Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Patents expiring in 2045

Annual patent cliff calendar for 2045 — US pharmaceutical patents by expiration date.

Patents
1,566

Quick answer

1,566 indexed pharmaceutical patents have expiration dates in 2045. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 12428463

    Chimeric antigen receptors targeting abnormal glycobiology

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Sep 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 25 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 12428432

    Thienopyrimidine derivatives having stereo configurations and use thereof in medicine

    SUNSHINE LAKE PHARMA CO., LTD. · Granted Tue Sep 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 25 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 12428489

    Human PD-L2 antibodies and methods of use therefor

    The Board of Regents of the University of Texas System · Granted Tue Sep 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 25 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 12428487

    Complexes comprising an anti-transferrin receptor antibody linked to an oligonicleotide and method of delivering oligonucleotide to a subject

    Dyne Therapeutics, Inc. · Granted Tue Sep 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 25 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 12428480

    Anti-CD19 antibodies and multi-specific binding proteins

    Cullinan Therapeutics, Inc. · Granted Tue Sep 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 25 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 2025304535

    KAT6 Inhibitors

    BEIGENE SWITZERLAND GMBH [CH] · Granted Thu Oct 02 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Sep 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. WO 2025207959

    ANTICORPS ANTI-RÉCEPTEURS DE LA TRANSFERRINE ET LEURS UTILISATIONS

    BIOGEN MA INC [US] · Granted Thu Oct 02 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Sep 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. WO 2025207948

    CAPSIDES D'AAV POUR LE CIBLAGE DU RÉCEPTEUR DE LA TRANSFERRINE HUMAINE

    BIOGEN MA INC [US] · Granted Thu Oct 02 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Sep 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. WO 2025207932

    CAPSIDES DE VAA COMPRENANT DES DOMAINES D'ANTICORPS ANTI-TRANSFERRINE

    BIOGEN MA INC [US] · Granted Thu Oct 02 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Sep 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. WO 2025207099

    INHIBITEURS DE PPAR-DELTA POUR PRÉVENIR UNE FIBRILLATION AURICULAIRE POST-OPÉRATOIRE

    ASTELLAS PHARMA INC [JP] · Granted Thu Oct 02 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Sep 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. WO 2025202022

    INHIBITEURS DE L'INTERACTION ENTRE RAS ET SOS1 À BASE DE QUINAZOLINE, MACROCYCLIQUES ET ANTICANCÉREUX

    BAYER AG [DE] · Granted Thu Oct 02 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Sep 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. WO 2025201453

    COMPOSÉS MACROCYCLIQUES UTILISÉS EN TANT QU'INHIBITEURS DE RAS

    BEIGENE SUZHOU CO LTD [CN] · Granted Thu Oct 02 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Sep 27 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. WO 2025211975

    AGONISTES DU RÉCEPTEUR DE L'OREXINE

    BIAL PORTELA & CA SA [PT] · Granted Thu Oct 09 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 04 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. WO 2025210141

    SYSTÈME D'ADMINISTRATION UTILE POUR L'ADMINISTRATION TOPIQUE D'ARN

    BOEHRINGER INGELHEIM VETMEDICA GMBH [DE] · Granted Thu Oct 09 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 04 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. WO 2025214466

    CONJUGUÉS DE PYRROLOBENZODIAZÉPINE CIBLÉS

    BEIGENE GUANGZHOU BIOLOGICS MFG CO LTD [CN] · Granted Thu Oct 16 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 11 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. WO 2025221754

    UPADACITINIB DESTINÉ À ÊTRE UTILISÉ DANS LE TRAITEMENT DE L'ARTÉRITE À CELLULES GÉANTES

    ABBVIE INC [US] · Granted Thu Oct 23 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 18 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. WO 2025218772

    FORMES SOLIDES COMPRENANT UN AGENT DE DÉGRADATION DE TYROSINE KINASE DE BRUTON ET LEURS UTILISATIONS

    BEIGENE SUZHOU CO LTD [CN] · Granted Thu Oct 23 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 18 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 2025325692

    METHODS OF TREATMENT USING ANTI-SEZ6 ANTIBODY DRUG CONJUGATES

    ABBVIE INC [US] · Granted Thu Oct 23 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 18 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. WO 2025219169

    PRÉPARATIONS STABLES EN CAPSULES SOUPLES AVEC REMPLISSAGE LIQUIDE POUR PRINCIPES ACTIFS SENSIBLES À L'HUMIDITÉ

    BAYER CONSUMER CARE AG [CH] · Granted Thu Oct 23 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 18 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. EP 4640274

    LPAR1-INHIBITOREN

    ABBVIE INC [US] · Granted Wed Oct 29 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Oct 24 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 2025333381

    SOLID STATE FORMS

    AMGEN INC [US] · Granted Thu Oct 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 25 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. WO 2025224069

    CO-CRISTAUX DE FINÉRÉNONE, DE PECAVAPTAN ET D'INHIBITEURS DE SGLT2

    BAYER AG [DE] · Granted Thu Oct 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 25 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 2025333394

    Tiparp Inhibitor Compounds

    ABBVIE INC [US] · Granted Thu Oct 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 25 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. WO 2025230860

    FORMES SOLIDES DE COMPOSÉS MACROCYCLIQUES ET LEURS UTILISATIONS

    AMGEN INC [US] · Granted Thu Nov 06 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 01 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. WO 2025230878

    COMPOSÉS MACROCYCLIQUES UTILISÉS EN TANT QUE MODULATEURS DE KRAS ET LEURS UTILISATIONS

    AMGEN INC [US] · Granted Thu Nov 06 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 01 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. WO 2025230528

