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Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7332172

    Transformed bacteria producing CS6 antigens as vaccines

    The United States of America as represented by the Secretary of the Army · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7332224

    Cleaning article containing hydrophilic polymers

    ReGenesis Group · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7332471

    Cross-linked glycopeptide-cephalosporin antibiotics

    Theravance, Inc. · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7332585

    Bispecific single chain Fv antibody molecules and methods of use thereof

    The Regents of the California University · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7332590

    Molecular characteristics of non-small cell lung cancer

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7332527

    Cross-linked ionic core micelles

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7335383

    Generation of nitric oxide in vivo from nitrite, nitrate or nitrosothiols endogenous in blood

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7335477

    Truncated recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi strains Karp, Kato and Gilliam and its use in antibody based detection assays and vaccines

    United States of America as represented by the Secretary of the Air Force · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7335499

    tRNA synthetase

    Replidyne, Inc. · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7335646

    Compositions and methods for regulated protein expression in gut

    ENGENE, INC. · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7335679

    Wortmannin analogs and methods of using same

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7335658

    Pyridazine derivatives and their use as therapeutic agents

    Xenon Pharmaceuticals Inc. · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7335662

    Substituted tricyclic compounds as protein kinase inhibitors

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7335681

    Amino ceramide-like compounds and therapeutic methods of use

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7335689

    Dihydroxyl compounds and compositions for cholesterol management and related uses

    Esperion Therapeutics, Inc. · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7335685

    Crystals of ladostigil tartrate, methods of production and pharmaceutical compositions thereof

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7335773

    Intermediates for imidazonaphthyridines

    Graceway Pharmaceuticals. LLC · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7335749

    Tumor suppressor gene, p47Ing3

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7335772

    1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates

    TEVA Gyógyszergyár Zártkörüen Müködö Részvénytárasaság · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7335799

    Hydroxyl compounds and compositions for cholesterol management and related uses

    Esperion Therapeutics, Inc. · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7335744

    Prostate cancer specific internalizing human antibodies

    The Regents of the California University · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7335640

    Administration of hypocretin-1 for treatment of narcolepsy

    The Regents of the University of California · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7335356

    Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein

    The United States of America as represented by the Secretary of the Army · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7335382

    Compositions and methods for the treatment and prevention of cancer

    Northwestern University · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7338758

    Compositions and methods for the identification, assessment, prevention and therapy of human cancers

    The Board of Regents of the University of Texas System · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7339064

    Benzimidazole compound crystal

    Takeda Pharmaceutical Company Limited · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7339037

    Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7339023

    Partial peptide mimetics and methods

    Regents of the University of Minnesota · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7338652

    Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents

    Provectus Pharmatech, Inc. · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7338798

    System and method for forming a cardiac muscle construct

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7338807

    Screening assays for compounds that cause apoptosis

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7338961

    Sphingosine kinase inhibitors

    Apogee Biotechnology Corporation · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7341993

    Cross-linked glycopeptide—cephalosporin antibiotics

    Theravance, Inc. · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7341871

    Nucleotide sequences for gene regulation and methods of use thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7342046

    Gossypol co-crystals and the use thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7341726

    Modified HCV peptide immunogens

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7341709

    Compositions for labeling β-amyloid plaques and neurofibrillary tangles

    The Regents of the University of California · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7342120

    Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7342101

    Compositions and methods comprising a protective antigen of Coccidiodes immitis

    THE UNIVERSTY OF TEXAS SYSTEM,BOARD OF REGENTS · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7342105

    Antibody and use thereof

    Takeda Chemical Industries Ltd. · Granted Tue Mar 11 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 06 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7344712

    Urinary tract tissue graft compositions and methods for producing same

    The Board of Regents of the University of Oklahoma · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7344703

    Mycobacterial sulfation pathway proteins and methods of use thereof

    The Regents of the University of California · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7345060

    Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity

    Theravance, Inc. · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7344531

    Thermal surgical procedures and compositions

    Regents of the University of Minnesota · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7344530

    Thermal surgical procedures and compositions

    Regents of the University of Minnesota · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7345054

    Heterocyclic inhibitors of ERK2 and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7344711

    Use of adenoviruses mutated in the VA genes for cancer treatment

    ONCOLYTICS BIOTECH INC. · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7344724

    UspA1 and UspA2 antigens of Moraxella catarrhalis

    The Board of Regents of the University of Texas System · Granted Tue Mar 18 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 13 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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