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Intelligence · Patents

Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,253

Quick answer

1,253 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7371571

    Recombinant mycobacteria overexpressing D-alanine ligase gene and uses therefore

    BOARD OF REGENTS UNIVERSITY OF NEBRASKA-LINCOLN · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7371575

    Process for ex vivo formation of mammalian bone and uses thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7371772

    Bicyclic compound, production and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7371719

    Self-assembly of peptide-amphiphile nanofibers under physiological conditions

    Northwestern University · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7375092

    Lunasin peptides

    The Regents of the University of California · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7374936

    Method and means for site directed therapy

    Actinium Phamaceuticals, Inc. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7375074

    Body weight gain inhibitor

    Takeda Chemical Industries Ltd. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7375079

    Previns as specific inhibitors and therapeutic agents for botulinum toxin B and tetanus neurotoxins

    The United States of America as represented by the Secretary of the Army · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7374931

    Vaccine against staphylococcus intoxication

    The United States of America as represented by the Secretary of the Army · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7374757

    Modified chimeric polypeptides with improved pharmacokinetic properties

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7375181

    Process for purifying glycopeptide phosphonate derivatives

    Theravance, Inc. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7375228

    Histone deacetylase inhibitors

    Takeda San Diego, Inc. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7374752

    Reovirus for the treatment of cellular proliferative disorders

    ONCOLYTICS BIOTECH INC. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7375185

    Cardiac myosin light chain kinase polypeptide, encoding nucleic acid, and methods of use

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7374754

    Use of placental alkaline phosphatase to promote skin cell proliferation

    Essential Skincare, LLC · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7375114

    Quinolinone-carboxamide compounds as 5-HT4 receptor agonists

    Theravance, Inc. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7374756

    Specific binding agents for KSHV vIL-6 that neutralize a biological activity

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7374872

    CC chemokine receptor 5 DNA, new animal models and therapeutic agents for HIV infection

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7374910

    DNA encoding galanin receptor activating peptide

    Takeda Pharmaceutical Company Limited · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7374776

    Bone-filling composition for stimulating bone-forming and bone-consolidation comprising calcium sulfate and viscous biopolymers

    REGENBiotech, Inc. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7374758

    Modified chimeric polypeptides with improved pharmacokinetic properties and methods of using thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7374770

    Topical composition for follicular delivery of an ornithine decarboxylase inhibitor

    SkinMedica, Inc. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7374932

    Human kinases and polynucleotides encoding the same, and uses thereof

    LEXICON PHARMACEUTICALS, INC. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7375086

    Modulators of Nod2 signaling

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7378277

    Methods and compositions for transforming dendritic cells and activating T cells

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7378097

    Use of penetration enhancers and barrier disruption methods to enhance the immune response of antigen and adjuvant

    The United States of America as represented by the Secretary of the Army · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7378422

    Inhibitors of serine proteases, particularly HCV NS3-NS4A protease

    Vertex Pharmaceuticals Incorporated · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7378553

    Isolated atomoxetine impurity, processes for the preparation of atomoxetine impurities and their use as reference standards

    Teva Pharmaceutical Fine Chemicals S.R.L. · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7378093

    Broadly cross-reactive neutralizing antibodies against Human Immunodeficiency Virus selected by Env-CD4-co-receptor complexes

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7378552

    Monoamine re-uptake inhibitors and methods relating thereto

    Neurocrine Biosciences, Inc. · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7378095

    Methods of treating type I diabetes by blocking VEGF-mediated activity

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7378251

    Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a thioredoxin-like 32 kDa protein

    Rigel Pharmaceuticals, Inc. · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7378273

    Expression vectors

    Gala Design, Inc. · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7378108

    Percutaneous absorption preparation of compound having angiotensin II antagonistic activity

    Takeda Pharmaceutical Company Limited · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7378257

    Bacterial superantigen vaccines

    The United States of America as represented by the Secretary of the Army · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7378386

    Anti-viral treatment methods using phosphatidylethanolamine-binding peptide derivatives

    The Board of Regents of the University of Texas System · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7378276

    Method of inducing memory B cell development and terminal differentiation

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7378496

    hKCa3/KCNN3 small conductance calcium activated potassium channel: a diagnostic marker and therapeutic target

    The Regents of the University of California · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7378403

    Akt inhibitors, pharmaceutical compositions, and uses thereof

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7378469

    Method for the preparation of 1-benzotriazolyl carbonate esters of poly(ethylene glycol)

    Nektar Therapeutics AL, Corporation · Granted Tue May 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7381748

    Compounds and related methods for inhibition of gamma-aminobutyric acid aminotransferase

    Northwestern University · Granted Tue Jun 03 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7381825

    Histone deacetylase inhibitors

    Takeda San Diego, Inc. · Granted Tue Jun 03 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7381404

    Treatment for dry macular degeneration

    The Regents of the University of California · Granted Tue Jun 03 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7381744

    Method of treating osteoporosis comprising vacuolar-type (H+)-ATPase-inhibiting compounds

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jun 03 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7381405

    Methods of preparing lymphocytes that express interleukin-2 and their use in the treatment of cancer

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jun 03 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7381699

    Reagents and methods for smooth muscle therapies

    THE ARIZONA BOARD OF REGENTS · Granted Tue Jun 03 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7381408

    Methods for chemically synthesizing immunoglobulin chimeric proteins

    Syntonix Pharmaceuticals, Inc. · Granted Tue Jun 03 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7381827

    Processes and intermediates

    Vertex Pharmaceuticals Incorporated · Granted Tue Jun 03 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 29 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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