Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2042

Annual patent cliff calendar for 2042 — US pharmaceutical patents by expiration date.

Patents
1,738

Quick answer

1,738 indexed pharmaceutical patents have expiration dates in 2042. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11485743

    Protein degraders and uses thereof

    Kymera Therapeutics, Inc. · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11485709

    Cannabinoid receptor mediating compounds

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11485734

    Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2C (5-HT2C)

    Northwestern University · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11484603

    Methods, systems, and compositions for inhibiting virulence of A/E family pathogens

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11485732

    Compounds and uses thereof

    FOGHORN THERAPEUTICS INC. · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11484591

    Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin A analogues or metabolites, and estradiol metabolites

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11484545

    Compounds and methods for treating neurological and cardiovascular conditions

    The Board of Regents of the University of Texas System · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11484525

    Mu opioid receptor modulators

    The Regents of the University of California · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11485739

    Compounds useful as inhibitors of ATR kinase

    Vertex Pharmaceuticals Incorporated · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11484523

    Compositions for prevention and treatment of symptoms associated with alcohol consumption

    Purple Biosciences LLC · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11484477

    Dental adhesive material kit

    KURARAY NORITAKE DENTAL INC. · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11484602

    Bicyclic peptide ligands specific for EphA2

    BicycleTx Limited · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11484521

    Antidotes to cyanide poisoning

    The Regents of the University of California · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11484531

    Methods for treating chronic obstructive pulmonary disease

    Theravance Biopharma R&D IP, LLC · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11484573

    Activin receptor type IIa variants and methods of use thereof

    Keros Therapeutics, Inc. · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11485738

    Substituted imidazo[1,2-c]pyrimidines as PRC2 inhibitors

    Mirati Therapeutics, Inc. · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11484511

    Pharmaceutical composition comprising THA as effective ingredient for treatment of prostate cancer

    KOREA UNITED PHARM. INC. · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11485788

    Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an IL-4R inhibitor

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11485976

    Bacterial minicells for delivering nucleic acid adjuvants and methods of using the same

    EnGeneIC Molecular Delivery Pty Ltd · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11485961

    Compositions and methods for treating celiac sprue disease

    The Regents of the University of California · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11485793

    Anti-MUC16 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind MUC16 and CD3, and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11485760

    Inhibitors of CRISPR-Cas9

    The Regents of the University of California · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11485958

    HSD17B13 variants and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11484581

    Method to create personalized canine cancer vaccines

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11486802

    Methods and devices for high throughput purification

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Nov 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. WO 2022229817

    VACCINS COMPRENANT DES PARTICULES PSEUDO-VIRALES PRÉSENTANT DES ANTIGÈNES DU SARS-COV-2 ET LEURS MÉTHODES D'UTILISATION

    BAVARIAN NORDIC AS [DK] · Granted Thu Nov 03 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 2022348923

    CA-IX APTAMERS AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF

    BRACCO IMAGING SPA [IT] · Granted Thu Nov 03 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. IT 202100010802

    FORMULAZIONE SOLIDA MUCOADESIVA COMPRENDENTE PROBIOTICI PER USO NELLA PREVENZIONE E NEL TRATTAMENTO DI DISBIOSI ORALE.

    ALFASIGMA SPA [IT] · Granted Thu Nov 03 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 29 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11492368

    Pharmaceutical targeting of a mammalian cyclic di-nucleotide signaling pathway

    The Board of Regents of the University of Texas System · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11490643

    Lactobacillus casei for treating obesity and associated metabolic disorders

    PrecisionBiotics Group Limited · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11491133

    Heteroaryl-isochroman compounds and uses thereof

    PGI Drug Discovery LLC · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11491190

    Visco-supplement compositions, and methods of use thereof

    Prime Merger Sub, LLC · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11491215

    Antigenic combinations against Francisella bacteria and related nanolipoprotein particles, compositions, methods and systems

    The Regents of the University of New Mexico · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11491193

    Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them

    Finch Therapeutics Holdings LLC · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11492650

    Production of seleno-biologics in genomically recoded organisms

    The Board of Regents of the University of Texas System · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11492617

    Compositions and methods for modulation of protein aggregation

    Ionis Pharmaceuticals, Inc. · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11492392

    Polynucleotides encoding anti-C5 antibodies

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11492350

    Compounds and methods of use

    Tango Therapeutics, Inc. · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11492351

    MTA-cooperative PRMT5 inhibitors

    Mirati Therapeutics, Inc. · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11492349

    IRAK inhibitors and method for making and using

    Rigel Pharmaceuticals, Inc. · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11491222

    Method of treating lower back pain

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11491212

    Subcutaneous administration of modified factor IX polypeptides and treatment of hemophilia B

    Catalyst Biosciences, Inc. · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11491125

    Baclofen formulations and methods of minimizing patient exposure to metabolite variations

    AMNEAL PHARMACEUTICALS LLC · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11491187

    Methods of conditioning patients for T cell therapy

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11491145

    Combination therapies comprising targeted therapeutics

    Madrigal Pharmaceuticals, Inc. · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11491115

    Nanoparticles containing extracellular matrix for drug delivery

    The Board of Regents of the University of Texas System · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11491111

    Thermostable vaccine compositions and methods of preparing same

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11491123

    Pharmaceutical compositions with antiflaviviral activity

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 03 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2042?

1,738 published patents in our USPTO index have expiration dates falling in calendar year 2042.