🇺🇸 FDA

Intelligence · Patents

Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7226937

    Methods for modulating phototoxicity

    Board of Regents, University of Arizona · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7226950

    Sodium channel modulators

    Theravance, Inc. · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7227009

    MT-SP1 polynucleotides and polypeptides

    Catalyst Biosciences, Inc. · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7226991

    Phenylalanine derivatives

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7227010

    Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy

    The United States of America as represented by the Secretary of the Army · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7229628

    Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling

    The Regents of the University of California · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7229627

    Apparatuses and methods for the production of haematophagous organisms and parasites suitable for vaccine production

    Sanaria Inc. · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7229963

    Methods of using deacetylase inhibitors to promote cell differentiation and regeneration

    United States of America as represented by the Secretary of the Department of of Health Services, National Institutes of Health · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7229604

    Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging

    The Board of Regents of the University of Texas System · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7229770

    YKL-40 as a marker and prognostic indicator for cancers

    The Regents of the University of California · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7229826

    Process for ex vivo formation of mammalian bone and uses thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7229949

    Safe delivery system for agriculturally active material

    United Phosphorus Limited · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7229641

    Rapid-melt compositions methods of making same and methods of using same

    Capricorn Pharma Inc. · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7230086

    Assay for YKL-40 as a marker for degradation of mammalian connective tissue matrices

    The Regents of the University of California · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7229995

    Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

    Neurocrine Biosciences, Inc. · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7230004

    Cyclopamine analogues and methods of use thereof

    Infinity Discovery, Inc. · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7229986

    Melanin-concentrating hormone antagonist

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7229972

    3,6-Bicyclolides

    Enanta Pharmaceuticals, Inc. · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7232671

    Pertussis toxin gene: cloning and expression of protective antigen

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 19 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7232887

    Melanoma antigens and their use in diagnostic and therapeutic methods

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 19 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7232566

    Methods for treating HIV infected subjects

    The United States as represented by the Secretary of the Navy · Granted Tue Jun 19 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7232684

    DNA encoding hyaluronan synthase from Pasteurella multocida and methods of use

    The Board of Regents of the University of Oklahoma · Granted Tue Jun 19 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7232570

    ERAAP modulators regulate immune responses

    The Regents of the University of California · Granted Tue Jun 19 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7232890

    AIB1, a novel steroid receptor co-activator

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Jun 19 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7235573

    Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors

    The Regents of the University of California · Granted Tue Jun 26 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 21 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7235644

    Vaccine against Gram-negative bacterial infections

    The United States of America as represented by the Secretary of the Army · Granted Tue Jun 26 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 21 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7235232

    Interferon alpha hybrids

    The Government of the United States of America as represented by the Secretary of the Deptartment of Health and Human Services · Granted Tue Jun 26 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 21 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7235228

    Fluorescent-magnetic nanoparticles with core-shell structure

    United States of America as represented by the Secretary of the Air Force · Granted Tue Jun 26 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 21 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7235365

    Specific binding agents for KSHV vIL-6 that neutralize a biological activity

    The Government of the United States of America as represented by the Secretary of the Deptartment of Health and Human Services · Granted Tue Jun 26 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 21 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7235529

    Brain-associated inhibitor of tissue-type plasminogen activator

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 26 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 21 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7235534

    Antisense strategy to modulate estrogen receptor response (ER α and/or ER β )

    INSTITUT DE CARDIOLOGIE DE MONTREAL · Granted Tue Jun 26 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 21 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7235234

    Bacterial delivery system

    The United States of America as represented by the Secretary of the Army · Granted Tue Jun 26 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 21 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7235236

    Polynucleotide encoding human adenylylcyclase VI and uses thereof for enhancing cardiac function

    The Regents of the University of California · Granted Tue Jun 26 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 21 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7235531

    Tachykinin-like polypeptides and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 26 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 21 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7235577

    Non-peptide inhibition of T-lymphocyte activation and therapies related thereto

    The Regents of the University of California · Granted Tue Jun 26 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 21 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7235691

    Crystalline forms of modafinil

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Jun 26 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 21 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7238525

    Strategy for leukemia therapy

    The Regents of the University of California · Granted Tue Jul 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 28 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7238475

    Apolipoprotein gene involved in lipid metabolism

    The Regents of the University of California · Granted Tue Jul 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 28 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7238489

    Identification of sortase gene

    The Regents of the University of California · Granted Tue Jul 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 28 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7238369

    Cationic liposome delivery of taxanes to angiogenic blood vessels

    The Regents of the University of California · Granted Tue Jul 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 28 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7238366

    Submicron liposome suspensions obtained from preliposome lyophilizates

    The Board of Regents of the University of Texas System · Granted Tue Jul 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 28 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7238708

    Glucose sensor

    The Regents of the University of California · Granted Tue Jul 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 28 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7238713

    Muscarinic agonists

    ACADIA Pharmaceuticals Inc. · Granted Tue Jul 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 28 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7238709

    Therapeutic carbamates

    Theravance, Inc. · Granted Tue Jul 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 28 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7238800

    Peptides and DNA encoding the peptides useful for immunizations against Coccidioides spp. infections

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jul 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 28 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7238673

    Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jul 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 28 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7238716

    Alkanoic acid derivatives process for their production and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 28 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7241785

    Five-membered heterocyclic alkanoic acid derivative

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 10 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.