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Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7368435

    Topical endoparasiticide and ectoparasiticide formulations

    Summit VetPharm, LLC · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7368106

    Use of a promoter of T-cell expansion and an inducer of CD40 stimulation in the treatment or prevention of a pathologic state

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7368116

    Method of enhancing a targeted immune response against tumors

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7368452

    Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors

    Enanta Pharmaceuticals, Inc. · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7368100

    Backbone-substituted bifunctional DOTA ligands, complexes and compositions thereof, and methods of using same

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7368102

    Pulmonary delivery of aminoglycosides

    Nektar Therapeutics · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7368110

    Antibodies, including Fv molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7368114

    Fusion protein including of CD4

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7368232

    High-throughput assay for virus entry and drug screening

    The Board of Regents of the University of Texas System · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7368257

    Modulators of lymphocyte activation, Mkk3b compositions and methods of use

    Rigel Pharmaceuticals, Inc. · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7368275

    In vivo incorporation of unnatural amino acids

    The Regents of the University of California · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7368279

    Three dimensional bioengineered smooth muscle tissue and sphincters and methods therefor

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7368463

    Substituted 4-amino-1-benzylpiperidine compounds

    Theravance, Inc. · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7368468

    Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7368578

    Five-membered heterocyclic compounds

    Takeda Pharmaceutical Company Limited · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7368606

    Amorphous cinacalcet hydrochloride and preparation thereof

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7368534

    Myostatin and mimetics thereof

    ORICO LIMITED · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7371372

    Compositions comprising IMPDH inhibitors and uses thereof for treating HCV infection

    Vertex Pharmaceuticals Incorporated · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7371403

    Wound dressing and method for controlling severe, life-threatening bleeding

    Providence Health System—Oregon · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7371571

    Recombinant mycobacteria overexpressing D-alanine ligase gene and uses therefore

    BOARD OF REGENTS UNIVERSITY OF NEBRASKA-LINCOLN · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7371575

    Process for ex vivo formation of mammalian bone and uses thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7371719

    Self-assembly of peptide-amphiphile nanofibers under physiological conditions

    Northwestern University · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7371772

    Bicyclic compound, production and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7371841

    Methods of modulating cold sensory perception

    The Regents of the University of California · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7371572

    Mouse titers after two immunizations with VLPs alone

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7371821

    Cloning and expression of the full length 110 kDa antigen of Orientia tsutsugamushi to be used as a vaccine component against scrub typhus

    United States of America as represented by the Secretary of the Air Force · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7371364

    Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy

    The Board of Regents of the University of Texas System · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7371385

    Method of treating immune pathologies with low dose estrogen

    Government of the United states of America dba The Department of Veterans Affairs · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7371225

    Method for convection enhanced delivery of therapeutic agents

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7371392

    Cd40 ligand adjuvant for respiratory syncytial virus

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7375228

    Histone deacetylase inhibitors

    Takeda San Diego, Inc. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7374754

    Use of placental alkaline phosphatase to promote skin cell proliferation

    Essential Skincare, LLC · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7374752

    Reovirus for the treatment of cellular proliferative disorders

    ONCOLYTICS BIOTECH INC. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7374756

    Specific binding agents for KSHV vIL-6 that neutralize a biological activity

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7374776

    Bone-filling composition for stimulating bone-forming and bone-consolidation comprising calcium sulfate and viscous biopolymers

    REGENBiotech, Inc. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7374872

    CC chemokine receptor 5 DNA, new animal models and therapeutic agents for HIV infection

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7374910

    DNA encoding galanin receptor activating peptide

    Takeda Pharmaceutical Company Limited · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7374758

    Modified chimeric polypeptides with improved pharmacokinetic properties and methods of using thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7374770

    Topical composition for follicular delivery of an ornithine decarboxylase inhibitor

    SkinMedica, Inc. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7374932

    Human kinases and polynucleotides encoding the same, and uses thereof

    LEXICON PHARMACEUTICALS, INC. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7375086

    Modulators of Nod2 signaling

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7375092

    Lunasin peptides

    The Regents of the University of California · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7374936

    Method and means for site directed therapy

    Actinium Phamaceuticals, Inc. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7375074

    Body weight gain inhibitor

    Takeda Chemical Industries Ltd. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7375079

    Previns as specific inhibitors and therapeutic agents for botulinum toxin B and tetanus neurotoxins

    The United States of America as represented by the Secretary of the Army · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7375114

    Quinolinone-carboxamide compounds as 5-HT4 receptor agonists

    Theravance, Inc. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7375185

    Cardiac myosin light chain kinase polypeptide, encoding nucleic acid, and methods of use

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7374757

    Modified chimeric polypeptides with improved pharmacokinetic properties

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 20 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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