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Intelligence · Patents

Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,253

Quick answer

1,253 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7276643

    Transgenic animals, cell lines derived therefrom, and methods for screening for anti-amyloidogenic agents

    The Regents of the University of California · Granted Tue Oct 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7276502

    Thiazoles useful as inhibitors of protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Oct 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7279320

    Curlicue vaccine strain of Bacillus anthracis

    United States Army as Represented by the Secretary of the Army · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7279469

    Diaminotriazoles useful as inhibitors of protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7279159

    VEGF inhibitor polypeptides

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7279163

    Water-in-oil emulsion vaccines

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7279294

    Tumor markers in ovarian cancer

    The United States of America as represented by the Secretary, Dept. of Health and Human Services, NIH · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7279306

    Stable (fixed) forms of viral capsid proteins, and viral capsid protein fusions, preferably papillomavirus L1 proteins, and uses thereof

    The Regents of the University of Colorado · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7279326

    Composition for delivery of a mitochondrial genome to a cell

    Northwestern University · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7279322

    Electrospraying apparatus and method for coating particles

    Regents of the University of Minnesota · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7279458

    Cross-linked glycopeptide-cephalosporin antibiotics

    Theravance, Inc. · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7279466

    Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof

    THE ARIZONA BOARD OF REGENTS · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7279571

    Methods of preparing pimecrolimus

    TEVA Gyógyszergyár Zártkörüen Müködö Részvénytárasaság · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7279476

    Pyrazole-derived kinase inhibitors and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7282206

    Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Oct 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7282482

    NGF for the prevention of demyelination in the nervous system

    The Regents of the University of California · Granted Tue Oct 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7282205

    Anti-hepatitis A virus antibodies

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Oct 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7282563

    Opioid receptors and methods of use

    The Regents of the University of California · Granted Tue Oct 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7285683

    Bicyclic and tricyclic cannabinoids

    UNIVERSITY OF CONNECTICUT · Granted Tue Oct 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7285415

    Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury

    The Regents of the University of California · Granted Tue Oct 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7285542

    Hyperthermic inducible expression vectors for gene therapy and methods of use thereof

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Oct 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7285281

    Mutant forms of cholera holotoxin as an adjuvant

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Oct 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7285527

    Tumor radiosensitization using gene therapy

    The Regents of the University of California · Granted Tue Oct 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7285383

    Method for selective inactivation of viral replication

    Rigel Pharmaceuticals, Inc. · Granted Tue Oct 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7285532

    Therapeutic method for treating bone formation diseases

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Oct 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7285363

    Photoactivators, methods of use, and the articles derived therefrom

    UNIVERSITY OF CONNECTICUT · Granted Tue Oct 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7285534

    Corticotropin-releasing hormone analogs and their uses

    The Regents of the University of California · Granted Tue Oct 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7285556

    Thienopyrimidine-based inhibitors of the src family

    The Board of Regents of the University of Texas System · Granted Tue Oct 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7285564

    Substituted 4-amino-1-(pyridylmethyl)piperidine and related compounds

    Theravance, Inc. · Granted Tue Oct 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7285668

    Process for the crystallization of (R)- or (S)-lansoprazole

    Takeda Pharmaceutical Company Limited · Granted Tue Oct 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7285639

    Antibody to telomerase reverse transcriptase

    The Regents of the University of Colorado · Granted Tue Oct 23 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 18 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. EP 1847258

    Partialglyceride als Schmiermittel für pharmazeutische Zusammensetzungen enthaltend Thieno[3,2-c]pyridin-Derivate

    RENTSCHLER GMBH [DE] · Granted Wed Oct 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Oct 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7288254

    Use of immunotoxins to induce immune tolerance to pancreatic islet transplantation

    The United States of America as Represented by the Secretary Department of Health and Human Services (NIH) · Granted Tue Oct 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7288624

    Inhibitors of interleukin-1β converting enzyme

    Vertex Pharmaceuticals Incorporated · Granted Tue Oct 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7288654

    Fused-ring pyridine derivative, process for producing the same, and use

    Takeda Pharmaceutical Company Limited · Granted Tue Oct 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7288671

    Interleukin-1 and tumor necrosis factor-α modulators, synthesis of said modulators and their enantiomers and methods of using said modulators

    The Regents of the University of California · Granted Tue Oct 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7288246

    Method of alleviating chronic pain via peripheral glutaminase regulation

    The Board of Regents of the University of Oklahoma · Granted Tue Oct 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7288266

    Liposome complexes for increased systemic delivery

    UNITED STATES OF AMERICA, AS REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES · Granted Tue Oct 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7288369

    Replication competent hepatitis C virus and methods of use

    The Board of Regents of the University of Texas System · Granted Tue Oct 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7288258

    Polyepitopic protein fragments of the E6 and E7 proteins of HPV, their production and their use particularly in vaccination

    Peptide Immune Ligands · Granted Tue Oct 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7288263

    Compositions and methods for treatment of skin discoloration

    Evera Laboratories, LLC · Granted Tue Oct 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7288608

    Degradable thiol-ene polymers

    The Regents of the University of Colorado · Granted Tue Oct 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7288657

    Biphenyl compounds useful as muscarinic receptor antagonists

    Theravance, Inc. · Granted Tue Oct 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7288646

    USPA2 nucleic acid of Moraxella catarrhalis

    The Board of Regents of the University of Texas System · Granted Tue Oct 30 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 25 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. CA 2648495

    FORMULATIONS A LIBERATION CONTROLEE QUI COMPRENNENT UNE OU PLUSIEURS UNITES DISCRETES NON ENROBEES ET UNE MATRICE A LIBERATION RETARDEE

    ALPHAPHARM PTY LTD [AU] · Granted Thu Nov 01 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. AU 2007242062

    Pharmaceutical compositions of oxcarbazepine with a median particle size of 15 to 30 microns

    ALPHAPHARM PTY LTD [AU] · Granted Thu Nov 01 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. IT MI20070164

    CEROTTO TRANSDERMICO

    AXXONIS PHARMA AG · Granted Tue Nov 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7291699

    Product and methods for diagnosis and therapy for cardiac and skeletal muscle disorders

    The Regents of the University of Colorado · Granted Tue Nov 06 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 01 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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