Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,253

Quick answer

1,253 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7252817

    Viruses for the treatment of cellular proliferative disorders

    ONCOLYTICS BIOTECH INC. · Granted Tue Aug 07 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 02 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7253187

    Heterocyclic inhibitors of ERK2 and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Aug 07 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 02 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7253275

    Porin B (PorB) as a therapeutic target for prevention and treatment of infection by Chlamydia

    The Regents of the University of California · Granted Tue Aug 07 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 02 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7252819

    Methods and compositions for correction of cardiac conduction disturbances

    The Regents of the University of California · Granted Tue Aug 07 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 02 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7252989

    Adenovirus supervector system

    The Board of Regents of the University of Texas System · Granted Tue Aug 07 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 02 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7253147

    Modified serum albumin with reduced affinity for nickel and copper

    New Century Pharmaceuticals, Inc. · Granted Tue Aug 07 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 02 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7252929

    Methods for identifying alpha PDGFR agonists and antagonists

    United State of America, As Represented by the Secretary, Dept. of Health and Human Services · Granted Tue Aug 07 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 02 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7252996

    Ancillary composition for the preparation of committed mature dentritic cells

    I.D.M. Immuno-Designed Molecules · Granted Tue Aug 07 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 02 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7253171

    Urea derivatives as integrin α4 antagonists

    Laboratories Almirall, S.A. · Granted Tue Aug 07 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 02 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7253185

    Amino ceramide-like compounds and therapeutic methods of use

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Aug 07 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 02 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7253273

    Treatment of neuropathic pain with zinc finger proteins

    Sangamo Biosciences, Inc. · Granted Tue Aug 07 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 02 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7253341

    Denaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same, their uses and methods of increasing a specific activity thereof

    Fulcrum SP Ltd. · Granted Tue Aug 07 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 02 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7256004

    Variants of humanized anti-carcinoma monoclonal antibody CC49

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7256190

    Thiazole compounds useful as inhibitors of protein kinase

    Vertex Pharmaceuticals Incorporated · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7256265

    Streptococcal C5a peptidase vaccine

    Regents of the University of Minnesota · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7256281

    Recombinant P. falciparum merozoite protein-142 vaccine

    The United States of America as represented by the Secretary of the Army · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7256195

    Preparation of risperidone

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7255850

    Methods for measuring rates of reserve cholesterol transport in vivo, as an index of anti-atherogenesis

    The Regents of the University of California · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7256028

    Methods for screening compounds that modulate lipid metabolism

    Xenon Genetics Inc. · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7256047

    Measurement of gluconeogenesis and intermediary metabolism using stable isotopes

    The Board of Regents of the University of Texas System · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7256171

    Use of core 2 G1cNAc transferase inhibitors in treating inflammation

    The Regents of the University of California · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7256212

    Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7256204

    Amine compounds, their production and use

    Takeda Pharmaceutical Company Limited · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7256256

    CDK4 binding peptide

    UNITED STATES OF AMERICA, AS REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7256277

    Nucleotide and protein sequence of mammastatin and methods of use

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7256260

    Human p53 mutations and a genetic system in yeast for functional identification of human p53 mutations

    The United States of America as represented by the Secretary, Dept. of Health and Human Services, NIH · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7256279

    Protein having ribonucleotide reductase activity and DNA thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7256294

    Crystalline form of a benzimidazole-carboxamide medicinal compound

    Theravance, Inc. · Granted Tue Aug 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. AU 2002328956

    17alfa, 21-dihydroxypregnene esters as antiandrogenic agents

    CASSIOPEA S P A [IT] · Granted Thu Aug 16 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Aug 11 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7259142

    Redox-stable, non-phosphorylated cyclic peptide inhibitors of SH2 domain binding to target protein, conjugates thereof, compositions and methods of synthesis and use

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue Aug 21 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7259161

    Compositions useful as inhibitors of JAK and other protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Aug 21 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7259153

    Drug formulation and delivery using crystalline methylated cyclodextrins

    Supernus Pharmaceuticals, Inc. · Granted Tue Aug 21 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7258859

    Method for the treatment of multiple sclerosis

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Aug 21 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7258863

    Heterologous protection induced by immunization with invaplex vaccine

    The United States of America as represented by the Secretary of the Army · Granted Tue Aug 21 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7259236

    RBP1L1, a novel retinoblastoma binding protein-related gene encoding an antigenic epitope and methods of using thereof

    The Regents of the University of California · Granted Tue Aug 21 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7259261

    Racemization and enantiomer separation of clopidogrel

    TEVA Gyógyszergyár Zártkörüen Müködö Részvénytárasaság · Granted Tue Aug 21 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7259167

    Antimalarial and antiproliferative pharmacophore models, novel tryptanthrin compounds having increased solubility, and methods of making and using thereof

    The United States of America as represented by the Secretary of the Army · Granted Tue Aug 21 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7259278

    Anti-S-phase tubulin ligands

    Cytoskeleton, Inc. · Granted Tue Aug 21 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 16 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7261896

    Methods for preventing strokes by inducing tolerance to e-selectin

    The United States of America as Represented by The Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology Transfer · Granted Tue Aug 28 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7262185

    Benzazepine derivative, process for producing the same, and use

    Takeda Chemical Industries Ltd. · Granted Tue Aug 28 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7261875

    Dendritic poly (amino acid) carriers and methods of use

    The Board of Regents of the University of Texas System · Granted Tue Aug 28 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7261882

    Methods for treating neuropathic pain by administering IL-10 polypeptides

    The Regents of the University of Colorado · Granted Tue Aug 28 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7262027

    Polypeptide and DNA immunization against Coccidioides spp. infections

    THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS · Granted Tue Aug 28 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7261900

    Recombinant modified Bacillus anthracis protective antigen for use in vaccines

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Aug 28 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7262205

    Biphenyl compounds useful as muscarinic receptor antagonists

    Theravance, Inc. · Granted Tue Aug 28 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7262218

    Forms of pravastatin sodium

    TEVA GYOGYSZERGYAR ZARTKORUEN MUKODO RESZVENYTARSASAG · Granted Tue Aug 28 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7262288

    Nucleic acids encoding human telomerase reverse transcriptase and related homologs

    The Regents of the University of Colorado · Granted Tue Aug 28 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 23 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7264798

    Sensitization of chemotherapeutic agent resistant neoplastic cells with a virus

    ONCOLYTICS BIOTECH INC. · Granted Tue Sep 04 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Aug 30 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.