Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2041

Annual patent cliff calendar for 2041 — US pharmaceutical patents by expiration date.

Patents
2,000

Quick answer

2,000 indexed pharmaceutical patents have expiration dates in 2041. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11197916

    Lyophilized recombinant VWF formulations

    Takeda Pharmaceutical Company Limited · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 11197869

    Istaroxime-containing intravenous formulation for the treatment of acute heart failure (AHF)

    Windtree Therapeutics, Inc. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 11197847

    Isoxazoline parasiticide formulations and methods for treating blepharitis

    Tarsus Pharmaceuticals, Inc. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 11197821

    Formulations for treatment of dry eye disease

    Aldeyra Therapeutics, Inc. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 11198689

    Compositions and methods for inhibition of the JAK pathway

    Rigel Pharmaceuticals, Inc. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 11197812

    Cosmetic formulations for topical applications containing erythropoietin-derived molecules

    ASC REGENITY LIMITED · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 11198876

    Compositions and methods for inhibiting expression of TMPRSS6 gene

    Alnylam Pharmaceuticals, Inc. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 11198872

    Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 11198858

    Codon optimized GLA genes and uses thereof

    4D MOLECULAR THERAPEUTICS INC. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 11198724

    Treatment of staphylococcal disorders

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 11198691

    N-((het)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors

    KalVista Pharmaceuticals Limited · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 11198699

    Compounds targeting PRMT5

    Aligos Therapeutics, Inc. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 11198682

    Substituted pyrimidines as inhibitors for a Rho family of GTP-ases

    The Regents of the University of California · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 11197932

    Polymer-drug conjugates for combination anticancer therapy

    The Regents of the University of California · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 11197928

    Sustained production of high affinity antigen specific antibody by high dose BAFF receptor-targeting mAb-siRNA conjugate

    The Board of Regents of the University of Texas System · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 11198685

    Substituted ureas and methods of making and using same

    Mebias Discovery, Inc. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 11197923

    Methods and compositions for live attenuated viruses

    Takeda Vaccines, Inc. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 11198686

    Crystal form and salt form of pyridone compound and preparation method therefor

    Medshine Discovery Inc. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 11197907

    Antimicrobial compounds from the genus Delftia

    TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 11197884

    Modulation of the notch signaling pathway for treatment of respiratory disorders

    Ionis Pharmaceuticals, Inc. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 11197883

    Inhibition of stress granule formation through manipulation of UBAP2L

    The Regents of the University of California · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 11197870

    Treatment for hepatic fibrosis

    GALMED RESEARCH AND DEVELOPMENT LTD · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 11197879

    Flavonoid compositions and uses thereof

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 11197876

    Effects of LGM2605 on a primate model of asthma

    The Regents of the University of California · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 11197833

    Fortified CBD oil for treatment of PTSD

    Bright Green Corporation · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 11197844

    Triple drug combination (metformin, simvastatin, digoxin) for targeted treatment of pancreatic cancer

    The Regents of the University of California · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 11197837

    Methods and compositions for interfering with extraction or conversion of a drug susceptible to abuse

    Acurx Pharmaceuticals, Inc. · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 11197822

    Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract

    The Regents of the University of California · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 11202152

    Acoustic beamforming

    The Regents of the University of California · Granted Tue Dec 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 2021387969

    BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 AND/OR M4 RECEPTOR AGONISTS

    HEPTARES THERAPEUTICS LTD [GB] · Granted Thu Dec 16 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Dec 11 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 11203602

    Thioester prodrugs of macrocycles as inhibitors of histone deacetylases

    OnKure, Inc. · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 11203618

    Campylobacter immunogenic compositions and uses thereof

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 11203754

    Microrna compositions and methods of making and using same

    Advanced ReGen Medical Technologies, LLC · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 11203583

    Prodrug and profluorescent compounds for selective mitochondrial imaging and therapeutic targeting

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 11203596

    Analogs of 3-amino-4-(propan-2-ylidene)cyclopentane-1-carboxylic acid and uses thereof for treating diseases and disorders associated with ornithine aminotransferase activity

    Northwestern University · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 11203582

    Benzamide derivatives for inhibiting endoplasmic reticulum (ER) stress

    The Board of Regents of the University of Oklahoma · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 11202819

    Use of C-type natriuretic peptide variants to treat osteoarthritis

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 11202784

    Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency

    Corcept Therapeutics Incorporated · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 11203581

    Highly purified pharmaceutical grade tasimelteon

    VANDA PHARMACEUTICALS INC. · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 11203572

    Substituted benzamides and methods of use thereof

    Xenon Pharmaceuticals Inc. · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 11203571

    Sulfonamides as modulators of sodium channels

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 11202824

    Peptide fragments from filoviruses and their uses

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 11202823

    Multi-subunit vaccines to elicit both MHC- and CD1-restricted T cell responses

    Northwestern University · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 11202822

    Methods for treating hypophosphatemic disorders

    Ultragenyx Pharmaceutical Inc. · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 11202808

    Methods for treating autism spectrum disorder and associated symptoms

    ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 11202803

    Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy

    Iovance Biotherapeutics, Inc. · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 11202802

    Materials and methods for engineering cells and uses thereof in immuno-oncology

    CRISPR THERAPEUTICS AG · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 11202789

    Method of treating glycogen storage disease

    Viking Therapeutics, Inc. · Granted Tue Dec 21 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 16 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2041?

2,000 published patents in our USPTO index have expiration dates falling in calendar year 2041.