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Expiring patents (≤12 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
629

Quick answer

629 pharmaceutical patents in our index expire within the next 12 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7122200

    Vitro engineered, regenerated urinary tract tissue compositions and methods for producing same

    The Board of Regents of the University of Oklahoma · Granted Tue Oct 17 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 12 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7122214

    Drynaria extractions for treating osteoporosis and their extraction process

    Xiyuan Hospital Affiliated to China Academy of TCM. · Granted Tue Oct 17 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 12 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7122552

    Inhibitors of JAK and CDK2 protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Oct 17 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 12 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7122572

    Calixpyrroles

    The Board of Regents of the University of Texas System · Granted Tue Oct 17 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 12 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7122624

    Parathyroid hormone receptor ligands

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Oct 17 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 12 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7122681

    Desolvation process for the production of atorvastatin hemi-calcium essentially free of bound organic solvent

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Oct 17 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 12 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7122714

    Mouse models of human prostate cancer

    The Regents of the University of California · Granted Tue Oct 17 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 12 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7125866

    Therapeutic applications of pro-apoptotic benzodiazepines

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Oct 24 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 19 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7125845

    Aza-peptide macrocyclic hepatitis C serine protease inhibitors

    Enanta Pharmaceuticals, Inc. · Granted Tue Oct 24 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 19 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7125541

    Combined methods for tumor vasculature targeting and tumor treatment with radiotherapy

    THE UNIVERSTY OF TEXAS SYSTEM,BOARD OF REGENTS · Granted Tue Oct 24 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 19 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7125553

    Methods of inducing immune tolerance using immunotoxins

    The United States of America as represented by the Department of Health and Human Services c/o Centers for Disease Control and Prevention · Granted Tue Oct 24 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 19 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7125857

    Modulators of DNA cytosine-5 methyltransferase and methods for use thereof

    The Regents of the University of California · Granted Tue Oct 24 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 19 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7125969

    ETS-related gene overexpressed in human breast and epithelial cancers

    The Regents of the University of California · Granted Tue Oct 24 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 19 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7126008

    Carvedilol

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Oct 24 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 19 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7125892

    Aryl aniline β2 adrenergic receptor agonists

    Theravance, Inc. · Granted Tue Oct 24 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 19 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7125965

    MRI probes of membrane potential

    The Regents of the University of California · Granted Tue Oct 24 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 19 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7128895

    Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability

    The Regents of the University of California · Granted Tue Oct 31 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 26 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7128894

    Contrast enhancing solution for use in confocal microscopy

    United States Department of Energy · Granted Tue Oct 31 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 26 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7129342

    Infectious cDNA clone of GB virus B and uses thereof

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Oct 31 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 26 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7128904

    Material containing metal ion ligand complex producing nitric oxide in contact with blood

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Oct 31 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 26 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7129221

    6,11-bicyclic erythromycin derivatives

    Enanta Pharmaceuticals, Inc. · Granted Tue Oct 31 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 26 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7129039

    Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof

    The Board of Regents of the University of Texas System · Granted Tue Oct 31 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 26 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7129052

    Peptides and their utility in modulation of behavior of cells expressing α3β1 integrins

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Oct 31 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 26 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7129332

    Anti-EGFRvIII scFvs with improved cytotoxicity and yield, immunotoxins based thereon, and methods of use thereof

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Oct 31 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 26 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7129358

    Processes for the production of substituted 2-(2-pyridylmethyl) sulfinyl-1H-benzimidazoles

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Oct 31 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 26 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7132271

    Methods for enhancing the production of viral vaccines in cell culture

    The Regents of the University of California · Granted Tue Nov 07 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 02 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7132420

    Aspartic protease inhibitors

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Nov 07 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 02 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7132109

    Using heat shock proteins to increase immune response

    University of Connecticut Health Center · Granted Tue Nov 07 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 02 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7132392

    Inhibition of cell motility and angiogenesis by inhibitors of Grb2-SH2-domain

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Nov 07 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 02 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7132102

    Bacteriocins and novel bacterial strains

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Nov 07 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 02 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7132403

    Antihelminthic anthraquinones and method of use thereof

    The Regents of the University of California · Granted Tue Nov 07 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 02 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7132122

    Direct micro-patterning of lipid bilayers using UV light and selected uses thereof

    The Regents of the University of California · Granted Tue Nov 07 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 02 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7132422

    Sodium channel modulators

    Theravance, Inc. · Granted Tue Nov 07 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 02 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7132454

    HEXIM1 as a suppressor of HIV replication and cardiac hypertrophy

    The Regents of the University of California · Granted Tue Nov 07 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 02 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7132547

    Preventives/remedies for urinary disturbance

    Takeda Pharmaceutical Company Limited · Granted Tue Nov 07 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 02 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7135453

    Reagents and methods for smooth muscle therapies

    THE ARIZONA BOARD OF REGENTS · Granted Tue Nov 14 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 09 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7135177

    Immunoliposomes that optimize internalization into target cells

    The Regents of the University of California · Granted Tue Nov 14 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 09 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7135490

    Method for the treatment of glomerulonephritis

    Takeda Pharmaceutical Company Limited · Granted Tue Nov 14 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 09 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7135176

    VMP-like sequences of pathogenic Borrelia

    The Board of Regents of the University of Texas System · Granted Tue Nov 14 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 09 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7135192

    Cationic lipid compositions targeting angiogenic endothelial cells

    The Regents of the University of California · Granted Tue Nov 14 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 09 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7135324

    Viral recombinases, related articles, and methods of use thereof

    UNIVERSITY OF CONNECTICUT · Granted Tue Nov 14 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 09 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7135303

    Regulators of type-1 tumor necrosis factor receptor and other cytokine receptor shedding

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Nov 14 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 09 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7135611

    Compositions and methods for characterizing and regulating Wnt pathways

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Nov 14 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 09 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7138237

    Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen

    The Regents of the University of California · Granted Tue Nov 21 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 16 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7138137

    Stable pharmaceutical formulation of paroxetine hydrochloride and a process for preparation thereof

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Nov 21 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 16 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7138141

    Dispersible macromolecule compositions and methods for their preparation and use

    Nektar Therapeutics · Granted Tue Nov 21 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 16 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7138249

    Screening method

    Takeda Pharmaceutical Company Limited · Granted Tue Nov 21 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 16 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7138384

    Modulators of DNA cytosine-5 methyltransferase and methods for use thereof

    The Regents of the University of California · Granted Tue Nov 21 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 16 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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