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Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7323297

    Stabilized polynucleotide complexes and methods

    The Regents of the University of California · Granted Tue Jan 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7323166

    Lactic acid bacteria cultures that inhibit food-borne pathogens

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Jan 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7323171

    Methods of treating skin conditions using inhibitors of the CD2/LFA-3 interaction

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jan 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7323173

    Methods for treating breast cancer using a mammary cell growth inhibitor

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jan 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7323334

    Screening and therapeutic methods relating to neurogenesis

    The Regents of the University of California · Granted Tue Jan 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7323340

    Compositions and methods for regulating bacterial pathogenesis

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Jan 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7323459

    Crystal forms, methods for their preparation and method for preparation of olanzapine

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Jan 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7323616

    Genetically altered mice deficient in functional caspase-9

    Vertex Pharmaceuticals Incorporated · Granted Tue Jan 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7326695

    Anti-bacterial agents based upon oxoanion binding

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Feb 05 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7326691

    Compositions comprising amphotericin B, methods, and systems

    Nektar Therapeutics · Granted Tue Feb 05 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7326542

    Compositions and methods for regulating bacterial pathogenesis

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Feb 05 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7326570

    Induction of tubular morphogenesis using pleiotrophin

    The Regents of the University of California · Granted Tue Feb 05 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7326790

    Diphenylisoxazole compounds and hydro isomers thereof

    Rigel Pharmaceuticals, Inc. · Granted Tue Feb 05 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7326697

    Methods for increasing the therapeutic response to electroconvulsive therapy

    Corcept Therapeutics Incorporated · Granted Tue Feb 05 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7326712

    Substituted tricyclic compounds as protein kinase inhibitors

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Feb 05 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7326713

    Substituted tricyclic compound as protein kinase inhibitors

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Feb 05 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7326734

    Treatment of bladder and urinary tract cancers

    The Regents of the University of California · Granted Tue Feb 05 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 31 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7329652

    Diaminotriazole compounds useful as protein kinase inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7329681

    Inhibitors of IMPDH enzyme

    Vertex Pharmaceuticals Incorporated · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7329759

    Illudin analogs useful as antitumor agents

    The Regents of the University of California · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7329401

    Cyclooxygenase-2 selective agents useful as imaging probes and related methods

    The Regents of the University of California · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7329642

    β-2-glycoprotein is an inhibitor of angiogenesis

    The Board of Regents of the University of Texas System · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7329651

    Cannabimimetic ligands

    UNIVERSITY OF CONNECTICUT · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7329502

    ZAP-70 expression as a marker for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7329752

    Carbamate compounds as 5-HT4 receptor agonists

    Theravance, Inc. · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7329511

    Nucleic acid encoding GAD65

    The Regents of the University of California · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7329638

    Drug delivery compositions

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7329669

    Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

    Neurocrine Biosciences, Inc. · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7329671

    2,4-pyrimidinediamine compounds and their uses

    Rigel Pharmaceuticals, Inc. · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7329672

    2,4-pyrimidinediamine compounds and their uses

    Rigel Pharmaceuticals, Inc. · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7329721

    Maleamic acid polymer derivatives and their bioconjugates

    Nektar Therapeutics AL, Corporation · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7329680

    Heterocycle substituted carboxylic acids

    The Institute for Pharmaceutical Discovery, LLC · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7330748

    Method for determining in vivo concentration of a metabolite

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7329775

    Compounds and related methods for mutant p53 reactivation

    Northwestern University · Granted Tue Feb 12 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 07 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7332224

    Cleaning article containing hydrophilic polymers

    ReGenesis Group · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7332471

    Cross-linked glycopeptide-cephalosporin antibiotics

    Theravance, Inc. · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7332159

    Method and composition for inhibiting reperfusion injury in the brain

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7331920

    Glycopeptide antibiotics, combinational libraries of glycopeptide antibiotics and methods of producing same

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7332170

    Classical swine fever virus virulence determinant and a novel classical swine fever vaccine

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7332172

    Transformed bacteria producing CS6 antigens as vaccines

    The United States of America as represented by the Secretary of the Army · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7332469

    Intrapleural single-chain urokinase alone or complexed to its soluble receptor protects against pleural adhesions

    The Board of Regents of the University of Texas System · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7332281

    Therapeutic targets in cancer

    Sagres Discovery, Inc. · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7332287

    Methods and compositions for diagnosing breast cancer

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7332298

    Nucleic acids encoding multimeric proteins of TNF superfamily ligands

    The Regents of the University of California · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7332321

    Viral fibers

    The Board of Regents of the University of Texas System · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7332470

    Methods and compositions for treating ocular disease

    The Regents of the University of California · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7332472

    Cyclosporine analogue mixtures and their use as immunomodulating agents

    Isotechnika, Inc. · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7332484

    2,4-pyrimidinediamine compounds and their uses

    Rigel Pharmaceuticals, Inc. · Granted Tue Feb 19 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Feb 14 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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