Neurology & CNS · Phase I

Top sponsors

• Anaxis Pharma 10 programs
• Takeda 10 programs
• BRIGHT MINDS BIOSCIENCES 9 programs
• NEUROCRINE BIOSCIENCES 7 programs
• HOFFMANN-LA ROCHE 6 programs
• Chinese Academy of 5 programs
• Alnylam Netherlands 4 programs
• Denali Therapeutics 4 programs
• IONIS PHARMACEUTICALS 4 programs
• Ultragenyx UK 4 programs
• United Therapeutics Europe 4 programs
• SUPERNUS PHARMACEUTICALS 3 programs

1. GRoningen Early-PD Ambroxol Treatment Pharmacokinetics

   Disc Medicine

   Parkinson's disease

   phase 1 · other · active

   1 trial →

2. GT-02287

   Gain Therapeutics

   Parkinson Disease

   phase 1 · small molecule · active

   1 trial →

3. Glycerol Phenylbutyrate 1100 MG/ML [Ravicti]

   S.L

   STXBP1 Encephalopathy With Epilepsy, SLC6A1 Neurodevelopmental Disorder

   phase 1 · small molecule · active

   1 trial →

4. HEC122505MsOH

   Sunshine Guojian Pharmaceutical (Shanghai) Co.,

   Parkinson Disease

   phase 1 · small molecule · completed

   1 trial →

5. Human Amniotic Epithelial Stem Cells

   Xiyuan Hospital of China Academy of Chinese Medical Sciences

   Parkinson's Disease

   phase 1 · mab · completed

   1 trial →

6. ION269

   IONIS PHARMACEUTICALS INC

   Alzheimer Disease

   phase 1 · small molecule · terminated

   1 trial →

7. ION269-CS1

   IONIS PHARMACEUTICALS INC

   Alzheimer’s Disease in Individuals with Down Syndrome

   phase 1 · other · active

   1 trial →

8. IONIS MAPTRx

   IONIS PHARMACEUTICALS INC

   Mild Alzheimer's Disease

   phase 1 · small molecule · completed

   1 trial →

9. IRX4204

   IO Biotech

   Parkinson's Disease

   phase 1 · small molecule · completed

   1 trial →

10. ITI-214 Dose A

    Takeda

    Schizophrenia

    phase 1 · small molecule · terminated

    1 trial →

11. Infudopa i.v.

    Lxo Ireland Designated Activity Company

    Parkinson Disease

    phase 1 · small molecule · completed

    1 trial →

12. Ixazomib (NINLARO®) capsules / Matching placebo capsules

    Takeda

    Relapsing Remitting Multiple Sclerosis

    phase 1 · small molecule · active

    1 trial →

13. Jiedu Tongluo granules

    Xiyuan Hospital of China Academy of Chinese Medical Sciences

    Post-stroke Depression

    phase 1 · small molecule · completed

    1 trial →

14. KHK6640

    KYOWA KIRIN AUSTRALIA PTY LTD

    Alzheimer Disease

    phase 1 · small molecule · completed

    1 trial →

15. KIH24001

    The George Institute

    Alzheimer´s disease

    phase 1 · other · active

    1 trial →

16. KYV-101 (Biological) - 0.33 ×10^8 cells

    Kyverna Therapeutics

    Progressive Multiple Sclerosis

    phase 1 · mab · active

    1 trial →

17. KYV-101 anti-CD19 CAR-T cell therapy

    Kyverna Therapeutics

    Multiple Sclerosis

    phase 1 · mab · active

    1 trial →

18. Ketamine

    United Therapeutics Europe Ltd

    Acute Depression

    phase 1 · small molecule · terminated

    1 trial →

19. LAMOT-04-24

    Lacuna Pharma Pty Ltd

    Bipolar disorder, Epilepsy

    phase 1 · other · active

    1 trial →

20. LBT-3627

    Biotech Pharmaceutical Co.,

    Parkinson Disease

    phase 1 · small molecule · active

    1 trial →

21. LCAR-AIO T cells

    Nanjing Legend Biotech Co.

