Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Patents expiring in 2042

Annual patent cliff calendar for 2042 — US pharmaceutical patents by expiration date.

Patents
1,738

Quick answer

1,738 indexed pharmaceutical patents have expiration dates in 2042. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11389497

    Pharmaceutical composition for treating cancer

    Prime Bio, Inc. · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 11389386

    Photochemically stable, non-leaching, bridged polysilsesquioxane based sunscreens

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 11389407

    Cochleates and methods of using the same to enhance tissue penetration of pharmacologically active agent

    MATINAS BIOPHARMA NANOTECHNOLOGIES, INC. · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 11389396

    Tumescent antibiotic injection for treatment of chronic skin and soft tissue infections

    The Regents of the University of California · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 11390683

    Anti-mesothelin polypeptides and proteins

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 11390848

    Materials and methods for modifying the activity of T cells

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 11390884

    Optimized CRISPR/cas9 systems and methods for gene editing in stem cells

    Editas Medicine, Inc. · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 11389400

    Aerosilization of stem cells or stem cell derivatives for pulmonary delivery

    The Government of the United States, as represented by the Secretary of the Army · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 11390667

    Compositions and methods for the treatment of neuromyelitis optica

    The Regents of the University of California · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 11390631

    Benzodiazepine derivatives as RSV inhibitors

    Enanta Pharmaceuticals, Inc. · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 11389663

    Laser assisted wound healing protocol and system

    BIOREGENTECH, INC. · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 11389544

    Formation of functionalized cancer targeting nanoparticles by supramolecular co-assembly

    TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 11389485

    Genetically engineered hematopoietic stem cells and uses thereof

    Vor Biopharma Inc. · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 11389480

    Human monoclonal antibody targeting TNFR2 for cancer immunotherapy

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 11389449

    Treatment of metabolic syndrome with an sGC stimulator

    Cyclerion Therapeutics, Inc. · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 11389433

    BRD4 inhibitor treatment of IgE-mediated diseases

    The Board of Regents of the University of Texas System · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 11389432

    Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent

    Corcept Therapeutics Incorporated · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 11390861

    CRISPR/cas-related methods and compositions for treating herpes simplex virus

    Editas Medicine, Inc. · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 11390687

    Bispecific antibodies against plasma kallikrein and Factor XII

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 11390682

    Methods of intravenouisly delivering anti-transferrin antibody/oligonucleotide complexes to subjects having muscular dystrophy

    Dyne Therapeutics, Inc. · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 11390634

    Fused heterocyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 11390646

    Structure-based peptide inhibitors of α-synuclein aggregation

    The Regents of the University of California · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 11390605

    Substituted pyrimidine compounds as multifunctional radical quenchers and their uses

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 11390588

    2-substituted amino-naphth (1,2-d) imidazol-5-one compounds of pharmaceutically acceptable salts thereof

    PTC THERAPEUTICS, INC. · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 11390606

    Pyridazinone compounds and uses thereof

    EDGEWISE THERAPEUTICS, INC. · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 11390603

    Crystalline forms of a biphenyl compound

    Theravance Biopharma R&D IP, LLC · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 11390600

    Crystalline forms of C21H22Cl2N4O2

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 11396506

    Amino acid compounds with unbranched linkers and methods of use

    Pliant Therapeutics, Inc. · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 11395850

    RSV vaccines and methods of production and use thereof

    The Board of Regents for Oklahoma State University · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 11395855

    Exon skipping oligomer conjugates for muscular dystrophy

    Sarepta Therapeutics, Inc. · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 11396540

    Methods for making recombinant proteins

    Coherus BioSciences, Inc. · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 11396544

    Bispecific anti-CD28 × anti-CD22 antibodies and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 11397184

    Selection of patients for combination therapy

    Syndax Pharmaceuticals, Inc. · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 11397188

    Method of detecting an APP Alzheimer's disease marker peptide in patients with Alzheimer's disease

    The Board of Regents of the University of Texas System · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 11395854

    Trialkyl cationic lipids and methods of use thereof

    ARBUTUS BIOPHARMA CORPORATION · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 11396495

    Amine compound for inhibiting SSAO/VAP-1 and use thereof

    SUNSHINE LAKE PHARMA CO., LTD. · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 11395848

    Methods and compositions for treating diabetes

    Oramed Ltd. · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 11395822

    Methods for treating Huntington's disease

    PTC THERAPEUTICS, INC. · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 11396530

    Bicyclic peptide ligands and uses thereof

    BicycleTx Limited · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 11395817

    Methods and compositions for treatment of epileptic disorders

    OVID THERAPEUTICS INC. · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 11396647

    Human methylthioadenosine/adenosine depleting enzyme variants for cancer therapy

    The Board of Regents of the University of Texas System · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 11396571

    Polymers including galactose based blocks and uses thereof

    Regents of the University of Minnesota · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 11395838

    Methods for enhancing immune checkpoint blockade therapy by modulating the microbiome

    The Board of Regents of the University of Texas System · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 11396654

    Neutral nanotransporters

    Phio Pharmaceuticals Corp. · Granted Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. IT 202100001169

    GEL MUCOADESIVO BUCCALE CONTENENTE PROBIOTICI PER USO NELLA PREVENZIONE E NEL TRATTAMENTO DELLE MALATTIE PARODONTALI.

    ALFASIGMA SPA [IT] · Granted Wed Jul 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Jul 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. EP 4031157

    BAKTERIENSTÄMME, IHRE ZUSAMMENSETZUNGEN UND IHRE VERWENDUNG ZUR BEHANDLUNG GASTROINTESTINALER ERKRANKUNGEN

    SOFAR SPA [IT] · Granted Wed Jul 27 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Jul 22 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. WO 2022158991

    TRAITEMENT DE LA DOULEUR ASSOCIÉE À LA MALADIE DE PARKINSON AVEC DE L'OPICAPONE EN COMBINAISON AVEC LA LÉVODOPA

    BIAL PORTELA & CA SA [PT] · Granted Thu Jul 28 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jul 23 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 11400143

    Compositions and methods for treatment of homocystinuria

    The Regents of the University of Colorado · Granted Tue Aug 02 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 28 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2042?

1,738 published patents in our USPTO index have expiration dates falling in calendar year 2042.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.