Wednesday, June 10, 2026
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Intelligence · Patents

Patents expiring in 2045

Annual patent cliff calendar for 2045 — US pharmaceutical patents by expiration date.

Patents
1,566

Quick answer

1,566 indexed pharmaceutical patents have expiration dates in 2045. Browse by soonest expiry with links to assignee companies and related drugs.

  1. WO 2025114603

    COMBINAISONS PHARMACEUTIQUES DESTINÉES À ÊTRE UTILISÉES DANS LE TRAITEMENT D'INFECTIONS FONGIQUES

    BASILEA PHARMACEUTICA INT AG ALLSCHWIL [CH] · Granted Thu Jun 05 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed May 31 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. WO 2025114529

    ANTICORPS MULTISPÉCIFIQUES RECONNAISSANT L'ALBUMINE SÉRIQUE HUMAINE, TCR ET FRACTION RECONNAISSANT L'ANTIGÈNE TUMORAL

    ABLYNX NV [BE] · Granted Thu Jun 05 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed May 31 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 12325747

    Human PD-L1 antibodies and methods of use therefor

    The Board of Regents of the University of Texas System · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 12325752

    Immunoglobulin proteins that bind to NPR1 agonists

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 12325733

    Binding domain

    AUTOLUS LIMITED · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 12325708

    Adenosine 2 receptor antagonists

    Nektar Therapeutics · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 12325732

    Pro-insulin aspart structure and method for preparing insulin aspart

    AMPHASTAR NANJING PHARMACEUTICALS INC · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 12325854

    Crispr-CPF1-related methods, compositions and components for cancer immunotherapy

    Editas Medicine, Inc. · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 12325753

    Method of using an anti-transferrin receptor antibody to deliver an oligonucleotide to a subject having facioscapulohumeral muscular dystrophy

    Dyne Therapeutics, Inc. · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 12324812

    Glucopyranosyl derivatives and their uses

    SUNSHINE LAKE PHARMA CO., LTD. · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 12325755

    Macropinocytosing human anti-CD46 antibodies and targeted cancer therapeutics

    The Regents of the University of California · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 12324802

    Modulators of cystic fibrosis transmembrane conductance regulator

    Vertex Pharmaceuticals Incorporated · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 12326492

    Systems and methods of detecting interstitial cystitis

    LIPELLA PHARMACEUTICALS, INC. · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 12325750

    Anti-Dectin-2 antibodies and methods of using

    Bolt Biotherapeutics, Inc. · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 12325715

    Fluorous metal chelates compositions

    The Regents of the University of California · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 12324837

    ROR1-specific antigen binding molecules

    ALMAC DISCOVERY LIMITED · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 12325703

    Fused ring compound as FGFR and VEGFR dual inhibitor

    CGeneTech (Suzhou, China) CO., Ltd. · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 12325705

    Small molecules for the treatment of primary cancer and cancer metastasis

    The Board of Regents of the University of Texas System · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 12324798

    Leonurine nanocomposite hydrogel and preparation methods and applications thereof

    WEST CHINA HOSPITAL, SICHUAN UNIVERSITY · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 12325699

    Antibacterial compounds

    BLACKSMITH MEDICINES, INC. · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 12325688

    Gingerenone A prodrugs as sensotherapeutics and methods of use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 12325691

    Compounds and methods for treating cancer, neurological disorders, ethanol withdrawal, anxiety, depression, and neuropathic pain

    The Board of Regents of the University of Texas System · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 12325710

    Substituted 1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles for treating brain disorders

    The Regents of the University of California · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 12325711

    3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-[1,2,4]triazolo[4,3-α]pyrazine as an ion channel modulator

    PRAXIS PRECISION MEDICINES, INC. · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 12324843

    Compositions and methods for delivery of biomacromolecule agents

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 12324828

    Conjugates of a factor VIII moiety having an oxime-containing linkage

    Nektar Therapeutics · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 12324787

    Kits for preparing and delivering purified corticotropin

    ANI Pharmaceuticals, Inc. · Granted Tue Jun 10 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 05 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. EP 4567715

    ERZEUGUNG SYNTHETISCHER DARSTELLUNGEN

    BAYER AG [DE] · Granted Wed Jun 11 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Jun 06 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. EP 4567716

    ERZEUGUNG SYNTHETISCHER DARSTELLUNGEN

    BAYER AG [DE] · Granted Wed Jun 11 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Jun 06 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. AR 132316

    TRATAMIENTO COMBINADO CON CLASCOTERONA Y MINOXIDIL

    CASSIOPEA S P A [IT] · Granted Wed Jun 11 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Jun 06 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. WO 2025120867

    POLYTHÉRAPIE IMPLIQUANT DES AGENTS DE LIAISON BISPÉCIFIQUES SE LIANT À CLDN18.2 ET CD3 ET ANTICORPS ANTI-VEGFR2

    ASTELLAS PHARMA INC [JP] · Granted Thu Jun 12 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jun 07 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. WO 2025121445

    POLYTHÉRAPIE IMPLIQUANT DES AGENTS DE LIAISON BISPÉCIFIQUES SE LIANT À CLDN18.2 ET CD3 ET AGENTS STABILISANT OU AUGMENTANT L'EXPRESSION DE CLDN18.2

    ASTELLAS PHARMA INC [JP] · Granted Thu Jun 12 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jun 07 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. WO 2025120866

    POLYTHÉRAPIE IMPLIQUANT DES AGENTS DE LIAISON BISPÉCIFIQUES SE LIANT À CLDN18.2 ET CD3 ET AGENTS STABILISANT OU AUGMENTANT L'EXPRESSION DE CLDN18.2

    ASTELLAS PHARMA INC [JP] · Granted Thu Jun 12 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jun 07 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. TW 202523278

    Antibody drug conjugate platforms

    BEIGENE LTD [KY] · Granted Mon Jun 16 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Sun Jun 11 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 12331279

    Systems for producing cellular immunotherapeutics and methods of use thereof

    Northwestern University · Granted Tue Jun 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 12332255

    Methods for monitoring treatment of chronic liver disease

    The Regents of the University of Colorado · Granted Tue Jun 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 12331328

    CRISPR/Cas9-mediated exon-skipping approach for USH2A-associated usher syndrome

    Editas Medicine, Inc. · Granted Tue Jun 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 12329739

    Isoflavonoid compounds and methods for the treatment of cancer

    Aardvark Therapeutics, Inc. · Granted Tue Jun 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 12329756

    Regulation of eIF4E activity for migraine therapy

    The Board of Regents of the University of Texas System · Granted Tue Jun 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 12329816

    Immunotherapy with metabolic enzyme expression

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Jun 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 12329824

    Muscle targeting complexes and uses thereof for treating dystrophinopathies

    Dyne Therapeutics, Inc. · Granted Tue Jun 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 12331099

    VEGF antagonist formulations suitable for intravitreal administration

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 12331127

    Therapeutic uses of anti-GITR antibodies

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jun 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 12331307

    Modified immunization vectors

    ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Jun 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 12329457

    Hyperspectral imaging for early detection of Alzheimer's disease

    Regents of the University of Minnesota · Granted Tue Jun 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 12329776

    Treatment methods for ALS patients

    The Regents of the University of California · Granted Tue Jun 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 12331079

    Oncolytic virus platform to treat cancers with myxoma virus

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Jun 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 12331026

    Sulfonamido derivatives as cyclin-dependent kinase 2 inhibitors

    NIKANG THERAPEUTICS, INC. · Granted Tue Jun 17 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 12 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2045?

1,566 published patents in our USPTO index have expiration dates falling in calendar year 2045.

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