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Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7138533

    Preventives/remedies for urinary disturbance

    Takeda Pharmaceutical Company Limited · Granted Tue Nov 21 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 16 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7138569

    Nucleic acids encoding pseudomonas hop proteins and use thereof

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Nov 21 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 16 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7141234

    Imaging of drug accumulation as a guide to antitumor therapy

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Nov 28 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 23 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7141598

    Imidazole derivatives, production method thereof and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Nov 28 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 23 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7141671

    Biphenyl derivatives

    Theravance, Inc. · Granted Tue Nov 28 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 23 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7141233

    Radionuclide labeling of vitamin B12 and coenzymes thereof

    Regents of the University of Minnesota · Granted Tue Nov 28 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 23 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7141236

    Methods and compositions for delivering macromolecules to or via the respiratory tract

    Nektar Therapeutics · Granted Tue Nov 28 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 23 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7141238

    Compositions for reducing UV-induced inhibition of collagen biosynthesis in human skin

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Nov 28 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 23 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7141434

    Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing an adenosine kinase

    Rigel Pharmaceuticals, Inc. · Granted Tue Nov 28 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 23 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7141409

    Hyaluronan synthase gene and uses thereof

    The Board of Regents of the University of Oklahoma · Granted Tue Nov 28 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 23 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7141405

    Chimeric GB virus B (GBV-B)

    The Board of Regents of the University of Texas System · Granted Tue Nov 28 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 23 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7141553

    A3AR agonists for the treatment of inflammatory arthritis

    Can-Fite Biopharma Ltd. Israel · Granted Tue Nov 28 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 23 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7141589

    Methods of inhibiting formation of vascular channels and methods of inhibiting proliferation

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Nov 28 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 23 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7141648

    Synthesis of cyclosporin analogs

    Isotechnika, Inc. · Granted Tue Nov 28 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 23 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7141603

    Antitumor agents

    The Regents of the University of California · Granted Tue Nov 28 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 23 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7141661

    Non-steroidal anti-inflammatory drug activated gene with anti-tumorigenic properties

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Nov 28 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 23 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7144982

    Polypeptides with therapeutic activity and methods of use

    Regents of the University of Minnesota · Granted Tue Dec 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7144575

    Methods for selectively stimulating proliferation of T cells

    United States of America as represented by the Secretary of the Air Force · Granted Tue Dec 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7144918

    Biologically active macrolides, compositions, and uses thereof

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Dec 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7144720

    Protein and DNA thereof

    Takeda Chemical Industries Ltd. · Granted Tue Dec 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7144875

    Methods of treating fungal infections using lupeol

    Regents of the University of Minnesota · Granted Tue Dec 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7144880

    Compositions relating to novel compounds and targets thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Dec 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7144723

    Marine actinomycete taxon for drug and fermentation product discovery

    The Regents of the University of California · Granted Tue Dec 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7144862

    Orally administered peptides to ameliorate atherosclerosis

    The Regents of the University of California · Granted Tue Dec 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7144867

    Anticancer glycoside compounds

    Northwestern University · Granted Tue Dec 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7144916

    Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Dec 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7144900

    Pharmaceutical composition

    Takeda Pharmaceutical Company Limited · Granted Tue Dec 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7144986

    Polypeptides comprising IL-6 ligand binding receptor domains

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Dec 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 30 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7148196

    Anticancer compounds and methods

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Dec 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7148197

    Orally administered small peptides synergize statin activity

    The Regents of the University of California · Granted Tue Dec 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7147863

    UVA (> 360-400) and UVB (300-325) specific sunscreens

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Dec 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7148036

    DNA molecules encoding cartilage-derived morphogenetic proteins

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Dec 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7148193

    Compounds that bind to growth hormone receptor

    ANTYRA INC. · Granted Tue Dec 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7147806

    Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein

    Aphios Corporation · Granted Tue Dec 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7148251

    Amino ceramide-like compounds and therapeutic methods of use

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Dec 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7148201

    Use of human plasma hyaluronidase in cancer treatment

    The Regents of the University of California · Granted Tue Dec 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7148323

    Major neutralization site of hepatitis E virus and use of this neutralization site in methods of vaccination and in methods of screening for neutralizing antibodies to hepatitis E virus

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Dec 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7148376

    Polymorphic forms of nateglinide

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Dec 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7150869

    Modified cytokines for use in cancer therapy

    FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR · Granted Tue Dec 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7151101

    Inhibitors of p38

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7150766

    Method of particle formation

    Nektar Therapeutics UK, Ltd · Granted Tue Dec 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7151087

    CC chemokine receptor 5 DNA, new animal models and therapeutic agents for HIV infection

    The United States of America as represented by the Department of Health and Human Resources · Granted Tue Dec 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7150984

    Attenuated human rotavirus vaccine

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Dec 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7150871

    Treatment of acute lung injury, fibrosis and metastasis with antagonists of αvβ6

    The Regents of the University of California · Granted Tue Dec 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7150875

    Recombinant Plasmodium vivax merozoite protein-1 p42 vaccine

    The United States of America as represented by the Secretary of the Army · Granted Tue Dec 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7151100

    Indole compounds useful for the treatment of cancer

    The Regents of the University of California · Granted Tue Dec 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7151115

    Diphenylmethyl compounds useful as muscarinic receptor antagonists

    Theravance, Inc. · Granted Tue Dec 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7151183

    Processes for preparing amorphous atorvastatin hemi-calcium

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Dec 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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