    Multiple Sclerosis (MS)

    phase 1 · mab · active

    1 trial →

22. LX1001

    Lexeo Therapeutics

    Alzheimer Disease

    phase 1 · mab · active

    1 trial →

23. LY03010/CT-EUR-102

    Lacuna Pharma Pty Ltd

    Schizophrenia

    phase 1 · other · active

    1 trial →

24. LY4006896

    Eli Lilly and Company

    Parkinson Disease

    phase 1 · small molecule · active

    1 trial →

25. Levodopa

    Blackmores Limited

    Parkinson's Disease

    phase 1 · small molecule · completed

    1 trial →

26. Levodopa Cyclops®

    BRIGHT MINDS BIOSCIENCES INC.

    Parkinson

    phase 1 · other · completed

    1 trial →

27. Lu AF28996

    H. Lundbeck A/S

    Parkinson Disease

    phase 1 · small molecule · active

    1 trial →

28. Lu AF28996 in Patients With Parkinson's Disease

    H. Lundbeck A/S

    Parkinson's Disease

    phase 1 · other · active

    1 trial →

29. MEDI1341

    Takeda

    Parkinson's Disease

    phase 1 · small molecule · completed

    2 trials →

30. MP-101-02

    Lacuna Pharma Pty Ltd

    Amyotrophic Lateral Sclerosis (ALS), Alzheimer’s Disease (AD)

    phase 1 · other · active

    1 trial →

31. MRx0029

    4D Molecular Therapeutics

    Idiopathic Parkinson Disease

    phase 1 · mab · terminated

    1 trial →

32. Motivational Interviewing

    BRIGHT MINDS BIOSCIENCES INC.

    Schizophrenia

    phase 1 · other · completed

    1 trial →

33. N-acetylcysteine

    Ultragenyx UK Limited

    Parkinson's Disease

    phase 1 · small molecule · completed

    1 trial →

34. NBI-1117570-1769

    NEUROCRINE BIOSCIENCES INC

    Neurological and neuropsychiatric conditions

    phase 1 · other · active

    1 trial →

35. NDX-1017

    BRIGHT MINDS BIOSCIENCES INC.

    Alzheimer Disease

    phase 1 · small molecule · completed

    1 trial →

36. NIO752B12201

    Novartis Pharmaceuticals

    Alzheimer’s Disease

    phase 1 · other · active

    1 trial →

37. NMRA-323511

    Neumora Therapeutics

    Alzheimer's Disease

    phase 1 · small molecule · completed

    1 trial →

38. NXPTEGO/23/P1-4

    NEURAXPHARM AUSTRALIA PTY LIMITED

    Multiple Sclerosis

    phase 1 · other · active

    1 trial →

39. Narcan 40 MG/ML Nasal Spray

    BRIGHT MINDS BIOSCIENCES INC.

    Opioid Induced Respiratory Depression

    phase 1 · small molecule · active

    1 trial →

40. ONC206 Powder

    AXIM BIOTECHNOLOGIES, INC.

    Diffuse Midline Glioma (DMG), and Other Recurrent Primary Malignant Central Nervous System (CNS) Tumors

    phase 1 · small molecule · active

    1 trial →

41. Obecabtagene autoleucel (obe-cel)

    Autolus GmbH

    Progressive Multiple Sclerosis

    phase 1 · mab · active

    1 trial →

42. Olanzapine Extended Release

    Teva Pharma GmbH

    Schizophrenia, Schizoaffective Disorder

    phase 1 · small molecule · completed

    1 trial →

43. Opicapone

    NEUROCRINE BIOSCIENCES INC

    Parkinson Disease

    phase 1 · small molecule · completed

    1 trial →

44. Oxcarbazepine (brand name vs generic drugs)

    BRIGHT MINDS BIOSCIENCES INC.

    Epilepsy

    phase 1 · small molecule · completed

    1 trial →

45. PIPE-307

    Contineum Therapeutics

    Multiple Sclerosis

    phase 1 · small molecule · completed

    2 trials →

46. PIPE-791

    Contineum Therapeutics

    Multiple Sclerosis

    phase 1 · small molecule · completed

    1 trial →

47. PRAX-628-102

    Chongqing Precision Biotech Co., Ltd

    Epilepsy

    phase 1 · other · active

    1 trial →

48. Pimavanserin

    Acadia Pharmaceuticals B.V.

    Parkinson Disease

    phase 1 · small molecule · terminated

    1 trial →

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