Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Patents expiring in 2041

Annual patent cliff calendar for 2041 — US pharmaceutical patents by expiration date.

Patents
2,000

Quick answer

2,000 indexed pharmaceutical patents have expiration dates in 2041. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 11141378

    Lipid formulations for nucleic acid delivery

    ARBUTUS BIOPHARMA CORPORATION · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 11142760

    Compositions and methods for treating hemoglobinopathies

    Beam Therapeutics Inc. · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 11142766

    Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 11141398

    Methods for decreasing injuries associated with intraoperative hypotension

    United States Government as represented by the Department of Veterans Affairs · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 11142764

    Antisense antibacterial compounds and methods

    The Board of Regents of the University of Texas System · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 11142765

    Reagents for treatment of oculopharyngeal muscular dystrophy (OPMD) and use thereof

    Benitec IP Holdings Inc. · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 11142750

    Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome

    Precision BioSciences, Inc. · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 11142530

    Deep-sea fungus-derived anthraquinone compound and use thereof in preparing anti-allergic drugs

    China Ocean Mineral Resources R&D Association · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 11141400

    Method of treatment

    VANDA PHARMACEUTICALS INC. · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 11141393

    Treatment of vasculopathy with prostacyclin and mesenchymal stem cells

    United Therapeutics Corporation · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 11141404

    Formulations and methods for treating acute cannabinoid overdose

    Anebulo Pharmaceuticals, Inc. · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 11141418

    Methods and compositions for KRAS inhibitors

    The Board of Regents of the University of Texas System · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 11141465

    Method of making a water-soluble polymer-factor VIII moiety conjugate

    Nektar Therapeutics · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 11141493

    Compositions and methods for treating CEP290-associated disease

    Editas Medicine, Inc. · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 11141496

    Use of berberine or derivative thereof in preparing myocardial perfusion imaging agent

    WEST CHINA HOSPITAL, SICHUAN UNIVERSITY · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 11141438

    Restimulation of cryopreserved tumor infiltrating lymphocytes

    Iovance Biotherapeutics, Inc. · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 11141452

    Bifunctional compounds for relief of pain comprising an opioid receptor agonist moiety and a NK1 receptor antagonist moiety and methods for treating pain

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 11142504

    Substituted heterocycles as c-MYC targeting agents

    Northwestern University · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 11141479

    Stable anti-OSMR antibody formulation

    Kiniksa Pharmaceuticals, GmbH · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 11142533

    Macrocycles for use in treating disease

    TURNING POINT THERAPEUTICS, INC. · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 11142505

    Compositions for APP-selective BACE inhibition and uses therefor

    The Regents of the University of California · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 11142527

    Dihydropyrimidine compounds and uses thereof in medicine

    SUNSHINE LAKE PHARMA CO., LTD. · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 11142583

    BCMA-CAR-natural killer (NK) cells and methods related thereto

    Caribou Biosciences, Inc. · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 11142578

    Anti-MET antibodies, bispecific antigen binding molecules that bind MET, and methods of use thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 11141434

    Programmed death 1 ligand 1 (PD-L1) binding proteins and methods of use thereof

    Iovance Biotherapeutics, Inc. · Granted Tue Oct 12 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 07 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. CA 3174748

    UTILISATION DE MASITINIB POUR LE TRAITEMENT DE LA MALADIE A CORONAVIRUS 2019 (COVID-19)

    AB SCIENCE [FR] · Granted Thu Oct 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 2021315993

    PHOTODYNAMIC THERAPY COMPRISING TWO LIGHT EXPOSURES AT DIFFERENT WAVELENGTHS

    BIOFRONTERA BIOSCIENCE GMBH [DE] · Granted Thu Oct 14 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Oct 09 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 11149253

    Small molecule compound combination for reprogramming digestive tract derived epithelial cells to endodermal stem/progenitor cells, reprogramming method and application

    INSTITUTE OF TRANSFUSION MEDICINE, ACADEMY OF MILITARY MEDICAL SCIENCES, PEOPLE'S LIBRATION ARMY OF CHINA · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 11150237

    Patient-specific biomarkers of Escherichia coli invasion in inflammatory bowel disease

    The Regents of the University of California · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 11149273

    Lipid formulated compositions and methods for inhibiting expression of serum amyloid A gene

    Alnylam Pharmaceuticals, Inc. · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 11147946

    Venous access catheters and methods for portal venous system catheterization

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 11149020

    MAP kinase modulators and uses thereof

    Northwestern University · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 11147867

    Stabilized influenza hemagglutinin stem region trimers and uses thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 11147883

    Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells

    EnGeneIC Molecular Delivery Pty Ltd · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 11147888

    Methods and systems for detecting psychotic disorders associated with serotonin 2A receptor deficiencies

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 11149000

    Carbamoyl phenylalaninol compounds and uses thereof

    Jazz Pharmaceuticals Ireland Limited · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 11149002

    Therapeutic compounds and methods of use thereof

    Xenon Pharmaceuticals Inc. · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 11148998

    Dimethyl-nonatetraenyl-trimethyl-cyclohexyl compounds and uses thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 11149036

    3-(1H-pyrazol-4-yl)pyridine allosteric modulators of the M4 muscarinic acetylcholine receptor

    MSD R&D (China) Co. Ltd. · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 11149044

    Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use

    Compass Pathfinder Limited · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 11149047

    Aryl imidazoles for treatment of cancer

    APTOSE BIOSCIENCES INC. · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 11149073

    ROR1-specific chimeric antigen receptors (CAR) with humanized targeting domains

    Julius-Maximilians-Universitat Wurzburg · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 11149082

    Multispecific antibodies targeting human immunodeficiency virus and methods of using the same

    The United States of America, As Represented By · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 11147841

    Enhanced omega-3 formulations

    AKER BIOMARINE ANTARCTIC AS · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. US 11149251

    Methods for preparing therapeutically active cells using microfluidics

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 11149321

    Methods and compositions for targeted single-stranded cleavage and targeted integration

    Sangamo Therapeutics, Inc. · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 11149276

    Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 11147746

    Hydrophobic dental surfaces

    Regents of the University of Minnesota · Granted Tue Oct 19 2021 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Oct 14 2041 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2041?

2,000 published patents in our USPTO index have expiration dates falling in calendar year 2041.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.