Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2038

Annual patent cliff calendar for 2038 — US pharmaceutical patents by expiration date.

Patents
1,509

Quick answer

1,509 indexed pharmaceutical patents have expiration dates in 2038. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 10016484

    Methods of treating lung cancer

    Five Prime Therapeutics, Inc. · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 10016486

    Methods and compositions using AMPK activators for pharmacological prevention of chronic pain

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 10016490

    Multiple-enzyme nanocomplexes

    The Regents of the University of California · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 10016499

    Multifunctional metal nanoparticles having a polydopamine-based surface and methods of making and using the same

    Northwestern University · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 10016498

    D-amino acid derivative-modified peptidoglycan and methods of use thereof

    The Regents of the University of California · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 10016491

    Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases

    HALOZYME, INC. · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 10016517

    Bioactive amphiphilic polymer stabilized nanoparticles with enhanced stability and activity

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 10017508

    Nitrogenated heterocyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 10017495

    Therapeutically active compounds and their methods of use

    Agios Pharmaceuticals, Inc. · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 10017516

    BMP inhibitors and methods of use thereof

    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER—NATIONAL INSTITUTES OF HEALTH · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 10017543

    Prefusion RSV F proteins and their use

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 10017734

    Method for producing dopaminergic neurons

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 10017551

    Peptides having reduced toxicity that stimulate cholesterol efflux

    The Regents of the University of California · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 10017598

    Block copolymer and micelle compositions and methods of use thereof

    The Board of Regents of the University of Texas System · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 10017762

    Compositions and methods for treating or preventing lupus

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 10018638

    Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using ELISA assays

    The Board of Regents of the University of Texas System · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 10016474

    Plant extract, compositions containing same, method of extraction and uses thereof

    Botanic Century (Beijing) Co. Ltd. · Granted Tue Jul 10 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 05 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. WO 2018128828

    NOUVEAUX MIMÉTIQUES D'HEPCIDINE ET LEURS UTILISATIONS

    BAYER HEALTHCARE LLC [US] · Granted Thu Jul 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Jul 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 10023581

    Modified cytotoxins and their therapeutic use

    The Regents of the University of California · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 10022347

    Compositions and methods for diagnosis and treatment of metabolic syndrome

    United States of America as represented by the Secretary of the Air Force · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 10022364

    Methods of treating cancer patients with farnesyltransferase inhibitors

    Kura Oncology, Inc. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 10022375

    Methods and compositions for inhibition of polymerase

    BioCryst Pharmaceuticals, Inc. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 10022385

    Thermo-kinetic mixing for pharmaceutical applications

    The Board of Regents of the University of Texas System · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 10022456

    Reversibly masked polymers

    Arrowhead Pharmaceuticals, Inc. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 10022450

    Regulation of specific spinal neurons regulating pain transmission via chimeric toxins

    The Regents of the University of California · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 10023569

    Methods of preparing inhibitors of influenza viruses replication

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 10023587

    Oxabicycloheptanes and oxabicycloheptenes, their preparation and use

    Lixte Biotechnology, Inc. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 10022325

    Compositions and methods for the treatment of cancer

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 10023588

    Compositions and methods for treating cancer

    The Regents of the University of California · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 10023627

    Vascular endothelial growth factor fusion protein

    KOREA PRIME PHARM CO., LTD. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 10023628

    Cell line expressing single chain factor VIII polypeptides and uses thereof

    BIOVERATIV THERAPEUTICS INC. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 10023637

    Combination immunotherapy for the treatment of cancer

    The Board of Regents of the University of Texas System · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 10023652

    Method of targeting glycoproteins to treat cancer

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 10023642

    Anti-PDGFR-beta antibodies and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 10023644

    Antigen-binding proteins that activate the leptin receptor

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 10023650

    Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers

    PRECISION BIOLOGICS, INC. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 10023654

    Anti-PCSK9 antibodies

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10023848

    Immunogenic composition comprising Panton-Valentine Leukocidin (PVL) derived polypeptides

    INTEGRATED BIOTHERAPEUTICS, INC. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10023862

    Organic compositions to treat beta-catenin-related diseases

    Arrowhead Pharmaceuticals, Inc. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10023879

    Minimal volume reprogramming of mononuclear cells

    Fate Therapeutics, Inc. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 10023641

    Anti-TIE2 antibodies and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10023614

    Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases

    Protagonist Therapeutics, Inc. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10023916

    Markers of tumor cell response to anti-cancer therapy

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10022382

    RNA polymerase I inhibitors and uses thereof

    TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 10023544

    Heterocyclic compound

    Takeda Pharmaceutical Company Limited · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10022352

    Modulators of ATP-binding cassette transporters

    Vertex Pharmaceuticals Incorporated · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10022367

    Sustained-release buprenorphine solutions

    Indivior UK Limited · Granted Tue Jul 17 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 12 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10030244

    Serpina1 iRNA compositions and methods of use thereof

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jul 24 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jul 19 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2038?

1,509 published patents in our USPTO index have expiration dates falling in calendar year 2038.