Wednesday, July 8, 2026

Patent intelligence · US

US 12378553

Modified double-stranded RNA agents

granted A61PA61P43/00
Status granted
Linked drugs 1
Pipeline programs 6
Years to expiry 19
Applicant portfolio 379
Patent details — US 12378553

Quick answer

US 12378553 (Modified double-stranded RNA agents) is held by Alnylam Pharmaceuticals, Inc.. Status: granted. Granted Aug 5, 2025. Expires Jul 31, 2045 (19 years remaining) — relevant for patent-cliff and LOE planning.

Key facts

Grant date
Expiration
Claims
43
CPC classes
A61P, A61P43/00

More from Alnylam Pharmaceuticals, Inc.

Related pharmaceutical patents in our USPTO index.

  1. US 12416006

    Cell death-inducing DFFA-like effector B (CIDEB) iRNA compositions and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Expires Sep 11, 2045

    granted
  2. US 12404508

    Ketohexokinase (KHK) iRNA compositions and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Expires Aug 28, 2045

    granted
  3. US 12397013

    Extrahepatic delivery

    Alnylam Pharmaceuticals, Inc. · Expires Aug 21, 2045

    granted
  4. US 12385043

    Modified double-stranded RNA agents

    Alnylam Pharmaceuticals, Inc. · Expires Aug 7, 2045

    granted
  5. US 12385044

    Modified double-stranded RNA agents

    Alnylam Pharmaceuticals, Inc. · Expires Aug 7, 2045

    granted
  6. US 12364762

    Biodegradable lipids for the delivery of active agents

    Alnylam Pharmaceuticals, Inc. · Expires Jul 17, 2045

    granted
  7. US 12350338

    Biodegradable lipids for the delivery of active agents

    Alnylam Pharmaceuticals, Inc. · Expires Jul 3, 2045

    granted

Frequently asked questions

What is US patent 12378553?

US 12378553 (Modified double-stranded RNA agents) is held by Alnylam Pharmaceuticals, Inc.. Status: granted. Granted Aug 5, 2025. Expires Jul 31, 2045 (19 years remaining) — relevant for patent-cliff and LOE planning.

Who owns US 12378553?

Alnylam Pharmaceuticals, Inc. is listed as the applicant in USPTO PatentsView records indexed by NovaPharmaNews. We track 379 pharmaceutical patents for this assignee.

When does US 12378553 expire?

Our index shows an expiration date of Jul 31, 2045 (19 years from today). Confirm material dates against USPTO, FDA Orange Book, or qualified counsel before contractual decisions.