Wednesday, June 10, 2026

Intelligence · Patents

Expiring patents (≤12 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
645

Quick answer

645 pharmaceutical patents in our index expire within the next 12 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7226937

    Methods for modulating phototoxicity

    Board of Regents, University of Arizona · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 7226950

    Sodium channel modulators

    Theravance, Inc. · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 7226991

    Phenylalanine derivatives

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 7226602

    Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 7226589

    Treatment of diseases by site specific instillation of cells or site specific transformation of cells and kits therefor

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 7226946

    Substituted phenol compounds useful for anesthesia and sedation

    Theravance, Inc. · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 2007128117

    Ultrasound contrast agents and process for the preparation thereof

    BRACCO INT BV [NL] · Granted Thu Jun 07 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jun 02 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 7229972

    3,6-Bicyclolides

    Enanta Pharmaceuticals, Inc. · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 7229628

    Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling

    The Regents of the University of California · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 7229627

    Apparatuses and methods for the production of haematophagous organisms and parasites suitable for vaccine production

    Sanaria Inc. · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 7229826

    Process for ex vivo formation of mammalian bone and uses thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 7229986

    Melanin-concentrating hormone antagonist

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 7230004

    Cyclopamine analogues and methods of use thereof

    Infinity Discovery, Inc. · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 7229995

    Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

    Neurocrine Biosciences, Inc. · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 7230086

    Assay for YKL-40 as a marker for degradation of mammalian connective tissue matrices

    The Regents of the University of California · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 7229641

    Rapid-melt compositions methods of making same and methods of using same

    Capricorn Pharma Inc. · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 7229949

    Safe delivery system for agriculturally active material

    United Phosphorus Limited · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 7229963

    Methods of using deacetylase inhibitors to promote cell differentiation and regeneration

    United States of America as represented by the Secretary of the Department of of Health Services, National Institutes of Health · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 7229770

    YKL-40 as a marker and prognostic indicator for cancers

    The Regents of the University of California · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 7229604

    Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging

    The Board of Regents of the University of Texas System · Granted Tue Jun 12 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. CA 2631716

    CONJUGUES VECTEUR DE CIBLAGE-PHOSPHOLIPIDES

    BRACCO INT BV [NL] · Granted Thu Jun 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jun 09 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.