🇺🇸 FDA

Intelligence · Patents

Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7070957

    STARS—a muscle-specific actin-binding protein

    The Board of Regents of the University of Texas System · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7070788

    Follicle stimulating hormone superagonists

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7070956

    Peptides and derivatives thereof showing cell attachment, spreading and detachment activity

    REGENBiotech, Inc. · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7070971

    Glycosyl sulfotransferases GST-4α, GST-4β, and GST-6

    The Regents of the University of California · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7070972

    Janus family kinases and identification of immune modulators

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7070973

    Butyrylcholinesterase variants and methods of use

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7070975

    Protein and DNA thereof

    Takeda Chemical Industries Ltd. · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7071168

    Anti-cancer compounds and methods related thereto

    The Regents of the University of Colorado · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7071200

    Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

    Neurocrine Biosciences, Inc. · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7071205

    5-cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds

    Ligand Pharmaceuticals Incorporated · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7071224

    Diphenylmethyl compounds useful as muscarinic receptor antagonists

    Theravance, Inc. · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7071318

    Methods and compositions for stabilizing microtubules and intermediate filaments in striated muscle cells

    The Board of Regents of the University of Texas System · Granted Tue Jul 04 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 29 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7074410

    Modified HCV peptide vaccines

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jul 11 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7074765

    Synthetic peptide analogs of Arg-Pro-Pro-Gly-Phe as selective inhibitors of thrombin and thrombin activation of protease activated receptors 1 and 4

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jul 11 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7074893

    Methods and compositions for the treatment of diseases associated with signal transduction aberrations

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jul 11 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7074761

    Peptides and production and use thereof

    Takeda Chemical Ind., Ltd. · Granted Tue Jul 11 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7073512

    Adhesion prevention and an endoscopic insufflation system therefor

    Saturnus AG · Granted Tue Jul 11 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7074554

    Antibodies specific for NEBR1 and methods of use thereof

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Jul 11 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7074760

    Polyacid glycopeptide derivatives

    Theravance, Inc. · Granted Tue Jul 11 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7074782

    Carbamate caspase inhibitors and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 11 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7074900

    Alleviation of the allergenic potential of airborne and contact allergens by thioredoxin

    The Regents of the University of California · Granted Tue Jul 11 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7074924

    Pyrazolopyrimidines as cyclin dependent kinase inhibitors

    Pharmacopeia Drug Discovery, Inc. · Granted Tue Jul 11 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7074890

    Process for preparing glycopeptide phosphonate derivatives

    Theravance, Inc. · Granted Tue Jul 11 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7074938

    Method for the synthesis of soritin compounds

    The Regents of the University of California · Granted Tue Jul 11 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 06 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7078209

    CAK inhibitors and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 18 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7078412

    Quinuclidine derivatives and medicinal compositions containing the same

    Almirall Prodesfarma S.A. · Granted Tue Jul 18 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7078033

    Urinary tract tissue graft compositions and methods for producing same

    The Board of Regents of the University of Oklahoma · Granted Tue Jul 18 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7078037

    Peptides and DNA encoding the peptides useful for immunizations against Coccidioides spp. infections

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jul 18 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7078048

    Method and compositions for treating rosacea

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jul 18 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7078182

    TAO protein kinase polypeptides and methods of use therefor

    The Board of Regents of the University of Texas System · Granted Tue Jul 18 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7078223

    Process for the preparation of pseudomonic acid a antibiotic by microbiological method

    TEVA Gyógyszergyár Zártkörüen Müködö Részvénytárasaság · Granted Tue Jul 18 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7078496

    Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith

    Nektar Therapeutics AL, Corporation · Granted Tue Jul 18 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7078507

    Synthetic genes for malarial proteins and methods of use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jul 18 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7078525

    Pyrazolopyrimidines as cyclin dependent kinase inhibitors

    Pharmacopeia Drug Discovery, Inc. · Granted Tue Jul 18 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7078540

    Substituted aromatic-ring compounds, process for producing the same, and use

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 18 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7078508

    Ixodes scapularis tissue factor pathway inhibitor

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jul 18 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7078552

    Combretastatin A-1 phosphate and combretastatin B-1 phosphate prodrugs

    THE ARIZONA BOARD OF REGENTS · Granted Tue Jul 18 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 13 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7081518

    Anti-mesothelin antibodies having high binding affinity

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jul 25 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 20 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7081529

    Recombinant vaccine against botulinum neurotoxin

    The United States of America as represented by the Secretary of the Army · Granted Tue Jul 25 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 20 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7081452

    Scorpionate-like pendant macrocyclic ligands, complexes and compositions thereof, and methods of using same

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jul 25 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 20 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7081457

    Cyclothiocarbamate derivatives as progesterone receptor modulators

    Ligand Pharmaceuticals Incorporated · Granted Tue Jul 25 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 20 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7081459

    Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

    Neurocrine Biosciences, Inc. · Granted Tue Jul 25 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 20 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7081474

    Drugs to improve synaptic transmission

    The Regents of the University of California · Granted Tue Jul 25 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 20 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7081475

    Wortmannin analogs and methods of using same

    Arizona Board of Regents, Acting on Behalf of the University of Arizona · Granted Tue Jul 25 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 20 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7081524

    O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jul 25 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 20 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7083787

    Yeast-dendritic cell vaccines and uses thereof

    The Regents of the University of Colorado · Granted Tue Aug 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 27 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7084159

    Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Aug 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 27 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7083970

    Methods and compositions for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs

    The Regents of the University of California · Granted Tue Aug 01 2006 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 27 2026 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.