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Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7217427

    Polymersomes and related encapsulating membranes

    Regents of the University of Minnesota · Granted Tue May 15 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 10 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7217541

    Method of making CS6 antigen vaccine for treating, preventing, or inhibiting enterotoxigenic Escherichia coli infections

    The United States of America as represented by the Secretary of the Army · Granted Tue May 15 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 10 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7217571

    Gene therapy by small fragment homologous replacement

    The Regents of the University of California · Granted Tue May 15 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 10 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7217738

    β2-adrenergic receptor agonists

    Theravance, Inc. · Granted Tue May 15 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 10 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7217739

    Method for inducing cell death with carbonyl scavengers

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue May 15 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 10 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7217795

    Tumor suppressor designated TS10q23.3

    The Board of Regents of the University of Texas System · Granted Tue May 15 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 10 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7217808

    RFRP-3 and DNA thereof

    Takeda Pharmaceutical Company Limited · Granted Tue May 15 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 10 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7217811

    Human gene critical to fertility

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 15 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 10 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7220431

    Methods and compositions for applying pharmacologic agents to the ear

    Regents of the University of Minnesota · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7220739

    Therapeutic application of pro-apoptotic benzodiazepines

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7220419

    Self-assembling recombinant papillomavirus capsid proteins

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7220582

    Stem cells that transform to beating cardiomyocytes

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7220726

    Antifungal pimaricin compositions and therapeutic methods employing same

    The Board of Regents of the University of Texas System · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7220757

    Compositions and methods for topical administration of 2-NH-heteroarylimidazoles

    Replidyne, Inc. · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7220328

    Low-smoke gas generating low order pressure pulse compositions

    United States of America as represented by the Secretary of the Air Force · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7220421

    Moraxella bovis cytotoxin, cytotoxin gene, antibodies and vaccines for prevention and treatment of Moraxella bovis infections

    The Regents of the University of California · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7220558

    Cartilage-derived morphogenetic proteins

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7220583

    Pseudomonas avr and hop proteins, their encoding nucleic acids, and use thereof

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7220719

    Modulation of endogenous gene expression in cells

    Sangamo Biosciences, Inc. · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7220718

    Oral treatment of hemophilia

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7220730

    Cancer specific radiolabeled conjugates regulated by the cell cycle for the treatment and diagnosis of cancer

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7220745

    Heterocyclic compounds useful to treat HCV

    Rigel Pharmaceuticals, Inc. · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7220837

    Modified vitamin K-dependent polypeptides

    Regents of the University of Minnesota · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7220853

    Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to Grb2 or Crk1

    The Board of Regents of the University of Texas System · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7220852

    Coronavirus isolated from humans

    The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention · Granted Tue May 22 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 17 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7223406

    Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder

    The Regents of the University of California · Granted Tue May 29 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 24 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7223388

    Modified reoviral therapy

    The Board of Regents of the University of Texas System · Granted Tue May 29 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 24 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7223787

    Prenylation inhibitors reduce host cell permissiveness to viral replication

    The Board of Regents of the University of Texas System · Granted Tue May 29 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 24 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7223836

    Peptides for chlamydophila pneumoniae vaccine and diagnosis

    The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention · Granted Tue May 29 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 24 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7223783

    Indolinone derivatives

    Theravance, Inc. · Granted Tue May 29 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 24 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7223380

    Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging

    The Board of Regents of the University of Texas System · Granted Tue May 29 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 24 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7223563

    Fibroblast growth factor (FGF23) nucleic acids

    Ludwig-Maximilians-Universitat Munchen · Granted Tue May 29 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 24 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7223424

    Compositions and methods for prostate and kidney health and disorders, an herbal preparation

    Integrated Chinese Medicine Holdings Ltd. · Granted Tue May 29 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 24 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7223726

    Apolipoprotein A-I mutant proteins having cysteine substitutions and polynucleotides encoding same

    The Regents of the University of California · Granted Tue May 29 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 24 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7223585

    Viral purification methods

    ONCOLYTICS BIOTECH INC. · Granted Tue May 29 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 24 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7223571

    Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same

    The Board of Regents of the University of Oklahoma · Granted Tue May 29 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 24 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7223791

    Function regulator for retinoid relative receptor

    Takeda Pharmaceutical Company Limited · Granted Tue May 29 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 24 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7223844

    Broadly cross-reactive neutralizing antibodies against human immunodeficiency virus selected by Env-CD4-co-receptor complexes

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue May 29 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 24 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7223853

    Secreted frizzled related protein fragments

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue May 29 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 24 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7223803

    Polyethylene (glycol) derivatives with proximal reactive groups

    Nektar Therapeutics AL, Corporation · Granted Tue May 29 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 24 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7226589

    Treatment of diseases by site specific instillation of cells or site specific transformation of cells and kits therefor

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7226602

    Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7226946

    Substituted phenol compounds useful for anesthesia and sedation

    Theravance, Inc. · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7227011

    Nucleic acid vaccines for prevention of flavivirus infection

    The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7226588

    Non-toxic mutants of pathogenic gram-negative bacteria

    The Regents of the University of California · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7226609

    Sodium dodecyl sulfate compositions for inactivating prions

    The Regents of the University of California · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7226597

    Mutants of Clostridium difficile toxin B and methods of use

    The Board of Regents of the University of Oklahoma · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7226920

    Aminotriazole compounds useful as inhibitors of protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Jun 05 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 31 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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