Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2042

Annual patent cliff calendar for 2042 — US pharmaceutical patents by expiration date.

Patents
1,738

Quick answer

1,738 indexed pharmaceutical patents have expiration dates in 2042. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11299492

    JAK kinase inhibitor compounds for treatment of respiratory disease

    Theravance Biopharma R&D IP, LLC · Granted Tue Apr 12 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 07 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11298441

    Biodegradable biomimetics of growth plate cartilage for the treatment of physeal injuries

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Apr 12 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 07 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11298424

    Non-ionic and thermoresponsive diblock copolypeptide hydrogels for delivery of molecules and cells

    The Regents of the University of California · Granted Tue Apr 12 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 07 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11298350

    Subcutaneous delivery of polymer conjugates of therapeutics agents

    Serina Therapeutics, Inc. · Granted Tue Apr 12 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 07 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11298430

    Magnetic nanocomposite compositions

    Northwestern University · Granted Tue Apr 12 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 07 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11298309

    Topical silk compositions and methods of using

    The Regents of the University of Colorado · Granted Tue Apr 12 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 07 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11299515

    Optimized peptides for targeting human nerves and their use in image guided surgery, diagnostics and therapeutic

    The Regents of the University of California · Granted Tue Apr 12 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 07 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11299533

    Purification of factor VIII subspecies

    Takeda Pharmaceutical Company Limited · Granted Tue Apr 12 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 07 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. WO 2022074143

    DÉRIVÉS DE BENZO[H]QUINAZOLIN-4-AMINE ET DE THIÉNO[3,2-H]QUINAZOLIN-4-AMINE POUR LE TRAITEMENT DU CANCER

    BASILEA PHARM INT AG [CH] · Granted Thu Apr 14 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Apr 09 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. TW 202214258

    Compounds and methods for treating fungal infections

    AMPLYX PHARMACEUTICALS INC [US] · Granted Sat Apr 16 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Fri Apr 11 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11306104

    Solid state forms of Relugolix

    TEVA PHARMACEUTICALS INTERNATIONAL GMBH · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11306077

    Compounds, compositions and methods

    DENALI THERAPEUTICS INC. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11306123

    Heterotandem bicyclic peptide complex

    BicycleTx Limited · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11306150

    Method of identifying a P-selectin glycoprotein ligand-1 (PSGL-1) antagonist

    Five Prime Therapeutics, Inc. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11304904

    Manufacturing of bupivacaine multivesicular liposomes

    Pacira Pharmaceuticals, Inc. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11304895

    Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device

    Rani Therapeutics, LLC · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11304879

    Adhesive composition for dental use

    KURARAY NORITAKE DENTAL INC. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11304935

    Use of I-BRD9 or derivatives thereof in preparing anti-epileptic drugs

    University of South China · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11304926

    Application of transient receptor potential cation channel TRPV3 in developing drug for preventing or treating psoriasis

    CHINA PHARMACEUTICAL UNIVERSITY · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11304914

    Polymorphic and amorphous forms of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide

    PTC THERAPEUTICS, INC. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11304911

    Compositions and methods for organ specific delivery of nucleic acids

    The Board of Regents of the University of Texas System · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11304950

    Methods for treating testicular and ovarian adrenal rest tumors

    SPRUCE BIOSCIENCES, INC. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11304959

    Vaginal inserted estradiol pharmaceutical compositions and methods

    Compass Therapeutics LLC · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11304988

    Inhibiting tumor cell migration by inhibition of kinesin light chain 1, variant 1 (KLC1C)

    Northwestern University · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11306115

    Aminoglycoside derivatives and uses thereof in treating genetic disorders

    ELOXX PHARMACEUTICALS LTD. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11304980

    Restimulation of cryopreserved tumor infiltrating lymphocytes

    Iovance Biotherapeutics, Inc. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11304996

    Yeast-based immunotherapy and type I interferon sensitivity

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11305002

    Compositions and treatments for Haemophilus influenzae

    The Board of Regents of the University of Oklahoma · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11305022

    Methods for distributing high levels of therapeutic agent throughout the cortex to treat neurological disorders

    The Regents of the University of California · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 11306088

    CXCR4 inhibitors and uses thereof

    X4 Pharmaceuticals, Inc. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11306095

    Use of pteridinone derivative serving as EGFR inhibitor

    East China University of Science and Technology · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11306155

    Methods for treating patients with heterozygous familial hypercholesterolemia (heFH) with an anti-PCSK9 antibody

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11304993

    Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins

    Rani Therapeutics, LLC · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11306098

    Substituted pyrrolo[1,2-a]pyrazines and pyrrolo[1,2-a][1,4]diazepines as TREX1 inhibitors

    VENENUM BIODESIGN, LLC · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11306288

    Methods for preparing therapeutically active cells using microfluidics

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11306135

    Anti-VEGF protein compositions and methods for producing the same

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11306132

    HLA class II-restricted T cell receptors against mutated RAS

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11306122

    Compositions and methods of inhibiting the binding of plasma IgG autoantibodies to serotonin 2A receptor

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11306121

    Composition for muscle relaxation

    CAREGEN CO., LTD. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11306130

    PAR3 mimetic peptides and uses thereof

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11305009

    Recombinant virus with diminished latency and methods of using same

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11304979

    Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

    Iovance Biotherapeutics, Inc. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11304916

    Methods and compositions for the treatment of Shiga Toxicosis

    The Board of Regents of the University of Texas System · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11306131

    T cell receptors recognizing HLA-A1- or HLA-CW7-restricted mage

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11306144

    B7-H4 antibodies and methods of use thereof

    Five Prime Therapeutics, Inc. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11306148

    Anti-NPR1 antibodies and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11306149

    Anti-CD40 antibodies and uses thereof

    CytomX Therapeutics, Inc. · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11306287

    Method of generating skeletal muscle stem cells from pluripotent cells

    Regents of the University of Minnesota · Granted Tue Apr 19 2022 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 14 2042 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2042?

1,738 published patents in our USPTO index have expiration dates falling in calendar year 2042.