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Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7205305

    Inhibitors of p38

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 17 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 12 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7205334

    Chondropsin-class antitumor v-atpase inhibitor compounds, compositions and methods of use thereof

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 17 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 12 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7205411

    Aminopyridine derivatives as mGluR5 antagonists

    Addex Pharmaceuticals S.A. · Granted Tue Apr 17 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 12 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7205005

    Medicament containing epidemium extract for treatment of prostatic hyperplasia and prostatitis

    Bright Future Pharmaceutical Laboratories · Granted Tue Apr 17 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 12 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7204982

    Compositions and methods for treatment and detection of multiple cancers

    The Regents of the University of California · Granted Tue Apr 17 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 12 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7204993

    Streptococcus agalactiae vaccine

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Apr 17 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 12 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7204996

    Method of cancer treatment

    The Board of Regents of the University of Texas System · Granted Tue Apr 17 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 12 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7205006

    Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same

    Prime Pharmaceutical Corporation · Granted Tue Apr 17 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 12 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7205327

    Imidazole and benzimidazole caspase inhibitors and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 17 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 12 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7205380

    Sterically hindered poly (ethylene glycol) alkanoic acids and derivatives thereof

    Nektar Therapeutics AL, Corporation · Granted Tue Apr 17 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 12 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7208471

    Glycopeptide phosphonate derivatives

    Theravance, Inc. · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7208580

    Atomic structure of the hemalbumin complex and its use in designing therapeutic compounds

    New Century Pharmaceuticals, Inc. · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7208289

    Methods of identifying compounds that modulate IL-4 receptor mediated IgE synthesis utilizing a CLLD8 protein

    Rigel Pharmaceuticals, Inc. · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7208145

    Polymeric reagents comprising a ketone or a related functional group

    Nektar Therapeutics AL, Corporation · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7208313

    Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7208161

    Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7208171

    Injectable and bioadhesive polymeric hydrogels as well as related methods of enzymatic preparation

    Northwestern University · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7208154

    Methods and compositions for the treatment of MHC-associated conditions

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7208495

    Benzo-fused 5-membered hetrocycle compounds, process for preparation of the same, and use thereof

    Takeda Pharmaceutical Company Limited · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7208501

    Quinuclidine carbamate derivatives and their use as M3 antagonists

    Almirall Prodesfarma S.A. · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7208515

    Diphenylmethyl compounds useful as muscarinic receptor antagonists

    Theravance, Inc. · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7208478

    Immunostimulatory polynucleotide/immunomodulatory molecule conjugates

    The Regents of the University of California · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7208579

    IL4 receptor antagonists for horse, dog and cat

    The Regents of the University of California · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7208612

    Crystals of LuxP and complexes thereof

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7208600

    Inhibitors of serine proteases, particularly HCV NS3-NS4A proteases

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7208602

    Gamma secretase inhibitors

    Pharmacopeia Drug Discovery, Inc. · Granted Tue Apr 24 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 19 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7211445

    Conjugation of biomolecules using diels-alder cycloaddition

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue May 01 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 26 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7211432

    Recombinant vector expressing multiple costimulatory molecules and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 01 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 26 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7211192

    Hybrid organic-inorganic adsorbents

    The Regents of the University of California · Granted Tue May 01 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 26 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7211252

    Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagonists

    The Board of Regents of the University of Texas System · Granted Tue May 01 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 26 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7211255

    Contraceptives based on SP22 and SP22 antibodies

    United States of America The U.S. Environmental Protection Agency · Granted Tue May 01 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 26 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7211402

    Transcription factor coactivator protein, p/CIP

    The Regents of the University of California · Granted Tue May 01 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 26 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7211599

    Use of etodolac to treat hyperplasia

    The Regents of the University of California · Granted Tue May 01 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 26 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7214512

    Genomic mammary Amyloid a sequence

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue May 08 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 03 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7214687

    Quinuclidine derivatives and medicinal compositions containing the same

    ALMIRALL, LLC · Granted Tue May 08 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 03 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7214784

    Protective antigens for the control of Ixodes species infestations

    The Board of Regents for Oklahoma State University · Granted Tue May 08 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 03 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7214366

    Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules

    Nektar Therapeutics AL, Corporation · Granted Tue May 08 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 03 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7214391

    Botanical extract compositions and process for preparing same

    USANA Health Sciences, Inc. · Granted Tue May 08 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 03 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7214495

    Screening method

    Takeda Pharmaceutical Company Limited · Granted Tue May 08 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 03 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7214519

    Screening method for identifying heme independent modulators of soluble guanylyl cyclase (sGC) activity using αβCys105 mutant sGC

    The Board of Regents of the University of Texas System · Granted Tue May 08 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 03 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7214690

    Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods

    Ligand Pharmaceuticals Incorporated · Granted Tue May 08 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 03 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7214524

    Marek's disease virus vaccine

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue May 08 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 03 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7216041

    Methods of using the structure coordinates of molecules comprising an IMPDH-like binding pocket

    Vertex Pharmaceuticals Incorporated · Granted Tue May 08 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 03 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7214787

    Recombinant vaccine against botulinum neurotoxin

    The United States of America as represented by the Secretary of the Army · Granted Tue May 08 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 03 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7217719

    Spiroazacyclic compounds as monoamine receptor modulators

    ACADIA Pharmaceuticals Inc. · Granted Tue May 15 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 10 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7217785

    Cysteine-containing peptides having antioxidant properties

    The Regents of the University of California · Granted Tue May 15 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 10 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7217812

    Extraneous DNA sequence that facilitates hantavirus gene expression

    The United States of America as represented by the Secretary of the Army · Granted Tue May 15 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 10 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7217418

    Multivalent dengue virus vaccine

    The United States of America as represented by the Secretary of the Army · Granted Tue May 15 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 10 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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