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Intelligence · Patents

Patents expiring in 2045

Annual patent cliff calendar for 2045 — US pharmaceutical patents by expiration date.

Patents
1,566

Quick answer

1,566 indexed pharmaceutical patents have expiration dates in 2045. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 12304964

    CD38 modulating antibody

    BLACK BELT THERAPEUTICS LIMITED · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 12304969

    Factor XI A2 domain-binding antibodies and methods of use thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 12303594

    Antimicrobial and anti-inflammatory compositions

    The Board of Regents of the University of Texas System · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 12304940

    HLA class II-restricted t cell receptors against mutated RAS

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 12304942

    Cell comprising a chimeric antigen receptor or a transgenic T-cell receptor and comprising a chimeric TNF receptor

    AUTOLUS LIMITED · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 12303479

    Chloride intracellular channel 1 for regulation of food intake

    The Regents of the University of California · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 12304912

    Fused bicyclic RAF inhibitors and methods for use thereof

    Jazz Pharmaceuticals Ireland Limited · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 12304968

    T-cells expressing anti-LIV1 chimeric antigen receptor

    CRISPR THERAPEUTICS AG · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 12304907

    Compounds and methods of use

    Tango Therapeutics, Inc. · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 12303724

    Non-adult human dosing of anti-CD30 antibody-drug conjugates for treatment of hematological or lymphoid cancer

    Takeda Pharmaceutical Company Limited · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 12303602

    Compositions, methods and uses for thermally stable multi-targeted antigens

    The Regents of the University of Colorado, a Body Corporate · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 12303551

    Cellular immunotherapy compositions and uses thereof

    Cero Therapeutics Holdings, Inc. · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 12304901

    Selective ligands for tau aggregates

    Sentonix, Inc. · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 12303481

    Levodopa dosing regimen

    AMNEAL PHARMACEUTICALS LLC · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 12304900

    Islet cell manufacturing compositions and methods of use

    Vertex Pharmaceuticals Incorporated · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 12303618

    Oxygen-generating cryogels

    Northwestern University · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 12304898

    Quinolyl-containing compound and pharmaceutical composition, and use thereof

    PrimeGene (Beijing) Co., Ltd. · Granted Tue May 20 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 15 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. WO 2025106633

    INHIBITEURS DE TYK2

    BIOGEN MA INC [US] · Granted Thu May 22 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed May 17 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 12312411

    Anti-CD38 binding domains

    Takeda Pharmaceutical Company Limited · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 12311054

    Compositions and methods of using propylene sulfide-based polymers for treatment of Chagas disease

    Northwestern University · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 12312348

    RET inhibitors, pharmaceutical compositions and uses thereof

    SUNSHINE LAKE PHARMA CO., LTD. · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 12312375

    Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use

    Compass Pathfinder Limited · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 12310943

    Compositions and methods for improving mitochondrial function and treating neurodegenerative diseases and cognitive disorders

    Amazentis SA · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 12311029

    Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein

    Northwestern University · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 12312377

    Biconjugatable labels and methods of use

    Quantum-Si Incorporated · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 12312345

    Fluoroalkyl-oxadiazoles and uses thereof

    Tenaya Therapeutics, Inc. · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 12312339

    Polo like kinase 4 inhibitors

    ORIC PHARMACEUTICALS, INC. · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 12310986

    Compositions and methods for the treatment of cancer cells by induction of cytotoxic oxidative stress

    The Board of Regents of the University of Texas System · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 12310944

    Selective butyrylcholinesterase inhibitor or pharmaceutically acceptable salt thereof, preparation method and use thereof

    CHINA PHARMACEUTICAL UNIVERSITY · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 12312391

    Anti-mutated KRAS T cell receptors

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 12310929

    Use of rasagiline for the treatment of restless legs syndrome

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 12312334

    Quinoxaline compounds and uses thereof

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 12311017

    Identification of immunologically protective neo-epitopes for the treatment of cancers

    UNIVERSITY OF CONNECTICUT · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 12310996

    Methods for enhancing immune checkpoint blockade therapy by modulating the microbiome

    The Board of Regents of the University of Texas System · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 12310988

    BCMA chimeric antigen receptors and uses thereof

    The Board of Regents of the University of Texas System · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 12311026

    Therapeutic uses for sodium thiosulfate formulations

    Fennec Pharmaceuticals, Inc. · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 12311059

    Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes

    Quince Therapeutics S.p.A. · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 12311016

    Biomarkers and immunogenic compositions for filarial parasites

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 12311169

    Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion

    The Regents of the University of California · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 12310992

    Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells

    United Therapeutics Corporation · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 12312616

    CRISPR-Cas effector polypeptides and methods of use thereof

    The Regents of the University of California · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 12311030

    Antibody-sting agonist conjugates and their use in immunotherapy

    The Board of Regents of the University of Texas System · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 12311053

    Nanotube-vesicle compositions and uses thereof

    The Regents of the University of California · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 12310968

    Chiral diaryl macrocycles and uses thereof

    TURNING POINT THERAPEUTICS, INC. · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 12310954

    Salivary gland regeneration

    The Regents of the University of California · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 12310956

    Topical roflumilast formulation having improved delivery and plasma half-life

    ARCUTIS BIOTHERAPEUTICS, INC. · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 12310934

    Methods of treatment of spontaneous preterm birth

    The Regents of the University of California · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 12310965

    Treatment of cancer utilizing an identified adenosine fingerprint

    Arcus Biosciences, Inc. · Granted Tue May 27 2025 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 22 2045 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2045?

1,566 published patents in our USPTO index have expiration dates falling in calendar year 2045.

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