    MÉTHODES DE TRAITEMENT DE LA SCLÉROSE LATÉRALE AMYOTROPHIQUE

    CALICO LIFE SCIENCES LLC [US] · Granted Thu Nov 06 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 01 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. WO 2025230862

    COMPOSÉS AMINÉS MACROCYCLIQUES UTILISÉS EN TANT QUE MODULATEURS DE KRAS ET LEURS UTILISATIONS

    AMGEN INC [US] · Granted Thu Nov 06 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 01 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. WO 2025233516

    MÉTHODE D'AUGMENTATION DU TEMPS JUSQU'À LA DEUXIÈME PROGRESSION ET DU TEMPS JUSQU'À LA PREMIÈRE CHIMIOTHÉRAPIE SUIVANTE

    ASTRAZENECA AB [SE] · Granted Thu Nov 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. AU 2024268154

    NOVEL CARBOXAMIDE DERIVATIVES

    ANGELINI PHARMA S P A [IT] · Granted Thu Nov 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. WO 2025232885

    PROCÉDÉ DE PRÉPARATION D'UN AGENT DE DÉGRADATION DE LA TYROSINE KINASE DE BRUTON

    BEIGENE SUZHOU CO LTD [CN] · Granted Thu Nov 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. WO 2025233501

    CONJUGUÉS COMPRENANT UN INHIBITEUR DE TOPOISOMÉRASE I

    ASTRAZENECA AB [SE] · Granted Thu Nov 13 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 08 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. WO 2025238221

    VECTEURS VIRAUX CODANT POUR DES NANOPARTICULES DE PROTÉINE À PRÉSENTATION D'ANTIGÈNES MULTIPLES

    BAVARIAN NORDIC AS [DK] · Granted Thu Nov 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. WO 2025237912

    INHIBITEURS DE KEAP1 DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE LA BRONCHECTASIE

    ASTRAZENECA AB [SE] · Granted Thu Nov 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. WO 2025238159

    POLYTHÉRAPIE COMPRENANT DE L'AZD0780 ET DE L'ÉZÉTIMIBE

    ASTRAZENECA AB [SE] · Granted Thu Nov 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. WO 2025238218

    VECTEURS VIRAUX CODANT POUR DES NANOPARTICULES DE PROTÉINE D'AFFICHAGE D'ANTIGÈNE

    BAVARIAN NORDIC AS [DK] · Granted Thu Nov 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. WO 2025238219

    VIRUS MODIFIÉ DE LA VACCINE ANKARA (MVA) CODANT POUR DES NANOPARTICULES PROTÉIQUES PRÉSENTANT DES ANTIGÈNES

    BAVARIAN NORDIC AS [DK] · Granted Thu Nov 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. WO 2025238220

    ACIDES NUCLÉIQUES POUR LA VACCINATION CODANT POUR DES NANOPARTICULES DE PROTÉINE DE PRÉSENTATION DES ANTIGÈNES

    BAVARIAN NORDIC AS [DK] · Granted Thu Nov 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. WO 2025242583

    NOUVELLE FORMULATION COMPRENANT DE L'ÉLINZANÉTANT DANS UNE DISPERSION SOLIDE

    BAYER CONSUMER CARE AG [CH] · Granted Thu Nov 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. WO 2025242689

    MÉTHODES DE TRAITEMENT D'UNE MALADIE RÉNALE MÉDIÉE PAR APOL1

    ASTRAZENECA AB [SE] · Granted Thu Nov 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. WO 2025242585

    FORMES CRISTALLINES DE SELS D'ÉLINZANÉTANT ET COMPOSITIONS CONTENANT DES SELS D'ÉLINZANÉTANT

    BAYER CONSUMER CARE AG [CH] · Granted Thu Nov 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. WO 2025242584

    FORMULATION DE CAPSULE DE GÉLATINE MOLLE STABLE POUR ÉLINZANÉTANT

    BAYER CONSUMER CARE AG [CH] · Granted Thu Nov 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. MX 2025012909

    METHOD FOR INDUCING AN IMMUNE RESPONSE

    BOEHRINGER INGELHEIM VETMEDICA GMBH [DE] · Granted Mon Dec 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Sun Nov 26 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. WO 2025247981

    DOSAGE PHARMACEUTIQUE DÉRIVÉ DE FUROINDAZOLE

    BAYER AG [DE] · Granted Thu Dec 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. AU 2024276234

    METHODS OF TREATMENT USING ANTI-C-MET ANTIBODY DRUG CONJUGATES

    ABBVIE MFG MANAGEMENT UNLIMITED COMPANY [IE] · Granted Thu Dec 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. WO 2025250831

    CONJUGUÉS ANTICORPS-MÉDICAMENT IMMUNOSTIMULANTS À BASE D'AGONISTE DE STING

    ASTELLAS PHARMA INC [JP] · Granted Thu Dec 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. WO 2025250569

    TRAITEMENTS DU CANCER UTILISANT DES INHIBITEURS DE PRMT5 MTA-COOPÉRATIFS ET DES INHIBITEURS DE MAT2A

    AMGEN INC [US] · Granted Thu Dec 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. WO 2025248119

    DÉRIVÉS DE 6-(CYCLO)ALCOXYPURINE UTILES EN TANT QU'INHIBITEURS DE POLQ

    ASTRAZENECA AB [SE] · Granted Thu Dec 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. WO 2025248117

    DÉRIVÉS DE 6-AMINOPURINE UTILES EN TANT QU'INHIBITEURS DE POLQ

    ASTRAZENECA AB [SE] · Granted Thu Dec 04 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 29 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2045?

1,566 published patents in our USPTO index have expiration dates falling in calendar year 2045.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.