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Intelligence · Patents

Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,253

Quick answer

1,253 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7330748

    Method for determining in vivo concentration of a metabolite

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7329775

    Compounds and related methods for mutant p53 reactivation

    Northwestern University · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. AU 2007283667

    Genes and proteins of Brachyspira hyodysenteriae and uses thereof

    SPIROGENE PTY LTD [DE] · Granted Thu Feb 14 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Feb 09 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7331920

    Glycopeptide antibiotics, combinational libraries of glycopeptide antibiotics and methods of producing same

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7332159

    Method and composition for inhibiting reperfusion injury in the brain

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7332224

    Cleaning article containing hydrophilic polymers

    ReGenesis Group · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7332471

    Cross-linked glycopeptide-cephalosporin antibiotics

    Theravance, Inc. · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7332645

    IL-21 as a regulator of immunoglobin production

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7332602

    Pyridyl substituted heterocycles useful for treating or preventing HCV infection

    Rigel Pharmaceuticals, Inc. · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7332612

    Amorphous and crystalline forms of losartan potassium and process for their preparation

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7332590

    Molecular characteristics of non-small cell lung cancer

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7332585

    Bispecific single chain Fv antibody molecules and methods of use thereof

    The Regents of the California University · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7332170

    Classical swine fever virus virulence determinant and a novel classical swine fever vaccine

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7332484

    2,4-pyrimidinediamine compounds and their uses

    Rigel Pharmaceuticals, Inc. · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7332472

    Cyclosporine analogue mixtures and their use as immunomodulating agents

    Isotechnika, Inc. · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7332470

    Methods and compositions for treating ocular disease

    The Regents of the University of California · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7332321

    Viral fibers

    The Board of Regents of the University of Texas System · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7332298

    Nucleic acids encoding multimeric proteins of TNF superfamily ligands

    The Regents of the University of California · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7332287

    Methods and compositions for diagnosing breast cancer

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7332281

    Therapeutic targets in cancer

    Sagres Discovery, Inc. · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7332469

    Intrapleural single-chain urokinase alone or complexed to its soluble receptor protects against pleural adhesions

    The Board of Regents of the University of Texas System · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7332172

    Transformed bacteria producing CS6 antigens as vaccines

    The United States of America as represented by the Secretary of the Army · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7332527

    Cross-linked ionic core micelles

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7335356

    Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein

    The United States of America as represented by the Secretary of the Army · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7335685

    Crystals of ladostigil tartrate, methods of production and pharmaceutical compositions thereof

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7335749

    Tumor suppressor gene, p47Ing3

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7335772

    1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates

    TEVA Gyógyszergyár Zártkörüen Müködö Részvénytárasaság · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7335773

    Intermediates for imidazonaphthyridines

    Graceway Pharmaceuticals. LLC · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7335744

    Prostate cancer specific internalizing human antibodies

    The Regents of the California University · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7335640

    Administration of hypocretin-1 for treatment of narcolepsy

    The Regents of the University of California · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7335689

    Dihydroxyl compounds and compositions for cholesterol management and related uses

    Esperion Therapeutics, Inc. · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7335799

    Hydroxyl compounds and compositions for cholesterol management and related uses

    Esperion Therapeutics, Inc. · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7335383

    Generation of nitric oxide in vivo from nitrite, nitrate or nitrosothiols endogenous in blood

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7335382

    Compositions and methods for the treatment and prevention of cancer

    Northwestern University · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7335477

    Truncated recombinant major outer membrane protein antigen (r56) of Orientia tsutsugamushi strains Karp, Kato and Gilliam and its use in antibody based detection assays and vaccines

    United States of America as represented by the Secretary of the Air Force · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7335499

    tRNA synthetase

    Replidyne, Inc. · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7335646

    Compositions and methods for regulated protein expression in gut

    ENGENE, INC. · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7335679

    Wortmannin analogs and methods of using same

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7335658

    Pyridazine derivatives and their use as therapeutic agents

    Xenon Pharmaceuticals Inc. · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7335662

    Substituted tricyclic compounds as protein kinase inhibitors

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7335681

    Amino ceramide-like compounds and therapeutic methods of use

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 26 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 21 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7338807

    Screening assays for compounds that cause apoptosis

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7339037

    Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7338961

    Sphingosine kinase inhibitors

    Apogee Biotechnology Corporation · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7339023

    Partial peptide mimetics and methods

    Regents of the University of Minnesota · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7338652

    Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents

    Provectus Pharmatech, Inc. · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7338798

    System and method for forming a cardiac muscle construct

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7338758

    Compositions and methods for the identification, assessment, prevention and therapy of human cancers

    The Board of Regents of the University of Texas System · Granted Tue Mar 04 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 28 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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