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Intelligence · Patents

Expiring patents (≤12 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
645

Quick answer

645 pharmaceutical patents in our index expire within the next 12 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 2006127471

    Pegylated liposomal formulations of hydrophobic photosensitizers for photodynamic therapy

    CERAMOPTEC IND INC [DE] · Granted Thu Jun 15 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jun 10 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7064141

    Method for preventing, treating or inhibiting development of simple retinopathy and preproliferative retinopathy

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 20 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7063840

    TIE-2 ligands, methods of making and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 20 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7063847

    Compositions and methods for enhancing immune responses mediated by antigen-presenting cells

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Jun 20 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7064106

    Gene and use thereof

    Takeda Chemical Industries Ltd. · Granted Tue Jun 20 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7064112

    Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist

    CAN-FITE BIOPHARMA LTD. · Granted Tue Jun 20 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7064181

    Physiologically active peptide and its use

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 20 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 15 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7067109

    Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids

    The Board of Regents of the University of Texas System · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7067318

    Methods for transfecting T cells

    United States of America as represented by the Secretary of the Air Force · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7067482

    Cross-linked glycopeptide-cephalosporin antibiotics

    Theravance, Inc. · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7067527

    Thienopyridine derivatives, their production and use

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7067620

    Antibacterial agents

    Theravance, Inc. · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7067635

    Nucleotide and deduced amino acid sequences of tumor gene Int6

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US RE39146

    Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof

    BRACCO INT BV [NL] · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7067254

    Diagnosis and treatment of inflammation and hyperactive immune conditions

    The Board of Regents of the University of Texas System · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7067122

    Modified live Edwardsiella tarda vaccine for aquatic animals

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7067256

    Ribozyme mediated inactivation of the androgen receptor

    The Board of Regents of the University of Texas System · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7067111

    Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging

    The Board of Regents of the University of Texas System · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7067317

    Regulation of angiogenesis with zinc finger proteins

    Sangamo Biosciences, Inc. · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7067481

    Cross-linked glycopeptide-cephalosporin antibiotics

    Theravance, Inc. · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7067483

    Pharmaceutical compositions containing a gycopeptide antibiotic and a cyclodextrin

    Theravance, Inc. · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7067537

    Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7067546

    Crystal and process for producing the same

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7067633

    Targeting cellular entry, cell survival, and pathogenicity by dynein light chain 1/PIN in human cells

    The Board of Regents of the University of Texas System · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7067661

    Pyrazolopyrimidines as cyclin dependent kinase inhibitors

    Pharmacopeia Drug Discovery, Inc. · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7067653

    Porphyrin Based neuton capture agents for cancer therapy

    The Regents of the University of California · Granted Tue Jun 27 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 22 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. CA 2591889

    TRAITEMENT DE LA DEPRESSION MELANCOLIQUE SEVERE A L'AIDE D'EPA

    AMARIN NEUROSCIENCE LTD [GB] · Granted Thu Jun 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jun 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7070771

    Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells

    The Regents of the University of California · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7070790

    Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7071293

    Alpha helical peptides with broad spectrum antimicrobial activity that are insensitive to salt

    The Regents of the University of California · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7070607

    Bioabsorbable polymeric implants and a method of using the same to create occlusions

    The Regents of the University of California · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7070971

    Glycosyl sulfotransferases GST-4α, GST-4β, and GST-6

    The Regents of the University of California · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7070959

    Modified chimeric polypeptides with improved pharmacokinetic properties

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7070805

    Rapidly disintegrable solid preparation

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7070957

    STARS—a muscle-specific actin-binding protein

    The Board of Regents of the University of Texas System · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7070934

    Ligand-controlled regulation of endogenous gene expression

    Sangamo Biosciences, Inc. · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7070788

    Follicle stimulating hormone superagonists

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7070956

    Peptides and derivatives thereof showing cell attachment, spreading and detachment activity

    REGENBiotech, Inc. · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7071168

    Anti-cancer compounds and methods related thereto

    The Regents of the University of Colorado · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7071200

    Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

    Neurocrine Biosciences, Inc. · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7071205

    5-cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds

    Ligand Pharmaceuticals Incorporated · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7070972

    Janus family kinases and identification of immune modulators

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7070973

    Butyrylcholinesterase variants and methods of use

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7070975

    Protein and DNA thereof

    Takeda Chemical Industries Ltd. · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7071224

    Diphenylmethyl compounds useful as muscarinic receptor antagonists

    Theravance, Inc. · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7071318

    Methods and compositions for stabilizing microtubules and intermediate filaments in striated muscle cells

    The Board of Regents of the University of Texas System · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. AU 2001289696

    New use of lipase inhibitors

    CHEPLAPHARM ARZNEIMITTEL GMBH [DE] · Granted Thu Jul 06 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jul 01 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7074410

    Modified HCV peptide vaccines

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jul 11 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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