🇺🇸 FDA

Intelligence · Patents

Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7309792

    Dimeric small molecule potentiators of apoptosis

    The Board of Regents of the University of Texas System · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7311921

    Multi-subtype FIV vaccines

    The Regents of the University of California · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7312301

    Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof

    Nektar Therapeutics AL, Corporation · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7311911

    Methods for inhibiting angiogenesis

    The Regents of the University of California · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7311916

    Methods of eliciting broadly neutralizing antibodies targeting HIV-1 gp41

    The Government of the United States of American, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7312198

    Protein compositions for promoting wound healing and skin regeneration

    Essential Skincare, LLC · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7312228

    Cytotoxic indeno and isoindoloisoquinolones

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7312202

    Rationally designed and chemically synthesized promoter for genetic vaccine and gene therapy

    The Board of Regents of the University of Texas System · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7312226

    Substituted tricyclic compounds as protein kinase inhibitors

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7312227

    Compositions useful as inhibitors of JAK and other protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7312231

    Quinuclidine carbamate derivatives and their use as M3 antagonists

    Almirall Prodesfarma S.A. · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7312340

    Synthesis of 2-butyl-3-(1-trityl-1H-tetrazol-5-YL)biphenyl-4-YL)-1,3-diazaspiro[4,4]- non-ene-4-one

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7314624

    Nanoemulsion vaccines

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7314625

    Chimeric protein comprising non-toxic Pseudomonas exotoxin A and Type IV pilin sequences

    The United States as represented by the Secretary of the Department of Health and Human Services · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7314887

    Thrombopoietin activity modulating compounds and methods

    Ligand Pharmaceuticals Incorporated · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7314615

    IκB Kinase-β (IKKβ) binding antibodies and methods of using same

    The Regents of the University of California · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7314618

    Antibodies to fibroblast growth factor (FGF23)

    Ludwig-Maximilians-Universitat Munchen · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7314911

    Prostate hyperplasia therapy

    The Board of Regents of the University of Texas System · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7314731

    Method for selecting therapeutic agents for cancer

    Precision Therapeutics, Inc. · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7314631

    Use of recombinant live-attenuated parainfluenza virus (PIV) as a vector to protect against disease caused by PIV and respiratory syncytial virus (RSV)

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7314632

    Pseudomonas exotoxin A-like chimeric immunogens

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7314754

    Polynucleotide encoding the hOT7T175 G protein coupled receptor

    Takeda Pharmaceutical Company Limited · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7314858

    Retrocyclins: antiviral and antimicrobial peptides

    The Regents of the University of California · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7314885

    Pyrrole compounds useful as kinase inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7314917

    Modified vitamin K-dependent polypeptides

    Regents of the University of Minnesota · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7314956

    Multifunctional carrier for the delivery of a pharmacological agent or genetic material into a cell

    Vaxim, Inc. · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7317020

    Isolation and structure of Cribrostatin 6

    ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA · Granted Tue Jan 08 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7317127

    Process for the optical resolution and recycling of tomoxetine

    Teva Pharmaceutical Fine Chemicals S.R.L. · Granted Tue Jan 08 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7316811

    Multi-arm polypeptide-poly (ethylene glycol) block copolymers as drug delivery vehicles

    Nektar Therapeutics AL, Corporation · Granted Tue Jan 08 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7317022

    Benzoimidazolone-carboxamide compounds as 5-HT4 receptors agonists

    Theravance, Inc. · Granted Tue Jan 08 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7317023

    Diaryl ether β2 adrenergic receptor agonists

    Theravance, Inc. · Granted Tue Jan 08 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7317086

    Basal cell carcinoma tumor suppressor protein

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Jan 08 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7317102

    Diarylmethyl and related compounds

    Theravance, Inc. · Granted Tue Jan 08 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7318861

    Effect pigment

    BASF CATALYSTS LLC · Granted Tue Jan 15 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7319015

    Methods and compositions for using alveolar macrophage phospholipase A2

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jan 15 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7319000

    Compositions and methods for eliciting immune or anti-infective responses

    The Board of Regents of the University of Texas System · Granted Tue Jan 15 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7319091

    Human derived monocyte attracting purified protein product useful in a method of treating infection and neoplasms in a human body, and the cloning of full length cDNA thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jan 15 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7319134

    Regulation of transcription factor, NF-IL6/LAP

    The Regents of the University of California · Granted Tue Jan 15 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7319171

    Sertraline hydrochloride form II and methods for the preparation thereof

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Jan 15 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7321063

    Sulfonamide inhibitors of aspartyl protease

    Vertex Pharmaceuticals Incorporated · Granted Tue Jan 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7321065

    Thyronamine derivatives and analogs and methods of use thereof

    The Regents of the University of California · Granted Tue Jan 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7320990

    Crystalline form of a biphenyl compound

    Theravance, Inc. · Granted Tue Jan 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7320991

    Analogs of thalidomide as potential angiogenesis inhibitors

    The United States of America as Represented by The Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology Transfer · Granted Tue Jan 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7320783

    Methods and compositions for the enhancement of wound healing

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jan 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7320965

    Compositions and methods for inhibiting expression of Huntingtin gene

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jan 22 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 17 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7323174

    Modulation of immune response and methods based thereon

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jan 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7323541

    Polypeptide DNA thereof and use of the same

    Takeda Pharmaceutical Company Limited · Granted Tue Jan 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7323165

    Production of pancreatic islet cells and delivery of insulin

    The Regents of the University of California · Granted Tue Jan 29 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 24 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.