🇺🇸 FDA

Intelligence · Patents

Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7109011

    Hyaluronan synthase gene and uses thereof

    The Board of Regents of the University of Oklahoma · Granted Tue Sep 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7108981

    Specific binding agents for KSHV vIL-6 that neutralize a biological activity

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Sep 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7109179

    Methods and compositions comprising DNA damaging agents and p53

    The Board of Regents of the University of Texas System · Granted Tue Sep 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7109200

    Carbamate derivatives, process for producing the same and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Sep 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7109188

    Methods and compositions for treating atheroma, tumors and other neoplastic tissue

    The Board of Regents of the University of Texas System · Granted Tue Sep 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7109245

    Vasoconstrictor cannabinoid analogs

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Sep 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7109215

    Compounds possessing neuronal activity

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7109380

    Cyclopentenedione antifungal compounds and methods for their use

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Sep 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7112317

    Combined methods and compositions for tumor vasculature targeting and tumor treatment

    The Board of Regents of the University of Texas System · Granted Tue Sep 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7112341

    Pulmonary administration of dry powder formulations for treating infertility

    Nektar Therapeutics · Granted Tue Sep 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7112338

    Cationic liposome delivery of taxanes to angiogenic blood vessels

    The Regents of the University of California · Granted Tue Sep 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7112332

    Oral or intranasal vaccines using hydrophobic complexes having proteosomes and lipopolysaccharides

    The United States of America as represented by the Secretary of the Army · Granted Tue Sep 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7112442

    Peptides for gene delivery

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Sep 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7112342

    Enriched platelet wound healant

    Cytomedix, Inc. · Granted Tue Sep 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7112574

    C2,8-disubstituted adenosine derivatives and their different uses

    CAN-FITE BIOPHARMA LTD. · Granted Tue Sep 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7112415

    Method of preparing cell cultures from biological specimens for assaying a response to an agent

    Precision Therapeutics, Inc. · Granted Tue Sep 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7112566

    Systemic administration of Hypocretin-1

    The Regents of the University of California · Granted Tue Sep 26 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 21 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7115262

    Chimeric protein for prevention and treatment of HIV infection

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Oct 03 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7115637

    Inhibitors of p38

    Vertex Pharmaceuticals Incorporated · Granted Tue Oct 03 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7115260

    Interleukin-1β converting enzyme like apoptotic protease-6

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Oct 03 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7115280

    Particle formation methods and their products

    Nektar Therapeutics UK, Ltd · Granted Tue Oct 03 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7115405

    Hyaluronan synthase gene and uses thereof

    The Board of Regents of the University of Oklahoma · Granted Tue Oct 03 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7115577

    Colorectal neoplasia prophylaxis

    The Board of Regents of the University of Texas System · Granted Tue Oct 03 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7115360

    Isolation and use of solid tumor stem cells

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Oct 03 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7115560

    Methods for modulating gastric secretion using prokineticin receptor antagonists

    The Regents of the University of California · Granted Tue Oct 03 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7115582

    HoxD3 and HoxA3 compositions and methods for improved wound healing

    The Regents of the University of California · Granted Tue Oct 03 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7115590

    Phosphoramidate, and mono-, di-, and tri-phosphate esters of (1R, cis)-4-(6-amino-9H-purin-9-yl)-2-cyclopentene-1-methanol as antiviral agents

    University College Cardiff Consultants Limited · Granted Tue Oct 03 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7115746

    Processes for the facile synthesis of diaryl amines and analogues thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Oct 03 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7115728

    Human peroxisome proliferator activated receptor γ

    Ligand Pharmaceuticals Incorporated · Granted Tue Oct 03 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7115739

    Triazole compounds useful as protein kinase inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Oct 03 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 28 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7119064

    Use of colostrinin, constituent peptides thereof, and analogs thereof as modulators of intracellular signaling molecules

    The Board of Regents of the University of Texas System · Granted Tue Oct 10 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7118738

    Recombinant pox virus for immunization against MUC1 tumor-associated antigen

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Oct 10 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7118752

    Compositions and methods for inhibiting the proliferation and invasiveness of malignant cells comprising E-domain peptides of IGF-I

    UNIVERSITY OF CONNECTICUT · Granted Tue Oct 10 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7118919

    13C glucose breath test for the diagnosis of diabetic indications and monitoring glycemic control

    Isotechnika, Inc. · Granted Tue Oct 10 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7119223

    Interleukin-1 and tumor necrosis factor-α modulators, synthesis of said modulators and their enantiomers and methods of using said modulators

    The Regents of the University of California · Granted Tue Oct 10 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7118746

    Conditioned cell culture medium compositions and methods of use

    SkinMedica, Inc. · Granted Tue Oct 10 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7118747

    AT4 receptor ligands as angiogenic, anti-angiogenic, and anti-tumor agents

    Pacific Northwest Biotechnology Inc. · Granted Tue Oct 10 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7118873

    Polynucleotides encoding cellular transporters and methods of use thereof

    UNIVERSITY OF CONNECTICUT · Granted Tue Oct 10 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7118758

    Transformed bacteria producing CS6 antigens as vaccines

    The United States of America as represented by the Secretary of the Army · Granted Tue Oct 10 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7118865

    Methods for diagnosing severe systemic lupus erythematosus

    Regents of the University of Minnesota · Granted Tue Oct 10 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7119103

    β3-Adrenoreceptor agonists, agonist compositions and methods of using

    Molecular Design International, Inc. · Granted Tue Oct 10 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7119200

    Pyrazolopyrimidines as cyclin dependent kinase inhibitors

    Pharmacopeia Drug Discovery, Inc. · Granted Tue Oct 10 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7119066

    Modified ciliary neurotrophic factor (CNTF)

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Oct 10 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7119105

    Methods for treating neurodegenerative disorders using aspartyl protease inhibitors

    The Regents of the University of California · Granted Tue Oct 10 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7119221

    Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses

    Esperion Therapeutics, Inc. · Granted Tue Oct 10 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 05 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7122579

    Eye treatments using synthetic thyroid hormone compositions

    The Regents of the University of California · Granted Tue Oct 17 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 12 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7122558

    Quinuclidine derivatives and medicinal compositions containing the same

    Almirall Prodesfarma S.A. · Granted Tue Oct 17 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 12 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7122542

    Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds

    Rigel Pharmaceuticals, Inc. · Granted Tue Oct 17 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 12 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.