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Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7166704

    Antibodies immunologically specific for PD2, a protein that is amplified and overexpressed in pancreatic cancer

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Jan 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7166450

    Hyaluronan synthase gene and uses thereof

    The Board of Regents of the University of Oklahoma · Granted Tue Jan 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7166584

    Cholesterol transport gene

    Xenon Genetics Inc. · Granted Tue Jan 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7166588

    Derivatives and analogs of galanthamine

    SANOCHEMIA PHARMAZEUTIKA AG · Granted Tue Jan 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7166619

    Prenylation inhibitors and methods of their synthesis and use

    PPD Discovery, Inc. · Granted Tue Jan 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7166721

    Preparation of 1H-imidazo[4,5-C] quinolin 4-amines via novel 1H-imidazo[4,5-c] quinolin 4-cyano and 1H-imidazo[4,5-c] quinolin 4-carboxamide intermediates

    TEVA Gyógyszergyár Zártkörüen Müködö Részvénytárasaság · Granted Tue Jan 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7166762

    Method of constructing heart failure model animal

    Takeda Pharmaceutical Company Limited · Granted Tue Jan 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7169411

    Composition for delivery of biological agents and methods for the preparation thereof

    UNIVERSITY OF NEBRASKA BOARD OF REGENTS · Granted Tue Jan 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7169779

    Inhibitors of p38

    Vertex Pharmaceuticals Incorporated · Granted Tue Jan 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7169384

    Tumor suppressor CAR-1

    The Board of Regents of the University of Texas System · Granted Tue Jan 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7169594

    Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jan 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7169726

    Catalyst for isomerization of solid fischer-tropsch paraffins and method for its production

    KataLeuna GmbH Catalysts · Granted Tue Jan 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7169799

    Process for producing crystal

    Takeda Pharmaceutical Company Limited · Granted Tue Jan 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7169815

    3-methoxybenzyl thiourea derivatives and improved lipid compositions containing same

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Jan 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7169798

    Inhibitors of c-Jun N terminal kinases (JNK) and other protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Jan 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7169800

    Imidazole compositions useful as inhibitors of protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Jan 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7169801

    Histone deacetylase inhibitors

    Takeda San Diego, Inc. · Granted Tue Jan 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7172869

    Methods for transfecting T cells

    United States of America as represented by the Secretary of the Air Force · Granted Tue Feb 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7173112

    Antibody to GALP and uses thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Feb 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7173039

    Protein kinase inhibitors

    Theravance, Inc. · Granted Tue Feb 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7172761

    Polyvalent immunogen

    The Regents of the University of California · Granted Tue Feb 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7172768

    Storage stable powder compositions of interleukin-4 receptor

    Nektar Therapeutics · Granted Tue Feb 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7172770

    Mesoporous compositions for use in drug delivery

    The Board of Regents of the University of Texas System · Granted Tue Feb 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7172876

    Method of screening therapeutic agents for nerve degeneration associated diseases

    Takeda Pharmaceutical Company Limited · Granted Tue Feb 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7173027

    Receptor selective cannabimimetic aminoalkylindoles

    UNIVERSITY OF CONNECTICUT · Granted Tue Feb 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7173005

    Insulin and IGF-1 receptor agonists and antagonists

    ANTYRA INC. · Granted Tue Feb 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7173007

    Therapy for microbial infections

    The United States of America as represented by the Department of Veteran Affairs · Granted Tue Feb 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7173062

    Method for the improvement of skin wrinkles using retinyl retinoate

    ENPRANI CO., LTD. · Granted Tue Feb 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7176179

    Selective induction of cell death by delivery of amino-terminal interleukin-1-α pro-piece polypeptide

    The Regents of the University of California · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7176283

    Protease-activated receptor 3 and uses thereof

    The Regents of the University of California · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7175830

    Imaging of drug accumulation as a guide to antitumor therapy

    The United States of America, as represented by the Secretary, Health and Human Services · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7175838

    Use of a promoter of T-cell expansion and an inducer of CD40 stimulation in the treatment or prevention of a pathologic state

    The United States of America represented by the Department of Health and Human Services · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7175843

    Methods for selectively stimulating proliferation of T cells

    United States of America as represented by the Secretary of the Air Force · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7175845

    Monoclonal antibodies against ricin toxin and methods of making and using thereof

    The United States of America as represented by the Secretary of the Army · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7175848

    Ricin A chain mutants lacking enzymatic activity as vaccines to protect against aerosolized ricin

    The Board of Regents of the University of Texas System · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7175981

    Method of diagnosing stage or aggressiveness of breast and prostate cancer based on levels of fatty acid binding proteins

    The United States of America as represented by the Secretary of the Army · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7175990

    Method of determining endometrial receptivity

    The Regents of the University of California · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7176208

    Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors

    Enanta Pharmaceuticals, Inc. · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7176010

    Isolated human protein having esterase activity and DNA encoding the same

    Takeda Pharmaceutical Company Limited · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7176019

    RICK3 nucleic acids and proteins

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7176201

    Modulation of anxiety through blockade of anandamide hydrolysis

    The Regents of the University of California · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7176211

    Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

    Neurocrine Biosciences, Inc. · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7176244

    Use of 2-nitropropanol, 2-nitroethane, and 2-nitroethanol for control of microbial pathogens

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7176232

    Salinosporamides and methods for use thereof

    The Regents of the University of California · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7176302

    Liposomal phosphodiester, phosphorothioate, and p-ethoxy oligonucleotides

    The Board of Regents of the University of Texas System · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7176233

    Salinosporamides and methods for use thereof

    The Regents of the University of California · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7176280

    Isolated polypeptides and compositions from the venom of P. transvaalicus and methods of use

    The Regents of the University of California · Granted Tue Feb 13 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 08 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7179217

    Apparatus for enhancing tissue repair in mammals

    The United States of America as represented by the Administrator of the National Aeronautics and Space Administration · Granted Tue Feb 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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