Intelligence · Clinical Pipeline

Neurology & CNS · Phase I

Neurology & CNS programs at Phase I — ClinicalTrials.gov pipeline intelligence.

Programs: 142

Quick answer

Neurology & CNS Phase I programs: NovaPharmaNews indexes 142 matching clinical development programs from ClinicalTrials.gov with sponsor, modality, and NCT cross-links.

Top sponsors

Phase Ib Safety, Tolerability and Pharmacokinetic Study of Subcutaneously Administered HER-096 in Healthy Volunteer Subjects and Patients with Parkinson’s Disease

Lacuna Pharma Pty Ltd

Parkinson’s Disease

phase 1 other active

1 trial
Pimavanserin

Acadia Pharmaceuticals B.V.

Parkinson Disease

phase 1 small molecule terminated

1 trial
Placebo

Jazz Pharmaceuticals Ireland Limited

Epilepsy

phase 1 small molecule completed

1 trial
Pramipexole

United Therapeutics Europe Ltd

Parkinson Disease

phase 1 small molecule completed

1 trial
Randomised, bioequivalence clinical trial of rasagiline 1 mg capsules vs rasagiline 1 mg tablets, after a single oral dose administration to healthy volunteers under fasting conditions in crossover replicated design.

Laboratorios Tillomed Spain S.L.U

Parkinson´s disease

phase 1 other active

1 trial
Randomised, crossover bioequivalence clinical trial of donepezil 5 mg capsules vs donepezil 5 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions

Laboratorios Tillomed Spain S.L.U

Alzheimer's disease

phase 1 other active

1 trial
Randomised, crossover bioequivalence clinical trial of memantine 20 mg capsules versus memantine 20 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions.

Laboratorios Tillomed Spain S.L.U

Alzheimer’s disease

phase 1 other active

1 trial
Risperidone

The First People's Hospital of Lianyungang

Schizophrenia

phase 1 small molecule active

1 trial
Roflumilast

Takeda

Schizophrenia

phase 1 small molecule completed

1 trial
SAM-315

Wyeth is now a wholly owned subsidiary of Pfizer

Alzheimer Disease

phase 1 small molecule completed

1 trial
SER-214

Serina Therapeutics

Parkinson's Disease

phase 1 small molecule active

1 trial
SER-252 (PEOZ-apomorphine)

Serina Therapeutics

PARKINSON DISEASE (Disorder)

phase 1 small molecule active

1 trial
SPD489 (Lisdexamfetamine dimesylate)

Takeda

Schizophrenia

phase 1 small molecule completed

1 trial
SPN-804O

SUPERNUS PHARMACEUTICALS, INC.

Epilepsies, Partial

phase 1 small molecule completed

1 trial
Safety Study to Compare the Gastrointestinal Tolerability of Oral Tegomil Fumarate and Dimethyl Fumarate (Tecfidera®) in Healthy Volunteers.

NEURAXPHARM AUSTRALIA PTY LIMITED

Multiple Sclerosis

phase 1 other active

1 trial
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NBI-1117570 in Healthy Adults

NEUROCRINE BIOSCIENCES INC

Neurological and neuropsychiatric conditions

phase 1 other active

1 trial
Safety, pharmacokinetics and pharmacodynamics study of Leucettinib-21 in healthy subjects, Down Syndrom and Alzheimer patients

Lacuna Pharma Pty Ltd

A Phase 1, Randomized, Double-Blind, Placebo-Controlled, First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Ascending Doses and Food Effect of Leucettinib-21 in Healthy Male Subjects, followed by an open single dose of Leucettinib-21 in Down Syndrome individuals, and patients with Alzheimer’s disease

phase 1 other active

1 trial
Stem Cell

EuroGen Pharmaceuticals Ltd

Neurological; Disorder, Nervous System

phase 1 mab terminated

1 trial
Study of Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of NIO752 in Early Alzheimer's Disease Participants

Novartis Pharmaceuticals

Alzheimer’s Disease

phase 1 other active

1 trial
TAK-058

Takeda

Schizophrenia

phase 1 small molecule terminated

1 trial
TAK-063

Takeda

Schizophrenia

phase 1 small molecule completed

1 trial
TAK-071

Takeda

Alzheimer Disease

phase 1 small molecule terminated

1 trial
TAK-831 Oral Suspension

NEUROCRINE BIOSCIENCES INC

Schizophrenia, Cerebellar Ataxia

phase 1 small molecule terminated

1 trial
TAK-935

Takeda

Epilepsy, Molecular Mechanisms of Pharmalogical Action, Protective Agents

phase 1 small molecule completed

1 trial
TTP4000

vTv Therapeutics

Alzheimer's Disease

phase 1 small molecule completed

1 trial
The pivotal bioequivalence study comparing the test product to the reference product, which belongs to the group of medicines used in treatment of schizophrenia in adult patients.

Lacuna Pharma Pty Ltd

Not applicable (submitted trial is a BE study in healthy subjects).

phase 1 other active

1 trial
The pivotal bioequivalence study comparing the test product to the reference product, which belongs to the group of medicines used in treatment of schizophrenia in adults patients.

Lacuna Pharma Pty Ltd

Bioequivalence study under fasting conditions

phase 1 other active

1 trial
Topiramate IR

SUPERNUS PHARMACEUTICALS, INC.

