Wednesday, July 8, 2026

Patent intelligence · US

US 12221610

RNAi agents for inhibiting expression of HIF-2 alpha (EPAS1), compositions thereof, and methods of use

granted A61KA61K31/7088A61PA61P35/00
Status granted
Linked drugs 2
Pipeline programs 6
Years to expiry 19
Applicant portfolio 126
Related coverage 1
Patent details — US 12221610

Quick answer

US 12221610 (RNAi agents for inhibiting expression of HIF-2 alpha (EPAS1), compositions thereof, and methods of use) is held by Arrowhead Pharmaceuticals, Inc.. Status: granted. Granted Feb 11, 2025. Expires Feb 6, 2045 (19 years remaining) — relevant for patent-cliff and LOE planning.

Key facts

Grant date
Expiration
Claims
20
CPC classes
A61K, A61K31/7088, A61P, A61P35/00

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Frequently asked questions

What is US patent 12221610?

US 12221610 (RNAi agents for inhibiting expression of HIF-2 alpha (EPAS1), compositions thereof, and methods of use) is held by Arrowhead Pharmaceuticals, Inc.. Status: granted. Granted Feb 11, 2025. Expires Feb 6, 2045 (19 years remaining) — relevant for patent-cliff and LOE planning.

Who owns US 12221610?

Arrowhead Pharmaceuticals, Inc. is listed as the applicant in USPTO PatentsView records indexed by NovaPharmaNews. We track 126 pharmaceutical patents for this assignee.

When does US 12221610 expire?

Our index shows an expiration date of Feb 6, 2045 (19 years from today). Confirm material dates against USPTO, FDA Orange Book, or qualified counsel before contractual decisions.