Neurology & CNS · Phase I

Top sponsors

• Anaxis Pharma 10 programs
• Takeda 10 programs
• BRIGHT MINDS BIOSCIENCES 9 programs
• NEUROCRINE BIOSCIENCES 7 programs
• HOFFMANN-LA ROCHE 6 programs
• Chinese Academy of 5 programs
• Alnylam Netherlands 4 programs
• Denali Therapeutics 4 programs
• IONIS PHARMACEUTICALS 4 programs
• Ultragenyx UK 4 programs
• United Therapeutics Europe 4 programs
• SUPERNUS PHARMACEUTICALS 3 programs

1. Placebo

   Jazz Pharmaceuticals Ireland Limited

   Epilepsy

   phase 1 · small molecule · completed

   1 trial →

2. Pramipexole

   United Therapeutics Europe Ltd

   Parkinson Disease

   phase 1 · small molecule · completed

   1 trial →

3. RAP-219-103

   Rapport Therapeutics

   Epilepsy

   phase 1 · other · active

   1 trial →

4. Risperidone

   The First People's Hospital of Lianyungang

   Schizophrenia

   phase 1 · small molecule · active

   1 trial →

5. Roflumilast

   Takeda

   Schizophrenia

   phase 1 · small molecule · completed

   1 trial →

6. SAM-315

   Wyeth is now a wholly owned subsidiary of Pfizer

   Alzheimer Disease

   phase 1 · small molecule · completed

   1 trial →

7. SER-214

   Serina Therapeutics

   Parkinson's Disease

   phase 1 · small molecule · active

   1 trial →

8. SER-252 (PEOZ-apomorphine)

   Serina Therapeutics

   PARKINSON DISEASE (Disorder)

   phase 1 · small molecule · active

   1 trial →

9. SPD489 (Lisdexamfetamine dimesylate)

   Takeda

   Schizophrenia

   phase 1 · small molecule · completed

   1 trial →

10. SPN-804O

    SUPERNUS PHARMACEUTICALS, INC.

    Epilepsies, Partial

    phase 1 · small molecule · completed

    1 trial →

11. Safety for A Phase 1, Randomized, Double-B…

    Lacuna Pharma Pty Ltd

    A Phase 1, Randomized, Double-Blind, Placebo-Controlled, First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Ascending Doses and Food Effect of Leucettinib-21 in Healthy Male Subjects, followed by an open single dose of Leucettinib-21 in Down Syndrome individuals, and patients with Alzheimer’s disease

    phase 1 · other · active

    1 trial →

12. Stem Cell

    EuroGen Pharmaceuticals Ltd

    Neurological; Disorder, Nervous System

    phase 1 · mab · terminated

    1 trial →

13. TAK-058

    Takeda

    Schizophrenia

    phase 1 · small molecule · terminated

    1 trial →

14. TAK-063

    Takeda

    Schizophrenia

    phase 1 · small molecule · completed

    1 trial →

15. TAK-071

    Takeda

    Alzheimer Disease

    phase 1 · small molecule · terminated

    1 trial →

16. TAK-831 Oral Suspension

    NEUROCRINE BIOSCIENCES INC

    Schizophrenia, Cerebellar Ataxia

    phase 1 · small molecule · terminated

    1 trial →

17. TAK-935

    Takeda

    Epilepsy, Molecular Mechanisms of Pharmalogical Action, Protective Agents

    phase 1 · small molecule · completed

    1 trial →

18. TG1101-RMS-SC101

    TG THERAPEUTICS, INC.

    Relapsing multiple sclerosis, Myasthenia Gravis

    phase 1 · small molecule · active

    1 trial →

19. TTP4000

    vTv Therapeutics

    Alzheimer's Disease

    phase 1 · small molecule · completed

    1 trial →

20. TV44749-BA-10196

    Lacuna Pharma Pty Ltd

    Schizophrenia

    phase 1 · other · active

    1 trial →

21. Topiramate IR

    SUPERNUS PHARMACEUTICALS, INC.

    Epilepsy

    phase 1 · small molecule · completed

    1 trial →

22. UB-312

    BRIGHT MINDS BIOSCIENCES INC.

    Parkinson's Disease

    phase 1 · mab · completed

    1 trial →

23. UECHUP-DON/23-5

    Laboratorios Tillomed Spain S.L.U

    Alzheimer's disease

    phase 1 · other · active

    1 trial →

24. UECHUP-MEM/25-6

    Laboratorios Tillomed Spain S.L.U

    Alzheimer’s disease

    phase 1 · other · active

    1 trial →

25. UECHUP-RAS/24-2

    Laboratorios Tillomed Spain S.L.U

    Parkinson´s disease

    phase 1 · other · active

    1 trial →

26. UX-GIP001

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Epilepsy

    phase 1 · small molecule · active

    1 trial →

27. VHX-896 and iloperidone

    Vanda Pharmaceuticals Netherlands B.V.

    Schizophrenia

    phase 1 · small molecule · completed

    1 trial →

28. VX15/2503

    VACCINEX, INC.

    Multiple Sclerosis

    phase 1 · small molecule · completed

    1 trial →

29. VY-AADC01

    NEUROCRINE BIOSCIENCES INC

    Parkinson's Disease

    phase 1 · mab · completed

    1 trial →

30. VY-AADC01

    NEUROCRINE BIOSCIENCES INC

    Idiopathic Parkinson's Disease

    phase 1 · small molecule · completed

    1 trial →

31. VY-AADC02

    NEUROCRINE BIOSCIENCES INC

    Parkinson's Disease

    phase 1 · mab · completed

    1 trial →

32. Vagus Nerve Stimulation

    Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd

    Refractory Epilepsy

    phase 1 · other · active

    1 trial →

33. Velusetrag

    Theravance Biopharma Ireland Umited

    Alzheimer's Disease

    phase 1 · small molecule · completed

    1 trial →

34. WN45319

    Hoffmann-La Roche

    Multiple Sclerosis (MS)

    phase 1 · other · active

    1 trial →

35. [123I] IBVM and SPECT imaging

    United Therapeutics Europe Ltd

    Parkinson Disease

    phase 1 · small molecule · completed

    1 trial →

36. [18F]APN-1607

    The First People's Hospital of Lianyungang

    Alzheimer Disease

    phase 1 · small molecule · active

    1 trial →

37. anti-thymocyte globulin

    Ultragenyx UK Limited

    Multiple Sclerosis

    phase 1 · small molecule · completed

    1 trial →

38. cyclophosphamide

    Ultragenyx UK Limited

    Multiple Sclerosis

    phase 1 · small molecule · completed

    1 trial →

39. high-fat diet group（AD16 20mg）

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Alzheimer Disease

    phase 1 · other · completed

    1 trial →

40. ketamine

    Summit Therapeutics

    Multiple Sclerosis

    phase 1 · small molecule · completed

    1 trial →

41. monoclonal antibody M-T412

    Ultragenyx UK Limited

    Multiple Sclerosis

    phase 1 · small molecule · completed

    1 trial →

42. sabirnetug (ACU193)

    Acumen Pharmaceuticals

    Alzheimer Disease

    phase 1 · small molecule · completed

    1 trial →

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