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Intelligence · Patents

Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,253

Quick answer

1,253 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7306806

    Recombinant P. falciparum merozoite protein-142 vaccine

    The United States of America as represented by the Secretary of the Army · Granted Tue Dec 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7306914

    Protein fragment complementation assays in whole animals applications to drug efficacy, ADME, cancer biology, immunology, infectious disease and gene therapy

    Odyssey Thera Inc. · Granted Tue Dec 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7307075

    Tetrahydroquinoline analogues as muscarinic agonists

    ACADIA Pharmaceuticals Inc. · Granted Tue Dec 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7307103

    Sodium dodecyl sulfate compositions for inactivating prions

    The Regents of the University of California · Granted Tue Dec 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7309483

    Method of treatment using Tie2 ligand2

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7309774

    Antiplasmin cleaving enzyme

    The Board of Regents of the University of Oklahoma · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7309692

    Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1

    The Board of Regents of the University of Texas System · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7309694

    Modified cytokines for use in cancer therapy

    FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7309495

    Hemorrhagic feline calicivirus

    The Regents of the University of California · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7309693

    Preventives and remedies for pulmonary hypertension

    Takeda Chemical Industries Ltd. · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7309702

    Arylpiperazines having activity at the serotonin 1A receptor

    Avera Pharmaceuticals, Inc. · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7309716

    Benzimidazoles useful as modulators of ion channels

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7309792

    Dimeric small molecule potentiators of apoptosis

    The Board of Regents of the University of Texas System · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7311921

    Multi-subtype FIV vaccines

    The Regents of the University of California · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7312301

    Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof

    Nektar Therapeutics AL, Corporation · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7311911

    Methods for inhibiting angiogenesis

    The Regents of the University of California · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7311916

    Methods of eliciting broadly neutralizing antibodies targeting HIV-1 gp41

    The Government of the United States of American, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7312198

    Protein compositions for promoting wound healing and skin regeneration

    Essential Skincare, LLC · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7312228

    Cytotoxic indeno and isoindoloisoquinolones

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7312202

    Rationally designed and chemically synthesized promoter for genetic vaccine and gene therapy

    The Board of Regents of the University of Texas System · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7312226

    Substituted tricyclic compounds as protein kinase inhibitors

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7312227

    Compositions useful as inhibitors of JAK and other protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7312231

    Quinuclidine carbamate derivatives and their use as M3 antagonists

    Almirall Prodesfarma S.A. · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7312340

    Synthesis of 2-butyl-3-(1-trityl-1H-tetrazol-5-YL)biphenyl-4-YL)-1,3-diazaspiro[4,4]- non-ene-4-one

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Dec 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. WO 2007147454

    SYNTHÈSE CHIMIQUE DE LA CU-64ASP (CUIVRE-64ASPARAGINASE ; [64CU]ASPARARAGINASE) POUR PET SCAN ET RADIOTHÉRAPIE

    A C O M ADVANCED CT ONCOLOGY M [IT] · Granted Thu Dec 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Dec 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7314624

    Nanoemulsion vaccines

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7314625

    Chimeric protein comprising non-toxic Pseudomonas exotoxin A and Type IV pilin sequences

    The United States as represented by the Secretary of the Department of Health and Human Services · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7314887

    Thrombopoietin activity modulating compounds and methods

    Ligand Pharmaceuticals Incorporated · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7314615

    IκB Kinase-β (IKKβ) binding antibodies and methods of using same

    The Regents of the University of California · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7314618

    Antibodies to fibroblast growth factor (FGF23)

    Ludwig-Maximilians-Universitat Munchen · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7314911

    Prostate hyperplasia therapy

    The Board of Regents of the University of Texas System · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7314731

    Method for selecting therapeutic agents for cancer

    Precision Therapeutics, Inc. · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7314631

    Use of recombinant live-attenuated parainfluenza virus (PIV) as a vector to protect against disease caused by PIV and respiratory syncytial virus (RSV)

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7314632

    Pseudomonas exotoxin A-like chimeric immunogens

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7314754

    Polynucleotide encoding the hOT7T175 G protein coupled receptor

    Takeda Pharmaceutical Company Limited · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7314858

    Retrocyclins: antiviral and antimicrobial peptides

    The Regents of the University of California · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7314885

    Pyrrole compounds useful as kinase inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7314917

    Modified vitamin K-dependent polypeptides

    Regents of the University of Minnesota · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7314956

    Multifunctional carrier for the delivery of a pharmacological agent or genetic material into a cell

    Vaxim, Inc. · Granted Tue Jan 01 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. CA 2653382

    COMPOSITION STABILISEE COMPRENANT DES INHIBITEURS DE L'ECA

    ALPHAPHARM PTY LTD [AU] · Granted Thu Jan 03 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Dec 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7317020

    Isolation and structure of Cribrostatin 6

    ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA · Granted Tue Jan 08 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7317127

    Process for the optical resolution and recycling of tomoxetine

    Teva Pharmaceutical Fine Chemicals S.R.L. · Granted Tue Jan 08 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7316811

    Multi-arm polypeptide-poly (ethylene glycol) block copolymers as drug delivery vehicles

    Nektar Therapeutics AL, Corporation · Granted Tue Jan 08 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7317022

    Benzoimidazolone-carboxamide compounds as 5-HT4 receptors agonists

    Theravance, Inc. · Granted Tue Jan 08 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7317023

    Diaryl ether β2 adrenergic receptor agonists

    Theravance, Inc. · Granted Tue Jan 08 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7317086

    Basal cell carcinoma tumor suppressor protein

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Jan 08 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7317102

    Diarylmethyl and related compounds

    Theravance, Inc. · Granted Tue Jan 08 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 03 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7318861

    Effect pigment

    BASF CATALYSTS LLC · Granted Tue Jan 15 2008 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 10 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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