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Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7153838

    Pharmacologically acceptable solvent vehicles

    The Board of Regents of the University of Texas System · Granted Tue Dec 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7153972

    Benzimidazole derivatives, their production and use

    Takeda Pharmaceutical Company Limited · Granted Tue Dec 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7153677

    Hyaluronan synthase gene and uses thereof

    The Board of Regents of the University of Oklahoma · Granted Tue Dec 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7153519

    Implantable substrate coated with a macromer having free radical polymerizable substituents

    The Board of Regents of the University of Texas System · Granted Tue Dec 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7153509

    Immunogenic peptides comprising a T-helper epitope and a B-cell neutralizing antibody epitope

    The Regents of the University of California · Granted Tue Dec 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7153514

    Use of botulinum toxin therapy for prostatic hyperplasia and related disorders

    The Regents of the University of Colorado · Granted Tue Dec 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7153683

    TAO protein kinase polypeptides and methods of use therefor

    The Board of Regents of the University of Texas System · Granted Tue Dec 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7153936

    Semaphorin gene family

    The Regents of the University of California · Granted Tue Dec 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7153880

    Substituted diphenyl heterocycles useful for treating HCV infection

    Rigel Pharmaceuticals, Inc. · Granted Tue Dec 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7153866

    Use of tempol for the treatment of Li-Fraumeni syndrome and ataxia telangiectasia

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Dec 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7153882

    Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Dec 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7153947

    Ixodes salivary anticomplement protein

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Dec 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7153967

    Preparation of 1H-imidazo [4,5-C] quinolin-4-amines via 1H-imidazo [4,5-C] quinolin-4-phthalimide intermediates

    TEVA Gyógyszergyár Zártkörüen Müködö Részvénytárasaság · Granted Tue Dec 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7157476

    Aminofurazan compounds useful as protein kinase inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Jan 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7157082

    Cardioprotective therapies based on enzymatic elimination of lipid peroxides by allene oxide synthase

    THE ARIZONA BOARD OF REGENTS · Granted Tue Jan 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7157259

    Murine lecithin-cholesterol acyltransferase protein

    Takeda Pharmaceutical Company Limited · Granted Tue Jan 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7157092

    Acyl pseudodipeptides, preparation method and pharmaceutical compositions containing same

    OM PHARMA · Granted Tue Jan 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7157435

    Methods for modulation of the effects of aging on the primate brain

    The Regents of the University of California · Granted Tue Jan 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7157439

    HoxD3, HoxA3, and HoxB3 compositions and methods for improved wound healing

    The Regents of the University of California · Granted Tue Jan 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7157473

    Pyridyl substituted heterocycles useful for treating or preventing HCV infection

    Rigel Pharmaceuticals, Inc. · Granted Tue Jan 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7157495

    Hexahydrofuro[2,3-B]furan-3-YL-N-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl}carbamate as retroviral protease inhibitor

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jan 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7157546

    Water-soluble polymer alkanals

    Nektar Therapeutics AL, Corporation · Granted Tue Jan 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7157554

    Glycopeptide carboxy-saccharide derivatives

    Theravance, Inc. · Granted Tue Jan 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7157584

    Benzimidazole derivative and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Jan 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7160867

    Rapamycin carbohydrate derivatives

    Isotechnika, Inc. · Granted Tue Jan 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7160984

    Process for preparing glycopeptide derivatives

    Theravance, Inc. · Granted Tue Jan 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7160726

    Compositions comprising conditioned cell culture media and uses thereof

    SkinMedica, Inc. · Granted Tue Jan 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7160375

    Aqueous glittering color material composition

    SAKURA COLOR PRODUCTS CORPORATION · Granted Tue Jan 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7160868

    Nr-CAM gene, nucleic acids and nucleic acid products for therapeutic and diagnostic uses for tumors

    Northwest Hospital · Granted Tue Jan 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7160720

    CHAMP—a novel cardiac helicase-like factor

    The Board of Regents of the University of Texas System · Granted Tue Jan 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7160887

    Aromatic amine derivatives, their production and use

    Takeda Pharmaceutical Company Limited · Granted Tue Jan 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7160722

    Master bone formation transcription factor: compositions and methods of use

    The Board of Regents of the University of Texas System · Granted Tue Jan 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7161003

    Pyrazolopyrimidines as cyclin dependent kinase inhibitors

    Pharmacopeia Drug Discovery, Inc. · Granted Tue Jan 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7161012

    Processes for preparing amorphous atorvastatin hemi-calcium

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Jan 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7161059

    Human hookworm model and method for maintaining human hookworm in a non-human primate

    The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland · Granted Tue Jan 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7163818

    Bacteriophage having multiple host range

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jan 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7163678

    Reovirus for the treatment of ral-mediated cellular proliferative disorders

    ONCOLYTICS BIOTECH INC. · Granted Tue Jan 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7163925

    p16 expression constructs and their application in cancer therapy

    The Board of Regents of the University of Texas System · Granted Tue Jan 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7163700

    Amorphous drug beads

    Capricorn Pharma Inc. · Granted Tue Jan 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7163673

    Sunscreen reagents from hydroxy-substituted acylglycerides

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Jan 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7163686

    Protein A based binding domains with desirable activities

    The Regents of the University of California · Granted Tue Jan 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7163806

    Somatic cells with ablated PrP gene and methods of use

    The Regents of the University of California · Granted Tue Jan 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7163824

    Regulation of endogenous gene expression in cells using zinc finger proteins

    Sangamo Biosciences, Inc. · Granted Tue Jan 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7163935

    Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jan 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7163934

    Methods for treating delirium glucocorticoid receptor-specific antagonists

    Corcept Therapeutics Incorporated · Granted Tue Jan 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7163946

    5-substituted 7,9-difluoro-5H-chromeno[3,4-f]quinoline compounds as selective progesterone receptor modulator compounds

    Ligand Pharmaceuticals Incorporated · Granted Tue Jan 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7164000

    RANTES mutants and therapeutic applications thereof

    FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR · Granted Tue Jan 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7166578

    Orally administered peptides synergize statin activity

    The Regents of the University of California · Granted Tue Jan 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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