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Expiring patents (≤12 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
629

Quick answer

629 pharmaceutical patents in our index expire within the next 12 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7084132

    Artemisinins with improved stability and bioavailability for therapeutic drug development and application

    The United States of America as represented by the Secretary of the Army · Granted Tue Aug 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 27 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7084127

    C2,5′-disubstituted and N6, C2,5′-trisubstituted adenosine derivatives and their different uses

    CAN-FITE BIOPHARMA LTD. · Granted Tue Aug 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 27 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7084149

    Naphthalene derivatives, their production and use

    Takeda Pharmaceutical Company Limited · Granted Tue Aug 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 27 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7084151

    5-(1',1'-cycloalkyl/alkenyl)methylidene 1,2-dihydro-5H-chromeno[3,4-ƒ]quinolines as selective progesterone receptor modulator compounds

    Ligand Pharmaceuticals Incorporated · Granted Tue Aug 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 27 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7084154

    2-(aminomethyl) arylamide analgesics

    Pharmacopeia Drug Discovery, Inc. · Granted Tue Aug 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 27 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7084208

    N-halamine vinyl compounds and their polymeric biocides

    The Regents of the University of California · Granted Tue Aug 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 27 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7084239

    Cancer peptides of NY-ESO-1/CAG-3

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Aug 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 27 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7084266

    Cloned genome of infectious hepatitus C virus of genotype 2A and uses thereof

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Aug 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 27 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7084271

    Pyrazolopyrimidines as cyclin dependent kinase inhibitors

    Pharmacopeia Drug Discovery, Inc. · Granted Tue Aug 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 27 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7087411

    Fusion protein capable of binding VEGF

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7087392

    Antiproliferative SgK reagents and methods

    The Regents of the University of California · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7087582

    Combination for site-specifically transforming cells in vivo comprising a double-balloon catheter and nucleic acid comprising a gene encoding P21

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7087642

    Inhibitors of IMPDH enzyme

    Vertex Pharmaceuticals Incorporated · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7087633

    Method for treating perinatal asphyxia in a human or animal neonate

    Universitair Medisch Centrum · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7087095

    Hair coloring composition and method

    HairMarker LLC · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7087234

    Recombinant multivalent viral vaccine

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7086862

    Tooth bleaching process

    DISCUS DENTAL, LLC · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7087413

    Hyaluronan synthase gene and uses thereof

    The Board of Regents of the University of Oklahoma · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7087589

    Methanocarba cycloakyl nucleoside analogues

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7087591

    21-substituted progesterone derivatives as new antiprogestational agents

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7087593

    Benzimidazolidinone derivatives as muscarinic agents

    ACADIA Pharmaceuticals Inc. · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7087597

    Pyrimidine 5-carboxamide compounds, process for producing the same and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7087603

    Pyrazole compounds useful as protein kinase inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7087648

    Methods for modulating macrophage proliferation using polyamine analogs

    The Regents of the University of California · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7087715

    Human paris-1 antigen and nucleic acids: diagnostic and therapeutic uses

    Northwest Biotherapeutics, Inc. · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7087723

    Albumin-free factor VIII formulations

    UNIVERSITY OF CONNECTICUT · Granted Tue Aug 08 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7090852

    Venezuelan equine encephalitis virus replicon encoding marburg virus proteins

    The United States of America as represented by the Secretary of the Army · Granted Tue Aug 15 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 10 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7091247

    Biphenyl compound

    Takeda Pharmaceutical Company Limited · Granted Tue Aug 15 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 10 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7091343

    Compositions useful as inhibitors of protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Aug 15 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 10 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7090864

    Non-invasive gene targeting to ocular cells

    The Regents of the University of California · Granted Tue Aug 15 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 10 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7090869

    Method for producing preparation containing bioactive substance

    Takeda Pharmaceutical Company Limited · Granted Tue Aug 15 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 10 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7094413

    Combined therapy for treatment of HIV infection

    The Regents of the University of California · Granted Tue Aug 22 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7094598

    Development of a preventive vaccine for filovirus infection in primates

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Aug 22 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7094045

    Microencapsulation system and method

    The United States of America as represented by the Administrator of the National Aeronautics and Space Administration · Granted Tue Aug 22 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7094405

    Peptides which elicit a high neutralizing antibody titer, cytotoxic T lymphocyte response and T helper cell response in a broad range of MHC type recipients

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Aug 22 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7094404

    Method for treating malignancy and autoimmune disorders in humans using tac antibodies

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Aug 22 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7094408

    Immunogenicity using a combination of DNA and vaccinia virus vector vaccines

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Aug 22 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7094411

    Avirulent, immunogenic flavivirus chimeras

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Aug 22 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7094406

    Enterically transmitted non-A/non-B hepatitis viral agent and characteristic epitopes thereof

    The United States of America as represented by the Secretary of the Department of Health and Human Services and Genelabs Technologies, Inc. · Granted Tue Aug 22 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7094424

    Cationic lipid compositions targeting angiogenic endothelial cells

    The Regents of the University of California · Granted Tue Aug 22 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7094597

    Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis

    The Regents of the University of California · Granted Tue Aug 22 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7094758

    Apoptotic compounds

    The Board of Regents of the University of Texas System · Granted Tue Aug 22 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7094772

    Phosphonate compounds

    The Regents of the University of California · Granted Tue Aug 22 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7094873

    Polypeptide that interacts with heat shock proteins

    The Board of Regents of the University of Texas System · Granted Tue Aug 22 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7094883

    Monoclonal antibody which agglutinates E. coli having the CS4-CFA/I family protein

    The United States of America as represented by the Secretary of the Army · Granted Tue Aug 22 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7097965

    Targeting antigens to the MHC class I processing pathway with an anthrax toxin fusion protein

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Aug 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7098216

    Thiazolopyrimidines useful as TNFα inhibitors

    The Regents of the University of California · Granted Tue Aug 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7097841

    Ferritin fusion proteins for use in vaccines and other applications

    New Century Pharmaceuticals, Inc. · Granted Tue Aug 29 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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