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Expiring patents (≤24 months)

Patent cliff watchlist — pharmaceutical patents approaching loss of exclusivity.

Patents
1,230

Quick answer

1,230 pharmaceutical patents in our index expire within the next 24 months. Use year facets below for annual patent-cliff planning linked to company and drug profiles.

  1. US 7192546

    Methods of forming shaped articles from suspensions

    Albright & Wilson (Australia) Limited · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 7192934

    Vaccines for blocking transmission of Plasmodium vivax

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 7193075

    Sequences upstream of the CARP gene, vectors containing them and uses thereof

    The Regents of the University of California · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 7192583

    Methods for modulating bone mineralization

    Darwin Discovery Limited · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 7192593

    Use of recombinant parainfluenza viruses (PIVs) as vectors to protect against infection and disease caused by PIV and other human pathogens

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 7192588

    Vaccine composition and method of using the same

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 7192704

    Methods for detection and treatment of neural cancers

    The Regents of the University of California · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 7192932

    Use of immunomodulating agents

    Lauras AS · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 7192705

    Transductin-1 and applications to hereditary deafness

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 7192735

    Phosphopantetheinyl transferases and uses thereof

    The Regents of the University of California · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 7192978

    Pyrrolidinium derivatives

    Almirall Prodesfarma S.A. · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 7192914

    Prevention of atherosclerosis and undesired blood clotting by reducing von Willebrand factor

    The Regents of the University of California · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 7192940

    Ether compounds

    Esperion Therapeutics, Inc. · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 7192982

    Modulators of peroxisome proliferator activated receptors

    Ligand Pharmaceuticals Incorporated · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 7193033

    Peptide having appetite stimulating activity

    Takeda Pharmaceutical Company Limited · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 7193034

    Synthetic peptides, conjugation reagents and methods

    The Regents of the University of California · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 7193053

    Hypoxia-inducible factor 1alpha variants and methods of use

    UNITED STATES OF AMERICA, AS REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 7193072

    Compositions to identify swine genetically resistant to F18 E. coli associated diseases

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Mar 20 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 15 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 7195778

    Drug delivery system for zero order, zero order-biphasic, ascending or descending drug delivery

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Mar 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 7196205

    Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Mar 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 7195768

    Polyvalent immunogen

    The Regents of the University of California · Granted Tue Mar 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 7195876

    Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same

    Theravance, Inc. · Granted Tue Mar 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 7196119

    Development of new selective estrogen receptor modulators

    The Regents of the University of California · Granted Tue Mar 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 7195911

    Mammalian cells that have increased proliferative capacity

    The Regents of the University of Colorado · Granted Tue Mar 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 7196074

    Methods of making, using and pharmaceutical formulations comprising 7α, 11β-dimethyl-17β-hydroxyestra-4, 14-dien-3-one and 17 esters thereof

    The United States of America, as represented by the Department of Health and Human Services · Granted Tue Mar 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 7196098

    Quinuclidine derivatives and medicinal compositions containing the same

    Almirall Prodesfarma S.A. · Granted Tue Mar 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 7196184

    Double-stranded RNA (DSRNA) and method of use for inhibiting expression of the AML-1/MTG8 fusion gene

    Alnylam Europe AG · Granted Tue Mar 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 7196222

    Sertraline hydrochloride form II and methods for the preparation thereof

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Mar 27 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 22 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 7199223

    Polymer-factor VIII moiety conjugates

    Nektar Therapeutics AL, Corporation · Granted Tue Apr 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 7198788

    Anti-CD26 monoclonal antibodies as therapy for diseases associated with cells expressing CD26.

    The Board of Regents of the University of Texas System · Granted Tue Apr 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 7198949

    Compositions and methods for altering the biodistribution of biological agents

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Apr 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 7199124

    JNK inhibitor

    Takeda Pharmaceutical Company Limited · Granted Tue Apr 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 7198947

    Production of functional proteins: balance of shear stress and gravity

    The United States of America as represented by the Administrator of the National Aeronautics and Space Administration · Granted Tue Apr 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 7199157

    Use of treprostinil to improve kidney functions

    United Therapeutics Corporation · Granted Tue Apr 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 7198783

    Sensitization of neoplastic cells to radiation therapy with reovirus

    ONCOLYTICS BIOTECH INC. · Granted Tue Apr 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 7199103

    Synthetic compounds and compositions with enhanced cell binding

    The Regents of the University of California · Granted Tue Apr 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 7199127

    Purine nucleosides

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 7199102

    Orally administered peptides synergize statin activity

    The Regents of the University of California · Granted Tue Apr 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 7199114

    Triterpene quaternary salts as biologically active surfactants

    Regents of the University of Minnesota · Granted Tue Apr 03 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Mar 29 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 7201911

    Cloned genomes of infectious hepatitis C viruses and uses thereof

    UNITED STATES OF AMERICA, AS REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES · Granted Tue Apr 10 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 05 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 7202045

    Detection and treatment of cancers of the lung

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Apr 10 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 05 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 7201902

    Production of recombinant protein pap 31 for the diagnosis and prevention of Bartonella bacilliformis infection

    United States of America as represented by the Secretary of the Air Force · Granted Tue Apr 10 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 05 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 7201907

    Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 10 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 05 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 7201920

    Methods and compositions for deterring abuse of opioid containing dosage forms

    Acurx Pharmaceuticals, Inc. · Granted Tue Apr 10 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 05 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 7202040

    Method for screening compounds which change the binding properties of a protein with a ligand

    Takeda Pharmaceutical Company Limited · Granted Tue Apr 10 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 05 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 7202087

    Anticoagulant composition

    LTP Lipid Technologies Provider AB · Granted Tue Apr 10 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 05 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 7202262

    Benzoic acid or benzoate substituted 1,2,4-oxadiazole compounds and their use for the treatment of disease

    PTC THERAPEUTICS, INC. · Granted Tue Apr 10 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 05 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 7205011

    Anti-inflammatory activity of a specific turmeric extract

    Board of Regents, Acting for and on behalf of, University of Arizona · Granted Tue Apr 17 2007 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 12 2027 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

What is a patent cliff?

A patent cliff is when key pharmaceutical patents expire, opening markets to generics or biosimilars. This hub lists USPTO patents with approaching expiration dates.

Are expiration dates estimates?

Expiration dates derive from USPTO PatentsView grant dates and term estimates. Confirm with Orange Book, patent counsel, and USPTO records before investment decisions.

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