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Intelligence · Patents

Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,253

Quick answer

1,253 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7361752

    RNAi modulation of MLL-AF4 and uses thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue Apr 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7361680

    Indole compounds useful for the treatment of cancer

    The Regents of the University of California · Granted Tue Apr 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7361756

    Method of making 7-(4-bromobutoxy)-3,4-dihydrocarbostyril

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Apr 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7361665

    Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7361332

    Treating tumors using implants comprising combinations of allogeneic cells

    The Regents of the University of California · Granted Tue Apr 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7361355

    Mutant forms of cholera holotoxin as an adjuvant

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Apr 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7361476

    Methionyl tRNA synthetase polynucleotides

    Replidyne, Inc. · Granted Tue Apr 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7361504

    Culturing Anaplasma

    Regents of the University of Minnesota · Granted Tue Apr 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7361664

    Vitamin D receptor antagonists and related compositions and methods of use

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Apr 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7361356

    Self-assembling recombinant papillomavirus capsid proteins

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Apr 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. EP 1913959

    Radioaktive Metallkomplexe enthaltend eine Tridentat-Komplex-Sequenz

    CIS BIO INT [FR] · Granted Wed Apr 23 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Apr 18 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7365165

    IL-1 antagonist formulations

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7364726

    Pharmaceutical composition for cancer treatment containing cells that express a membrane cytokine

    The Regents of the University of California · Granted Tue Apr 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7364719

    Vasoregulating compounds and methods of their use

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Apr 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7365096

    Methods for selectively inhibiting Janus tyrosine kinase 3 (Jak3)

    The Board of Regents of the University of Texas System · Granted Tue Apr 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7365047

    Use of pentagastrin to inhibit gastric acid secretion or as a diuretic

    The Regents of the University of California · Granted Tue Apr 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7365050

    Methods for modulating a drug-related effect or behavior

    The Regents of the University of California · Granted Tue Apr 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7365072

    Inhibitors of p38

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7365092

    Inhibitors of serine proteases, particularly HCV NS3-NS4A protease

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7365171

    Chemokine-like factors (CKLFs) with chemotactic and hematopoietic stimulating activities

    Beijing Medical University United Biological Engineering Company · Granted Tue Apr 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7365175

    Wit 3.0, a novel gene to control soft tissue wound healing

    The Regents of the University of California · Granted Tue Apr 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7368435

    Topical endoparasiticide and ectoparasiticide formulations

    Summit VetPharm, LLC · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7368110

    Antibodies, including Fv molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7368114

    Fusion protein including of CD4

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7368275

    In vivo incorporation of unnatural amino acids

    The Regents of the University of California · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7368452

    Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors

    Enanta Pharmaceuticals, Inc. · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7368116

    Method of enhancing a targeted immune response against tumors

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7368102

    Pulmonary delivery of aminoglycosides

    Nektar Therapeutics · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7368106

    Use of a promoter of T-cell expansion and an inducer of CD40 stimulation in the treatment or prevention of a pathologic state

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7368534

    Myostatin and mimetics thereof

    ORICO LIMITED · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7368606

    Amorphous cinacalcet hydrochloride and preparation thereof

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7368578

    Five-membered heterocyclic compounds

    Takeda Pharmaceutical Company Limited · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7368468

    Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7368463

    Substituted 4-amino-1-benzylpiperidine compounds

    Theravance, Inc. · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7368279

    Three dimensional bioengineered smooth muscle tissue and sphincters and methods therefor

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7368257

    Modulators of lymphocyte activation, Mkk3b compositions and methods of use

    Rigel Pharmaceuticals, Inc. · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7368100

    Backbone-substituted bifunctional DOTA ligands, complexes and compositions thereof, and methods of using same

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7368232

    High-throughput assay for virus entry and drug screening

    The Board of Regents of the University of Texas System · Granted Tue May 06 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 01 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 2008107607

    TARGETING VECTOR-PHOSPHOLIPID CONJUGATES

    BRACCO INT BV [NL] · Granted Thu May 08 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed May 03 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7371841

    Methods of modulating cold sensory perception

    The Regents of the University of California · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7371821

    Cloning and expression of the full length 110 kDa antigen of Orientia tsutsugamushi to be used as a vaccine component against scrub typhus

    United States of America as represented by the Secretary of the Air Force · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7371364

    Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy

    The Board of Regents of the University of Texas System · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7371392

    Cd40 ligand adjuvant for respiratory syncytial virus

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7371225

    Method for convection enhanced delivery of therapeutic agents

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7371572

    Mouse titers after two immunizations with VLPs alone

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7371385

    Method of treating immune pathologies with low dose estrogen

    Government of the United states of America dba The Department of Veterans Affairs · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7371372

    Compositions comprising IMPDH inhibitors and uses thereof for treating HCV infection

    Vertex Pharmaceuticals Incorporated · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7371403

    Wound dressing and method for controlling severe, life-threatening bleeding

    Providence Health System—Oregon · Granted Tue May 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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