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Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7097841

    Ferritin fusion proteins for use in vaccines and other applications

    New Century Pharmaceuticals, Inc. · Granted Tue Aug 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7097856

    Dendrimeric support or carrier macromolecule

    The Regents of the University of California · Granted Tue Aug 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7097972

    Method and composition for regulating apoptosis

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Aug 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7097991

    Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof

    The Regents of the University of California · Granted Tue Aug 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7097998

    Aβ42 lowering agents

    The Regents of the University of California · Granted Tue Aug 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7098025

    Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor

    Ligand Pharmaceuticals Incorporated · Granted Tue Aug 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7098191

    Hyperthermic inducible expression vectors for gene therapy and methods of use thereof

    THE ARIZONA BOARD OF REGENTS · Granted Tue Aug 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7098197

    Phosphonate compounds

    The Regents of the University of California · Granted Tue Aug 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7098306

    Method and compositions for treating hepatocellular cancer

    The Regents of the University of California · Granted Tue Aug 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7098345

    Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-YL)methyl]-4H-carbazol-4-one

    TEVA Gyógyszergyár Zártkörüen Müködö Részvénytárasaság · Granted Tue Aug 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7098364

    Phenylethanolamine compounds as β2-receptor agonists, and methods of use and preparation thereof

    Jinzhou Jiutai Pharmaceutical Co., Ltd., China · Granted Tue Aug 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7098330

    Pyrazolylamine substituted quinazoline compounds useful as protein kinase inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Aug 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7101541

    Utilization of non-viral sequences for minus-strand DNA transfer and gene reconstitution

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Sep 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 31 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7101852

    Composition and method for treatment and prevention of restenosis

    The Board of Regents of the University of Texas System · Granted Tue Sep 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 31 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7101863

    Pharmaceutical compositions with wound healing or anti-complementary activity comprising a dextran derivative

    BIODEX · Granted Tue Sep 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 31 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7101547

    Method for the prevention and treatment of diseases caused by an inflammatory response mediated by endogenous substance P by using anti-substance P antibodies

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Sep 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 31 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7101548

    Functional role of adrenomedullin (AM) and the gene-related product (PAMP) in human pathology and physiology

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Sep 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 31 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7101846

    Methods and compositions for optimization of oxygen transport by cell-free systems

    The Regents of the University of California · Granted Tue Sep 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 31 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7101557

    Combined tissue factor methods for coagulation and tumor treatment

    The Board of Regents of the University of Texas System · Granted Tue Sep 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 31 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7101899

    5-pyridyl-1,3-azole compounds, process for producing the same and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Sep 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 31 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7101909

    Calcium channel drugs and uses

    Theravance, Inc. · Granted Tue Sep 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 31 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7101932

    Method for the preparation of 1-benzotriazolyl carbonate esters of poly (ethylene glycol)

    Nektar Therapeutics AL, Corporation · Granted Tue Sep 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 31 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7102059

    DNA molecules and polypeptides of Pseudomonas syringae Hrp pathogenicity island and their uses

    The Board of Regents University Community College System of Nevada on Behalf of the University of Nevada-Las Vegas · Granted Tue Sep 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 31 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7101867

    Benzofuran derivatives, their production and use

    Takeda Pharmaceutical Company Limited · Granted Tue Sep 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 31 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7101964

    Intermediate for preparing glycopeptide derivatives

    Theravance, Inc. · Granted Tue Sep 05 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 31 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7105156

    Method of using an adenoviral vector encoding a retinoblastoma protein to treat hyperproliferating cells

    The Regents of the University of California · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7105183

    Chlorite in the treatment of neurodegenerative disease

    The Regents of the University of California · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7105546

    Acyclic and cyclic amine derivatives

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7105641

    MCP-1 receptor antibodies

    The Regents of the University of California · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7105169

    Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7105330

    Human plasma hyaluronidase

    The Regents of the University of California · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7105170

    Latent human tuberculosis model, diagnostic antigens, and methods of use

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7105171

    Porin B (PorB) as a therapeutic target for prevention and treatment of infection by Chlamydia

    The Regents of the University of California · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7105488

    G protein-coupled receptor antagonists

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7105496

    Methods and compositions for inhibiting angiogenesis

    Northwestern University · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7105514

    Substituted indolealkanoic acids

    The Institute for Dibetes Discovery LLC · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7105558

    Gastrin and cholecystokinin receptor lignads (iv)

    The James Black Foundation Limited · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7105560

    Use of etodolac in the treatment of multiple myeloma

    The Regents of the University of California · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7105561

    Use of etodolac for the treatment of prostate cancer

    The Regents of the University of California · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7105572

    Stable emulsion compositions

    Takeda Pharmaceutical Company Limited · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7105643

    Monoclonal antibodies specific for crack cocaine metabolites, a cell line producing the same, and crack cocaine conjugates

    The United States of America as represented by the Attorney General of the Dept. of Justice · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7105695

    Synthesis of combretastatin A-2 prodrugs

    ARIZONA BOARD OF REGENTS, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Sep 12 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7109172

    Inhibitors of serine proteases, particularly HCV NS3-NS4A protease

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7109210

    Quinuclidine derivatives and medicinal compositions containing the same

    Almirall Prodesfarma S.A. · Granted Tue Sep 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7109303

    Modified cytokines for use in cancer therapy

    FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR · Granted Tue Sep 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7109323

    Formulation of boronic acid compounds

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Sep 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7108975

    Atlastin

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Sep 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7108981

    Specific binding agents for KSHV vIL-6 that neutralize a biological activity

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Sep 19 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 14 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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