Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2042

Annual patent cliff calendar for 2042 — US pharmaceutical patents by expiration date.

Patents
1,738

Quick answer

1,738 indexed pharmaceutical patents have expiration dates in 2042. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11331385

    Methods of preparing anti-human papillomavirus antigen T cells

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11331285

    Dosage forms and methods for enantiomerically enriched or pure bupropion

    AXSOME THERAPEUTICS, INC. · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11331346

    Targeted replacement of endogenous T cell receptors

    The Regents of the University of California · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11332499

    Cyclic peptides and methods of use thereof

    Regents of the University of Minnesota · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11332451

    RIP1 inhibitory compounds and methods for making and using the same

    Rigel Pharmaceuticals, Inc. · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11332462

    Heteroaryl compounds and methods of use thereof

    PGI Drug Discovery LLC · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11332716

    Methods and compositions for producing pancreatic beta cells

    The Regents of the University of California · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11332483

    Naphthoquinone containing gold carbene complexes and methods of uses thereof

    The Board of Regents of the University of Texas System · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11332500

    Heterotandem bicyclic peptide complexes

    BicycleTx Limited · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11332743

    Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11332746

    Compounds and methods for reducing LRRK2 expression

    Ionis Pharmaceuticals, Inc. · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11332760

    Compositions and methods for genomic editing by insertion of donor polynucleotides

    CRISPR THERAPEUTICS AG · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11332721

    Recombinant respiratory syncytial virus strains with mutations in the M2-2 ORF providing a range of attenuation phenotypes

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11332470

    CXCR4 inhibitors and uses thereof

    X4 Pharmaceuticals, Inc. · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11331395

    Hydrogel prodrug for treatment

    Viking Scientific, Inc. · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11331370

    Combination product for the prevention of sexually transmitted infections

    The United States of America · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11331363

    Phytocomplexes exhibiting multiple, synergistic antioxidant activities useful in foods, dietary supplements, cosmetics and pharmaceutical preparations

    Nature's Sunshine Products, Inc. · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11331333

    Treatment of aberrant fibroblast proliferation

    The Board of Regents of the University of Texas System · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11332722

    Development of dengue virus vaccine components

    The Government of the United States of American, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11332727

    Method for reducing an immune response by administering an immune evading adeno-associated AAV8 or AAVDJ viral vector

    The Regents of the University of California · Granted Tue May 17 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 12 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11337971

    Dopamine D3 receptor selective antagonists/partial agonists and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11337968

    Phenylquinoline compositions for treatment of ocular disorders and conditions

    The Board of Regents of the University of Oklahoma · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11337957

    Compositions comprising urolithin compounds

    Amazentis SA · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11338029

    Cancer vaccines targeting PRAME and uses thereof

    Inovio Pharmaceuticals, Inc. · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11337969

    Methods for treating cancer

    X4 Pharmaceuticals, Inc. · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11338003

    Methods of treating bladder cancer with an oncolytic virus

    CG ONCOLOGY, INC. · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11339156

    3-(1H-pyrazol-4-yl)pyridine allosteric modulators of the M4 muscarinic acetylcholine receptor

    MSD R&D (China) Co. Ltd. · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11339160

    Imidazole and triazole containing bicyclic compounds as JAK inhibitors

    Theravance Biopharma R&D IP, LLC · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11339112

    Compositions and methods comprising resveratrol

    Biocogent, LLC · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11338026

    Identification of immunologically protective neo-epitopes for the treatment of cancers

    UNIVERSITY OF CONNECTICUT · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11338028

    Cancer vaccines targeting LEMD1 and uses thereof

    Inovio Pharmaceuticals, Inc. · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11338119

    Implantable drug delivery devices for localized drug delivery

    The Regents of the University of California · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11338033

    Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11339198

    Codon optimized IL-15 and IL-15R-alpha genes for expression in mammalian cells

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11339150

    Benzimidazole compounds as HDAC6 inhibitors

    OnKure, Inc. · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11338032

    Methods of preparing anti-human papillomavirus antigen T cells

    THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11337998

    Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

    Iovance Biotherapeutics, Inc. · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11337989

    Compositions and methods for inhibiting inflammation and diseases using an alginic acid-based antimicrobial compound

    Evofem, Inc. · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11338013

    Combination therapy for C3 inhibition

    Apellis Pharmaceuticals, Inc. · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11338037

    Ultrastable antibody ionic liquids

    United States of America as represented by the Secretary of the Air Force · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11337988

    Use of ouabain antagonists to inhibit viral infection

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11337941

    Inhibitors and their uses

    United Kingdom Research and Innovation · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11338041

    Exon skipping oligomer conjugates for muscular dystrophy

    Sarepta Therapeutics, Inc. · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11339129

    Triazabutadienes as cleavable cross-linkers

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11339169

    P2X3 and/or P2X2/3 compounds and methods

    Asana BioSciences, LLC · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11338118

    Swallowable drug delivery device and methods of drug delivery

    Rani Therapeutics, LLC · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11339141

    Methods and compounds for restoring mutant p53 function

    PMV PHARMACEUTICALS, INC. · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11339170

    Spiropyrrolidine derived antiviral agents

    Enanta Pharmaceuticals, Inc. · Granted Tue May 24 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon May 19 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2042?

1,738 published patents in our USPTO index have expiration dates falling in calendar year 2042.