Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2038

Annual patent cliff calendar for 2038 — US pharmaceutical patents by expiration date.

Patents
1,509

Quick answer

1,509 indexed pharmaceutical patents have expiration dates in 2038. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 9994585

    Transplantation therapies

    Aphios Corporation · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 9994817

    Use of ligands for the programmed cell death receptor conjugated to solid supports for cultivating human regulatory T cells

    Northwestern University · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 9993453

    Dosage forms and therapeutic uses L-4-chlorokynurenine

    VISTAGEN THERAPUETICS, INC. · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 9993510

    Acne-removing traditional chinese medicine composition and preparation method thereof

    INFINITUS (CHINA) COMPANY LTD. · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 9993449

    (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid, and related compounds as GABA aminotransferase inactivators for the treatment of epilepsy, addiction and hepatocellular carcinoma

    Northwestern University · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 9993450

    Dosage forms and therapeutic uses of L-4-chlorokynurenine

    VISTAGEN THERAPUETICS, INC. · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 9993437

    Mesoporous silica nanoparticles for biomedical applications

    The Regents of the University of California · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 9993394

    Dental restorative composition

    KURARAY NORITAKE DENTAL INC. · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 9993481

    Methods and compositions for the treatment of metabolic disorders

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 9994617

    Modulation of structured polypeptide specificity

    BicycleRD Limited · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 9993501

    Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene

    Precision BioSciences, Inc. · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 9993440

    Enzyme responsive nanocapsules for protein delivery

    The Regents of the University of California · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 9993660

    Method of using laser-induced optoacoustics for the treatment of drug-resistant microbial infections

    The United States of America as represented by the Secretary of Navy · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 9994566

    Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryl or heteroaryl, preparation method thereof and pharmaceutical use thereof

    Shenyang Sunshine Pharmaceutical Co., LTD · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 9993553

    Methods and compositions for targeted release of molecules from nanoscale carriers

    The Regents of the University of California · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 9994542

    Prodrugs of urolithins and uses thereof

    Amazentis SA · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 9994584

    Process of synthesizing 3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1] heptane-2-carboxylic acid

    Lixte Biotechnology, Inc. · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 9993765

    Portable oxygen enrichment device and method of use

    SEPARATION DESIGN GROUP LLC · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 9994527

    Modified amino acids

    Sutro Biopharma, Inc. · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 9994558

    Multicyclic compounds and methods of using same

    Karyopharm Therapeutics Inc. · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 9993502

    Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene

    Precision BioSciences, Inc. · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 9993543

    Immunogenic compositions comprising silicified virus and methods of use

    Providence Health & Services—Oregon · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 9993503

    Methods for production of platelets from pluripotent stem cells and compositions thereof

    Astellas Institute for Regenerative Medicine · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 9993537

    Methods and compositions related to Th-1 dendritic cells

    The Board of Regents of the University of Texas System · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 9993529

    Stable formulations of a hyaluronan-degrading enzyme

    HALOZYME, INC. · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 9993642

    Multi-site transcutaneous electrical stimulation of the spinal cord for facilitation of locomotion

    The Regents of the University of California · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 9994600

    Prodrug compounds and uses therof

    Ligand Pharmaceuticals Incorporated · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 9993461

    Method for treating disorders associated with glomerular function

    Ligand Pharmaceuticals Incorporated · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 9994814

    Method for cellular restoration

    Advanced ReGen Medical Technologies, LLC · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 9994613

    Prodrug of an ICE inhibitor

    Vertex Pharmaceuticals Incorporated · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 9994852

    Oligonucleotide compositions and uses thereof

    MIRAGEN THERAPEUTICS, INC. · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 9994860

    Regulating alkaloids

    22ND CENTURY LIMITED, LLC · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 9994910

    Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571

    The Regents of the University of California · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 9994856

    Method for increasing the activity of a cystic fibrosis transmembrane conductance regulator protein

    ProQR Therapeutics II B.V. · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 9994847

    miR-29 mimics and uses thereof

    MIRAGEN THERAPEUTICS, INC. · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 9994855

    Compositions and methods for modulating growth hormone receptor expression

    Ionis Pharmaceuticals, Inc. · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 9994901

    Pro-inflammatory mediators in diagnosis and treatment of chronic obstructive pulmonary disease

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Jun 12 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 07 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 10000479

    Compounds and their methods of use

    Agios Pharmaceuticals, Inc. · Granted Tue Jun 19 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 10000468

    Pyrazines as modulators of GPR6

    Takeda Pharmaceutical Company Limited · Granted Tue Jun 19 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 10000525

    Non-hormonal steroid modulators of NF-κB for treatment of disease

    ReveraGen BioPharma, Inc. · Granted Tue Jun 19 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 9999673

    PEGylated lipids and their use for drug delivery

    Alnylam Pharmaceuticals, Inc. · Granted Tue Jun 19 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 10001495

    Blood factor monitoring assay and uses thereof

    BIOVERATIV THERAPEUTICS INC. · Granted Tue Jun 19 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 10000523

    β-D-2′-deoxy-2′-α-fluoro-2′-β-C-substituted-2-modified-N6-substituted purine nucleotides for HCV treatment

    Atea Pharmaceuticals, Inc. · Granted Tue Jun 19 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 10000813

    Method of diagnosing and treating cancer using B-catenin splice variants

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Jun 19 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 10000522

    Derivatives of uridine 5′-cyclophosphate useful to treat hepatitis C viral infections

    Ligand Pharmaceuticals Incorporated · Granted Tue Jun 19 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 10000551

    Chimeric polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same

    Protalix Ltd. · Granted Tue Jun 19 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 10000456

    Polycyclic compounds as lysophosphatidic acid receptor antagonists

    AMIRA PHARMACEUTICALS, INC. · Granted Tue Jun 19 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 10000556

    Single-domain VHH antibodies directed to norovirus GI.1 and GII.4 and their use

    The United States of America as Represented by the Secretary, Dept. of Health and Human Services · Granted Tue Jun 19 2018 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Jun 14 2038 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2038?

1,509 published patents in our USPTO index have expiration dates falling in calendar year 2038.