Epilepsy

phase 1 small molecule completed

1 trial
UB-312

BRIGHT MINDS BIOSCIENCES INC.

Parkinson's Disease

phase 1 mab completed

1 trial
UX-GIP001

Xiyuan Hospital of China Academy of Chinese Medical Sciences

Epilepsy

phase 1 small molecule active

1 trial
VHX-896 and iloperidone

Vanda Pharmaceuticals Netherlands B.V.

Schizophrenia

phase 1 small molecule completed

1 trial
VX15/2503

VACCINEX, INC.

Multiple Sclerosis

phase 1 small molecule completed

1 trial
VY-AADC01

NEUROCRINE BIOSCIENCES INC

Parkinson's Disease

phase 1 mab completed

1 trial
VY-AADC01

NEUROCRINE BIOSCIENCES INC

Idiopathic Parkinson's Disease

phase 1 small molecule completed

1 trial
VY-AADC02

NEUROCRINE BIOSCIENCES INC

Parkinson's Disease

phase 1 mab completed

1 trial
Vagus Nerve Stimulation

Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd

Refractory Epilepsy

phase 1 other active

1 trial
Velusetrag

Theravance Biopharma Ireland Umited

Alzheimer's Disease

phase 1 small molecule completed

1 trial
[123I] IBVM and SPECT imaging

United Therapeutics Europe Ltd

Parkinson Disease

phase 1 small molecule completed

1 trial
[18F]APN-1607

The First People's Hospital of Lianyungang

Alzheimer Disease

phase 1 small molecule active

1 trial
anti-thymocyte globulin

Ultragenyx UK Limited

Multiple Sclerosis

phase 1 small molecule completed

1 trial
cyclophosphamide

Ultragenyx UK Limited

Multiple Sclerosis

phase 1 small molecule completed

1 trial
high-fat diet group（AD16 20mg）

Xiyuan Hospital of China Academy of Chinese Medical Sciences

Alzheimer Disease

phase 1 other completed

1 trial
ketamine

Summit Therapeutics

Multiple Sclerosis

phase 1 small molecule completed

1 trial
monoclonal antibody M-T412

Ultragenyx UK Limited

Multiple Sclerosis

phase 1 small molecule completed

1 trial
sabirnetug (ACU193)

Acumen Pharmaceuticals

Alzheimer Disease

phase 1 small molecule completed

1 trial
A Phase 1, Open-Label, Multiple-Part Trial to Evaluate the Drug-Drug Interaction Potential of PRAX-628 in Healthy Participants

Chongqing Precision Biotech Co., Ltd

Epilepsy

phase 1 other active

1 trial

Frequently asked questions

How many neurology & cns Phase I programs exist?

142 programs match both the therapeutic area and stage filters in our published index.

Data attribution: Data sources · All pipeline programs

Quick answer

Top sponsors

Phase Ib Safety, Tolerability and Pharmacokinetic Study of Subcutaneously Administered HER-096 in Healthy Volunteer Subjects and Patients with Parkinson’s Disease

Pimavanserin

Placebo

Pramipexole

Randomised, bioequivalence clinical trial of rasagiline 1 mg capsules vs rasagiline 1 mg tablets, after a single oral dose administration to healthy volunteers under fasting conditions in crossover replicated design.

Randomised, crossover bioequivalence clinical trial of donepezil 5 mg capsules vs donepezil 5 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions

Randomised, crossover bioequivalence clinical trial of memantine 20 mg capsules versus memantine 20 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions.

Risperidone

Roflumilast

SAM-315

SER-214

SER-252 (PEOZ-apomorphine)

SPD489 (Lisdexamfetamine dimesylate)

SPN-804O

Safety Study to Compare the Gastrointestinal Tolerability of Oral Tegomil Fumarate and Dimethyl Fumarate (Tecfidera®) in Healthy Volunteers.

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NBI-1117570 in Healthy Adults

Safety, pharmacokinetics and pharmacodynamics study of Leucettinib-21 in healthy subjects, Down Syndrom and Alzheimer patients

Stem Cell

Study of Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of NIO752 in Early Alzheimer's Disease Participants

TAK-058

TAK-063

TAK-071

TAK-831 Oral Suspension

TAK-935

TTP4000

The pivotal bioequivalence study comparing the test product to the reference product, which belongs to the group of medicines used in treatment of schizophrenia in adult patients.

The pivotal bioequivalence study comparing the test product to the reference product, which belongs to the group of medicines used in treatment of schizophrenia in adults patients.

Topiramate IR

UB-312

UX-GIP001

VHX-896 and iloperidone

VX15/2503

VY-AADC01

VY-AADC01

VY-AADC02

Vagus Nerve Stimulation

Velusetrag

[123I] IBVM and SPECT imaging

[18F]APN-1607

anti-thymocyte globulin

cyclophosphamide

high-fat diet group（AD16 20mg）

ketamine

monoclonal antibody M-T412

sabirnetug (ACU193)

​​A Phase 1, Open-Label, Multiple-Part Trial to Evaluate the Drug-Drug Interaction Potential of PRAX-628 in Healthy Participants​

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A Phase 1, Open-Label, Multiple-Part Trial to Evaluate the Drug-Drug Interaction Potential of PRAX-628 in Healthy Participants