Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2042

Annual patent cliff calendar for 2042 — US pharmaceutical patents by expiration date.

Patents
1,738

Quick answer

1,738 indexed pharmaceutical patents have expiration dates in 2042. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11224584

    Sleep apnea treatment

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Jan 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 13 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11229700

    Trispecific molecule combining specific tumor targeting and local immune checkpoint inhibition

    Ludwig-Maximilians-Universitat Munchen · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11230545

    Heterocyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11229684

    Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

    Rani Therapeutics, LLC · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11230592

    DNA antibody constructs for use against middle east respiratory syndrome coronavirus

    Inovio Pharmaceuticals, Inc. · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11230542

    Inhibitors of integrated stress response pathway

    PRAXIS BIOTECH LLC · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11230587

    Ligands of B7H receptor in the treatment of osteopenia and osteoporosis

    UNIVERSITÀ DEGLI STUDI DEL PIEMONTE ORIENTALE “AMEDEO AVOGADRO” · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11229687

    TPP-1 formulations and methods for treating CLN2 disease

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11229681

    Dominant-negative FGF2 antagonists

    The Regents of the University of California · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11230607

    CD47 targeted therapies for the treatment of infectious disease

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11230712

    Compounds and methods for reducing SNCA expression

    Ionis Pharmaceuticals, Inc. · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11230537

    Polymorphs of n-[(3-fluoro-4-methoxypyridin-2-yl)methyl]-3-(methoxymethyl)-1-({4-[2-oxopyridin-1-yl)methyl]phenyl} methyl)pyrazole-4-carboxamide as iallikrein inhibitors

    KalVista Pharmaceuticals Limited · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11229609

    Compositions and methods for organ specific delivery of nucleic acids

    The Board of Regents of the University of Texas System · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11229630

    Tetrahydro-1H-pyrido [3,4-b]indole anti-estrogenic drugs

    Olema Pharmaceuticals, Inc. · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11230554

    Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds

    Rigel Pharmaceuticals, Inc. · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11230569

    Antiplasmodial compounds

    The Board of Regents of the University of Oklahoma · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11230568

    Melanocortin 1 receptor ligands and methods of use

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11229647

    Methods for treating cholestasis

    MIRUM PHARMACEUTICALS, INC. · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. LT 3544598

    CANNABINOIDS FOR PROPHYLACTIC TREATMENT OF INVOLUNTARY WEIGHT LOSS

    AOP ORPHAN PHARMACEUTICALS GMBH [AT] · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11229702

    High concentration formulations of adalimumab

    Coherus BioSciences, Inc. · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11230565

    Synthesis of backbone modified morpholino oligonucleotides and chimeras using phosphoramidite chemistry

    The Regents of the University of Colorado · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11229599

    Implant compositions for the unidirectional delivery of therapeutic compounds to the brain

    The Board of Regents of the University of Texas System · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11230591

    CMV neutralizing antigen binding proteins

    The Board of Regents of the University of Texas System · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11230536

    Crystalline (2S,4R)-5-(5′-chloro-2′-fluoro-[1,1′-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof

    Theravance Biopharma R&D IP, LLC · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11230544

    Substituted 1,3,4-thiadiazoles as GLS1 inhibitors

    Medshine Discovery Inc. · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11229600

    Compositions and methods for selective GI tract delivery

    VITAL BEVERAGES GLOBAL INC. · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11229606

    Extended release compositions comprising pyridostigmine

    Amneal Complex Products Research LLC · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11230535

    CFTR regulators and methods of use thereof

    The Regents of the University of California · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11229636

    Substituted tetrahydroquinolinone compounds as ROR gamma modulators

    Aurigene Discovery Technologies Limited · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11230590

    Hyperimmunized egg product for treatment of necrotic enteritis in poultry

    United States of America as represented by the Secretary of the Air Force · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11230596

    Methods for treatment of cancer comprising TIGIT-binding agents

    MEREO BIOPHARMA 5, INC. · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11229663

    Serum amyloid P component (APCS) iRNA compositions and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11229679

    Compositions for treating heart disease by inhibiting the action of mAKAPβ

    Anchored RSK3 Inhibitors, LLC · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11230549

    Quinolino-pyrrolidin-2-one derivative and application thereof

    Medshine Discovery Inc. · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11230530

    Human plasma kallikrein inhibitors

    BioCryst Pharmaceuticals, Inc. · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11230541

    Heterocyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Jan 25 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 20 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. AR 119975

    MÉTODOS PARA RADIOMARCAR ANTAGONISTAS DE GRPR Y SUS KITS

    ADVANCED ACCELERATOR APPLICATIONS ITALY SRL [IT] · Granted Wed Jan 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Jan 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. AR 120033

    ANTAGONISTA RADIOMARCADO DE GRPR PARA USO COMO AGENTE TERAGNÓSTICO

    ADVANCED ACCELERATOR APPLICATIONS ITALY SRL [IT] · Granted Wed Jan 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Tue Jan 21 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11234953

    Ketone bodies to protect tissues from damage by ionizing radiation

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Feb 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11234976

    Methods of using pyruvate kinase activators

    Agios Pharmaceuticals, Inc. · Granted Tue Feb 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11234418

    Genetically modified cells, tissues, and organs for treating disease

    Regents of the University of Minnesota · Granted Tue Feb 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11234960

    Compositions and methods for improving mitochondrial function and treating neurodegenerative diseases and cognitive disorders

    Amazentis SA · Granted Tue Feb 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11236315

    Thermophile peptidoglycan hydrolase fusion proteins and uses thereof

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Feb 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11236171

    Human monoclonal antibodies specific for FLT3 and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Feb 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11236173

    CD38 antibody

    BLACK BELT THERAPEUTICS LIMITED · Granted Tue Feb 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11234939

    Dosage forms comprising a plasma kallikrein inhibitor

    KalVista Pharmaceuticals Limited · Granted Tue Feb 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11236175

    T cell modifying compounds and uses thereof

    Sangamo Therapeutics, Inc. · Granted Tue Feb 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11236035

    Salts of treprostinil

    United Therapeutics Corporation · Granted Tue Feb 01 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jan 27 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2042?

1,738 published patents in our USPTO index have expiration dates falling in calendar year 2042.