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Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7264947

    Activity dependent neurotrophic factor III (ADNF III)

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Sep 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 30 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7265083

    Treatment of idiopathic pulmonary fibrosis using IP-10

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Sep 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 30 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7265086

    Glycopeptide carboxy-saccharide derivatives

    Theravance, Inc. · Granted Tue Sep 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 30 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7265133

    Biphenyl compounds useful as muscarinic receptor antagonists

    Theravance, Inc. · Granted Tue Sep 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 30 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7265157

    Sustained release compositions, process for producing the same and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Sep 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 30 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7265186

    Multi-arm block copolymers as drug delivery vehicles

    Nektar Therapeutics AL, Corporation · Granted Tue Sep 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 30 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7265215

    DNA or RNA encoding a recombinant dengue envelope protein

    The United States of America as represented by the Secretary of the Army · Granted Tue Sep 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 30 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7268212

    Ligand of G protein-coupled receptor protein and DNA thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Sep 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7267978

    Chimeric transcriptional regulatory element compositions and methods for increasing prostate-targeted gene expression

    The Regents of the University of California · Granted Tue Sep 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7268136

    Compositions useful as inhibitors of protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7267823

    Ebola peptides and immunogenic compositions containing same

    The United States of America as represented by the Secretary of the Army · Granted Tue Sep 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7268222

    Polynucleotides encoding human transporter proteins

    LEXICON PHARMACEUTICALS, INC. · Granted Tue Sep 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7267941

    Cyanovirin variant-polymer conjugates

    Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health · Granted Tue Sep 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7268118

    Thymosin β4 compositions

    United States of America as represented by the Secretary of the Air Force · Granted Tue Sep 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7268148

    Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Sep 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7268122

    Use of oversulfated polysaccharides as inhibitors of HIV

    FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR · Granted Tue Sep 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7268232

    Androgen receptor modulators and method of treating disease using the same

    ACADIA Pharmaceuticals Inc. · Granted Tue Sep 11 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 06 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7271148

    Inhibition of cellular proteases

    The Board of Regents of the University of Texas System · Granted Tue Sep 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7271150

    Modified growth hormone

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue Sep 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7271179

    Inhibitors of JAK protein kinase

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7271181

    Inhibitors of p38

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7270960

    Diagnosis of ovarian carcinomas

    PACIFIC NORTHWEST RESEARCH INSTITUTE · Granted Tue Sep 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7270994

    Lactobacillus casei Bd-II stain and used to reduce blood cholesterol

    Shanghai Bright Dairy & Food Co. Ltd. · Granted Tue Sep 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7271161

    Platinum complexes as antitumor agents in combination with biochemical modulation

    The Board of Regents of the University of Texas System · Granted Tue Sep 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7271182

    Salts of benzimidazole compound and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Sep 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7271186

    Nanomolar β-lactamase inhibitors

    Northwestern University · Granted Tue Sep 18 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 13 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7273851

    Tri-peptide hepatitis C serine protease inhibitors

    Enanta Pharmaceuticals, Inc. · Granted Tue Sep 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7273369

    Curing light

    DISCUS DENTAL, LLC · Granted Tue Sep 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7273713

    Methods of modulating mitochondrial NAD-dependent deacetylase

    The Regents of the University of California · Granted Tue Sep 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7273613

    Diagnostics and therapy of Epstein-Barr virus in autoimmune disorders

    The Board of Regents of the University of Oklahoma · Granted Tue Sep 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7273710

    Method for screening MCH receptor antagonist/agonist

    Takeda Pharmaceutical Company Limited · Granted Tue Sep 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7273857

    Benzimidazolidinone derivatives as muscarinic agents

    ACADIA Pharmaceuticals Inc. · Granted Tue Sep 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7273853

    6-11 bicyclic ketolide derivatives

    Enanta Pharmaceuticals, Inc. · Granted Tue Sep 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7273885

    Inhibitors of serine proteases, particularly HCV NS3-NS4A protease

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7273923

    Zinc finger proteins for DNA binding and gene regulation in plants

    Sangamo Biosciences, Inc. · Granted Tue Sep 25 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 20 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7276527

    5-pyridyl-1,3-azole compounds, process for producing the same and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Oct 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7276352

    Induction of β cell differentiation in human cells by stimulation of the GLP-1 receptor

    The Regents of the University of California · Granted Tue Oct 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7276348

    Compositions and methods relating to F1F0-ATPase inhibitors and targets thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Oct 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7276227

    Obligate domain-swapped dimer of cyanovirin with enhanced anti-viral activity

    UNITED STATES OF AMERICA, AS REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES · Granted Tue Oct 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7276629

    Hydrogenation of imine intermediates of sertraline with catalysts

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Oct 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7276643

    Transgenic animals, cell lines derived therefrom, and methods for screening for anti-amyloidogenic agents

    The Regents of the University of California · Granted Tue Oct 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7276502

    Thiazoles useful as inhibitors of protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Oct 02 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 27 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7279320

    Curlicue vaccine strain of Bacillus anthracis

    United States Army as Represented by the Secretary of the Army · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7279469

    Diaminotriazoles useful as inhibitors of protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7279159

    VEGF inhibitor polypeptides

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7279163

    Water-in-oil emulsion vaccines

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7279294

    Tumor markers in ovarian cancer

    The United States of America as represented by the Secretary, Dept. of Health and Human Services, NIH · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7279306

    Stable (fixed) forms of viral capsid proteins, and viral capsid protein fusions, preferably papillomavirus L1 proteins, and uses thereof

    The Regents of the University of Colorado · Granted Tue Oct 09 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 04 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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