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Intelligence · Patents

Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,253

Quick answer

1,253 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7339064

    Benzimidazole compound crystal

    Takeda Pharmaceutical Company Limited · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7342105

    Antibody and use thereof

    Takeda Chemical Industries Ltd. · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7342101

    Compositions and methods comprising a protective antigen of Coccidiodes immitis

    THE UNIVERSTY OF TEXAS SYSTEM,BOARD OF REGENTS · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7341709

    Compositions for labeling β-amyloid plaques and neurofibrillary tangles

    The Regents of the University of California · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7341993

    Cross-linked glycopeptide—cephalosporin antibiotics

    Theravance, Inc. · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7341871

    Nucleotide sequences for gene regulation and methods of use thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7341726

    Modified HCV peptide immunogens

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7342120

    Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7342046

    Gossypol co-crystals and the use thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 2008063603

    ULTRASOUND CONTRAST AGENTS AND METHODS OF MAKING AND USING THEM

    BRACCO INT BV [NL] · Granted Thu Mar 13 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 08 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7344712

    Urinary tract tissue graft compositions and methods for producing same

    The Board of Regents of the University of Oklahoma · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7344531

    Thermal surgical procedures and compositions

    Regents of the University of Minnesota · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7344530

    Thermal surgical procedures and compositions

    Regents of the University of Minnesota · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7345054

    Heterocyclic inhibitors of ERK2 and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7345060

    Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity

    Theravance, Inc. · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7345030

    Use of n-acetyl-d-aminoglycosamine in treatment of organ lesions related to toxicosis of drugs or chemicals

    Third Military Medical University, Chinese People's Liberation Army, P.R. of China · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7344722

    Cold-adapted influenza virus

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7344829

    Methods for detecting the efficacy of anticancer treatments

    The Board of Regents of the University of Texas System · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7345175

    Biphenyl derivatives

    Theravance, Inc. · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7346387

    Methods for improved selectivity in photo-activation and detection of molecular diagnostic agents

    Provectus Devicetech, Inc. · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7344724

    UspA1 and UspA2 antigens of Moraxella catarrhalis

    The Board of Regents of the University of Texas System · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7344703

    Mycobacterial sulfation pathway proteins and methods of use thereof

    The Regents of the University of California · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7344711

    Use of adenoviruses mutated in the VA genes for cancer treatment

    ONCOLYTICS BIOTECH INC. · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7348319

    Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Mar 25 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 20 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7348359

    Retinoid X receptor modulators

    Ligand Pharmaceuticals Incorporated · Granted Tue Mar 25 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 20 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7348429

    Process for purifying N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide(zaleplon) and crystalline forms of zaleplon accessible with the process

    TEVA Gyógyszergyár Zártkörüen Müködö Részvénytárasaság · Granted Tue Mar 25 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 20 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7348314

    Compositions and methods for inhibiting viral replication

    Alnylam Europe AG · Granted Tue Mar 25 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 20 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7348330

    1-azabicyclo [2,2,2] octan-3-one derivatives

    APREA AB · Granted Tue Mar 25 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 20 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7347987

    Inhibition of reactive oxygen species and protection of mammalian cells

    The Regents of the University of Oklahoma · Granted Tue Mar 25 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 20 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7348324

    Cyclic amine compounds as CCR5 antagonists

    Takeda Pharmaceutical Company Limited · Granted Tue Mar 25 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 20 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7348335

    Compositions useful as inhibitors of JAK and other protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Mar 25 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 20 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7348004

    Immunoglobulin chimeric monomer-dimer hybrids

    Syntonix Pharmaceuticals, Inc. · Granted Tue Mar 25 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 20 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7348153

    Method for identifying and designing immunogenic peptides

    The Board of Regents of the University of Texas System · Granted Tue Mar 25 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 20 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 2008076803

    MICROBICIDAL PREPARATIONS BASED ON 1,2-BENZISOTHIAZOLIN-3-ONEMICROBICIDAL PREPARATIONS BASED ON 1,2-BENZISOTHIAZOLIN-3-ONE

    AIR LIQUIDE SANTE INT [FR] · Granted Thu Mar 27 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Mar 22 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7351704

    Indazole-carboxamide compounds as 5-HT4 receptor agonists

    Theravance, Inc. · Granted Tue Apr 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 27 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7351830

    Pancratistatin cyclic phosphate prodrugs and phenpanstatin cyclic phosphate prodrugs

    ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Apr 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 27 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7351702

    Caspase inhibitors and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 27 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7351435

    Deglycosylated ricin toxin a-chain vaccine

    The United States of America as represented by the Secretary of the Army · Granted Tue Apr 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 27 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7351707

    Spiroazacyclic compounds as monoamine receptor modulators

    ACADIA Pharmaceuticals Inc. · Granted Tue Apr 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 27 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7351403

    Sunscreen reagents from unsaturated waxes and triglycerides

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Apr 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 27 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7351408

    Glycoconjugates and methods

    The Regents of the University of California · Granted Tue Apr 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 27 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7351411

    Methods of treating anemia by inhibition of vascular endothelial growth factor (VEGF)

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 27 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7351691

    Glycopeptide phosphonate derivatives

    Theravance, Inc. · Granted Tue Apr 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 27 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7351791

    Intermediate for preparing glycopeptide derivatives

    Theravance, Inc. · Granted Tue Apr 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 27 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7351542

    Methods of modulating tubulin deacetylase activity

    The Regents of the University of California · Granted Tue Apr 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 27 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7351717

    Substituted pyrrolidine and related compounds

    Theravance, Inc. · Granted Tue Apr 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 27 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7351718

    Substituted pyrrolidine and related compounds

    Theravance, Inc. · Granted Tue Apr 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 27 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7351739

    Bioactive compounds and methods of uses thereof

    Regents of the University of Minnesota · Granted Tue Apr 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 27 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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