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Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7297523

    Human elongase genes and uses thereof

    Xenon Pharmaceuticals Inc. · Granted Tue Nov 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7297488

    Identifying and testing antisense oligonucleotides that inhibit telomerase reverse transcriptase

    The Regents of the University of Colorado · Granted Tue Nov 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7300935

    Thienopyrimidine compounds and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Nov 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7300660

    Abundant extracellular products and methods for their production and use

    The Regents of the University of California · Granted Tue Nov 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7300940

    Integrin α-v β-3 antagonists for use in imaging and therapy

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Nov 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7300650

    Reovirus for the treatment of neoplasia

    ONCOLYTICS BIOTECH INC. · Granted Tue Nov 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7300653

    Method of treating corneal transplant rejection

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Nov 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7300654

    Method of treating corneal transplant rejection in high risk keratoplasty patients

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Nov 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7300919

    Pulmonary delivery of active fragments of parathyroid hormone

    Nektar Therapeutics · Granted Tue Nov 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7300920

    Antiangiogenic peptide agents

    The Regents of the University of California · Granted Tue Nov 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7300915

    Use of erythropoietin and erythropoietin mimetics for the treatment of neuropathic pain

    The Regents of the University of California · Granted Tue Nov 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7300774

    Multimeric fusion proteins of the TNF superfamily ligands

    The Regents of the University of California · Granted Tue Nov 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7300928

    Benzimidazolidinone derivatives as muscarinic agents

    ACADIA Pharmaceuticals Inc. · Granted Tue Nov 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7300949

    Thiazolopyrazoles and methods of their use

    LEXICON PHARMACEUTICALS, INC. · Granted Tue Nov 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7301024

    Crystalline forms of gatifloxacin and processes for preparation

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Nov 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7301004

    Process for preparing glycopeptide phosphonate derivatives

    Theravance, Inc. · Granted Tue Nov 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7303747

    Use of VEGF inhibitors for treatment of eye disorders

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7304071

    Protein kinase inhibitors and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7303746

    Methods of treating eye disorders with modified chimeric polypeptides

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7303887

    Mule: Mcl-1 ubiquitination ligase E3

    The Board of Regents of the University of Texas System · Granted Tue Dec 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7303748

    Method of treating eye injury with local administration of a VEGF inhibitor

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7303751

    Anti-plasmodium compositions and methods of use

    The Government of the United States of American, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7303754

    MVA expressing modified HIV envelope, gag, and pol genes

    The Government of the United States of American, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7303881

    Antigen delivery compositions and methods of use

    PDS Biotechnology Corporation · Granted Tue Dec 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7304061

    Heterocyclic inhibitors of ERK2 and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7304069

    Hydrate of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5α]-pyrimidin-7-yl}phenyl)acetamide and processes and methods related thereto

    Neurocrine Biosciences, Inc. · Granted Tue Dec 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7304079

    Substituted indolealkanoic acids

    The Institute for Pharmaceutical Discovery, LLC · Granted Tue Dec 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7304127

    Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use

    UNITED STATES OF AMERICA, AS REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES · Granted Tue Dec 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7304080

    Substituted 1,2,4-oxadiazoles, compositions and methods of use

    PTC THERAPEUTICS, INC. · Granted Tue Dec 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7306799

    Use of VEGF inhibitors for treatment of eye disorders

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7306804

    HIV-specific T-cell induction

    The Board of Regents of the University of Texas System · Granted Tue Dec 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7306808

    Orientia tsutsugamushi truncated recombinant outer membrane protein (r47) and (r57) vaccines diagnostics and therapeutics for scrub typhus

    United States of America as represented by the Secretary of the Air Force · Granted Tue Dec 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7306946

    Antifungal polypeptides

    The Regents of the University of California · Granted Tue Dec 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7306627

    Acellular matrix grafts of collagen and elastic fiber

    The Regents of the University of California · Granted Tue Dec 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7306632

    Leave-in color conditioner

    HairMarker LLC · Granted Tue Dec 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7306787

    Engineered particles and methods of use

    Nektar Therapeutics · Granted Tue Dec 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7306806

    Recombinant P. falciparum merozoite protein-142 vaccine

    The United States of America as represented by the Secretary of the Army · Granted Tue Dec 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7306914

    Protein fragment complementation assays in whole animals applications to drug efficacy, ADME, cancer biology, immunology, infectious disease and gene therapy

    Odyssey Thera Inc. · Granted Tue Dec 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7307075

    Tetrahydroquinoline analogues as muscarinic agonists

    ACADIA Pharmaceuticals Inc. · Granted Tue Dec 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7307103

    Sodium dodecyl sulfate compositions for inactivating prions

    The Regents of the University of California · Granted Tue Dec 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7309483

    Method of treatment using Tie2 ligand2

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7309774

    Antiplasmin cleaving enzyme

    The Board of Regents of the University of Oklahoma · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7309692

    Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1

    The Board of Regents of the University of Texas System · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7309694

    Modified cytokines for use in cancer therapy

    FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7309495

    Hemorrhagic feline calicivirus

    The Regents of the University of California · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7309693

    Preventives and remedies for pulmonary hypertension

    Takeda Chemical Industries Ltd. · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7309702

    Arylpiperazines having activity at the serotonin 1A receptor

    Avera Pharmaceuticals, Inc. · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7309716

    Benzimidazoles useful as modulators of ion channels

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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