    United Therapeutics Europe Ltd

    Acute Myeloid Leukemia

    phase 1 small molecule completed

    1 trial

  14. Placebo for antibiotic

    Seres Therapeutics

    Metastatic Melanoma

    phase 1 small molecule completed

    1 trial

  15. Plerixafor

    United Therapeutics Europe Ltd

    Pancreatic Adenocarcinoma Metastatic

    phase 1 small molecule completed

    1 trial

  16. Pluvicto 1 000 MBq/mL solution for injection/infusion, Lutetium (177Lu) rhPSMA-10.1 injection

    Blue Earth Diagnostics Ireland Ltd

    PSMA-positive non-curative metastatic castration-resistant prostate cancer

    phase 1 small molecule active

    1 trial

  17. Ponatinib

    Takeda

    Chronic Myelogenous Leukemia

    phase 1 small molecule completed

    1 trial

  18. Prizloncabtagene Autoleucel

    The First People's Hospital of Lianyungang

    Non-Hodgkin's B-cell Lymphoma

    phase 1 mab active

    1 trial

  19. Prospective feasibility pilot study evaluating the value of [68Ga]Ga-PENTIXAFOR PET-CT in patients with locally advanced or metastatic Small Cell Lung Cancer (SCLC) at diagnosis and disease progression (PASSIFLORE)

    CERO THERAPEUTICS HOLDINGS, INC.

    cell lung carcinoma

    phase 1 other active

    1 trial

  20. Proxalutamide

    The First People's Hospital of Lianyungang

    Metastatic Breast Cancer

    phase 1 small molecule completed

    1 trial

  21. Pyrotinib low dose group

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Breast Cancer

    phase 1 small molecule active

    1 trial

  22. QEQ278

    Novartis Pharmaceuticals

    Carcinoma, Non-Small-Cell Lung

    phase 1 mab terminated

    1 trial

  23. RAD 001 in combination with Caelyx

    BRIGHT MINDS BIOSCIENCES INC.

    Advanced Solid Tumors

    phase 1 small molecule active

    1 trial

  24. RBL001/RBL002

    Atrium Therapeutics

    Melanoma

    phase 1 mab completed

    1 trial

  25. REGN1400

    Regeneron UK Limited

    Cancer

    phase 1 small molecule completed

    1 trial

  26. REGN2810

    Regeneron UK Limited

    Melanoma

    phase 1 small molecule completed

    1 trial

  27. REGN2810

    Regeneron UK Limited

    Recurrent Squamous Cell Carcinoma of Head

    phase 1 small molecule completed

    1 trial

  28. REGN4659

    Regeneron UK Limited

    Carcinoma, Non-Small-Cell Lung

    phase 1 small molecule terminated

    1 trial

  29. REGN5678

    Regeneron UK Limited

    Prostate Cancer

    phase 1 small molecule active

    1 trial

  30. REGN6569

    Regeneron UK Limited

    Squamous Cell Carcinoma of Head and Neck

    phase 1 small molecule terminated

    1 trial

  31. REOLYSIN®

    ONCOLYTICS BIOTECH INC

    KRAS Mutant Metastatic Colorectal Cancer

    phase 1 mab completed

    1 trial

  32. REOLYSIN®

    ONCOLYTICS BIOTECH INC

    Muscle-invasive Transitional Cell Carcinoma of the Bladder

    phase 1 mab terminated

    1 trial

  33. REOLYSIN®

    ONCOLYTICS BIOTECH INC

    Pancreatic Adenocarcinoma

    phase 1 mab completed

    1 trial

  34. RESTART; Autologous Transplantation of Adult Salivary Gland Stem Cells to Restore Submandibular Gland Function after Radiotherapy

    Disc Medicine

    Patients operated with curative intend for head and neck cancer with an indication for bilateral postoperative radiotherapy, with or without chemotherapy.

    phase 1 other active

    1 trial

  35. RJMty19 (CD19-CAR-DNT cells)

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    B-cell Non-Hodgkin's Lymphoma

    phase 1 mab active

    1 trial

  36. RMC-4630

    Revolution Medicines

    Solid Tumors

    phase 1 small molecule active

    1 trial

  37. RMC-5127

    Revolution Medicines

    Non-small Cell Lung Cancer (NSCLC)

    phase 1 small molecule active

    1 trial

  38. RMC-5552

    Revolution Medicines

    Solid Tumors

    phase 1 small molecule completed

    1 trial

  39. RMC-6291

    Revolution Medicines

    Non-Small Cell Lung Cancer (NSCLC)

    phase 1 small molecule active

    2 trials

  40. RMC-9805

    Revolution Medicines

    Non-small Cell Lung Cancer (NSCLC)

    phase 1 small molecule active

    1 trial

  41. RO5323441

    Hoffmann-La Roche

    Carcinoma, Hepatocellular

    phase 1 small molecule completed

    1 trial

  42. RO5503781

    Hoffmann-La Roche

    Neoplasms

    phase 1 small molecule completed

    1 trial

  43. RO5503781 MBP

    Hoffmann-La Roche

    Myelogenous Leukemia, Acute

    phase 1 small molecule completed

    1 trial

  44. RO7119929

    Hoffmann-La Roche

    Carcinoma, Hepatocellular

    phase 1 small molecule completed

    1 trial

  45. Radiation: 18F-AlF-FAPi-04

    Sichuan Provincial People's Hospital

    Tumor, Solid

    phase 1 small molecule active

    1 trial

  46. Recombinant human arginase 1 Peg5000

    International Peace Maternity and Child Health Hospital

    Leukemia

    phase 1 small molecule terminated

    1 trial

  47. Recombinant oncolytic herpes simplex virus type Ⅰ (R130)

    Shanghai University of Traditional Chinese Medicine

    Osteosarcoma

    phase 1 small molecule active

    1 trial

  48. Refametinib (BAY86-9766)

    Bayer HealthCare AG

    Neoplasms

    phase 1 small molecule completed

    1 trial

Frequently asked questions

How many oncology Phase I programs exist?

1,344 programs match both the therapeutic area and stage filters in our published index.

Data attribution: Data sources · All pipeline programs

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