Wednesday, June 10, 2026
🇺🇸 FDA

Intelligence · Patents

Patents expiring in 2035

Annual patent cliff calendar for 2035 — US pharmaceutical patents by expiration date.

Patents
1,447

Quick answer

1,447 indexed pharmaceutical patents have expiration dates in 2035. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 9012434

    Natural combination hormone replacement formulations and therapies

    Compass Therapeutics LLC · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  2. US 9012508

    Administration of intravenous ibuprofen

    Cumberland Pharmaceuticals Inc. · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  3. US 9012498

    Biodegradable lipids for the delivery of active agents

    Alnylam Pharmaceuticals, Inc. · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  4. US 9012460

    1-(2-phenoxymethylphenyl)piperazine compounds

    Theravance Biopharma R&D IP, LLC · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  5. US 9012496

    Pharmaceutical compositions of (R)-1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide and administration thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  6. US 9012469

    Crystalline naloxol-peg conjugate

    Nektar Therapeutics · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  7. US 9012641

    Crystalline forms of Prasugrel salts

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  8. US 9012506

    Cross-linked fatty acid-based biomaterials

    ATRIUM MEDICAL CORPORATION · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  9. US 9012473

    Modulators of ATP-binding cassette transporters

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  10. US 9012624

    Compositions and methods for inhibiting expression of a gene from the JC virus

    Alnylam Pharmaceuticals, Inc. · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  11. US 9012485

    Dual-acting imidazole antihypertensive agents

    Theravance Biopharma R&D IP, LLC · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  12. US 9012647

    Nitroxide modified non-steroidal anti-inflammatory compounds and uses thereof in the treatment and prevention of diseases or disorders

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  13. US 9012618

    Nucleic acids encoding modified Ebola virus glycoproteins with diminished cytotoxicity while retaining native antigenic structures

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  14. US 9012467

    Compositions for intratumoral administration

    Covidien LP · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  15. US 9012447

    5-HT3 receptor antagonists

    Takeda Pharmaceutical Company Limited · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  16. US 9012223

    Methods for enhancing genome stability and telomere elongation in embryonic stem cells

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  17. US 9011913

    Use of functionalized magnetic nanoparticles in cancer detection and treatment

    The Regents of the University of California · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  18. US 9011857

    Methods of treating cancer by administering EMP2 antibodies

    The Regents of the University of California · Granted Tue Apr 21 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 16 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  19. US 2015112285

    Transdermal Therapeutic System For Administering Rivastigmine Or Derivatives Thereof

    ACINO AG [DE] · Granted Thu Apr 23 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Apr 18 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  20. US 9017644

    Methods of treating autoimmune disorders and/or inflammatory disorders

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  21. US 9017661

    Cardiac repair by reprogramming of cardiac fibroblasts into cardiomyocytes

    The Board of Regents of the University of Texas System · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  22. US 9017653

    Nitric oxide-releasing compositions and methods

    The Board of Regents of the University of Texas System · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  23. US 9017670

    Anti-Tie2 antibodies and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  24. US 9018162

    Methods for rapidly treating severe hypoglycemia

    XERIS PHARMACEUTICALS, INC. · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  25. US 9017725

    Topical drug delivery systems for ophthalmic use

    AURINIA PHARMACEUTICALS INC. · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  26. US 9018216

    Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  27. US 9018227

    Nicotinic acetylcholine receptor agonists

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  28. US 9017982

    Non-wild-type organophosphorus acid anhydrolases for enzymatic decontamination

    The United States of America as represented by the Secretary of the Army · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  29. US 9018210

    Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation

    The Regents of the University of California · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  30. US 9018238

    Inhibitor of casein kinase 1δ and casein kinase 1ε

    Pharmadesign, Inc. · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  31. US 9018204

    2,4-pyrimidinediamine compounds and their uses

    Rigel Pharmaceuticals, Inc. · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  32. US 9018236

    Cyclodextrin-based microemulsions, and dermatological uses thereof

    Precision Dermatology, Inc. · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  33. US 9018170

    Reduced volume formulation of glatiramer acetate and methods of administration

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  34. US 9018251

    Method for treating brain cancer or reducing temozolomide-resistance of brain cancer cells

    China Medical University · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  35. US 9017743

    Bacterial extract for digestive or urinary tract disorders and process for its preparation

    OM PHARMA · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  36. US 9018374

    Crystal of amide compound

    Takeda Pharmaceutical Company Limited · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  37. US 9018371

    Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient

    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER—NATIONAL INSTITUTES OF HEALTH · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  38. US 9018380

    Heterocyclic modulators of HIF activity for treatment of disease

    Boards of Regents, The University of Texas System · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  39. US 9018356

    Anti-ANGPTL3 antibodies and uses thereof

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  40. US 9018201

    Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) for use in treatment of diseases associated with a PTEN deficiency

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  41. US 9018175

    3,4,4a,10b-Tetrahydro-1H-thiopyrano-[44,3-c] isoquinoline derivatives

    TAKEDA GMBH · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  42. US 9017730

    Compositions and uses of materials with high antimicrobial activity and low toxicity

    The Regents of the University of California · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  43. US 9018244

    Benzopyran compounds, compositions and uses thereof

    Olema Pharmaceuticals, Inc. · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  44. US 9018367

    Single stranded DNA aptamers binding NF-κB/RelA

    The Board of Regents of the University of Texas System · Granted Tue Apr 28 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 23 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  45. IL 172160

    Method for non-invasive quantification of perfusion in a tissue

    BRACCO SUISSE SA [CH] · Granted Thu Apr 30 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Apr 25 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  46. US 9023809

    Phenylalanine dipeptide derivatives, compositions and use thereof

    302 Hospital of PLA, China · Granted Tue May 05 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 30 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  47. US 9023322

    Chewing gum compositions comprising cannabinoids

    Stichting Sanammad · Granted Tue May 05 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 30 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

  48. US 9023371

    Drug releasing coatings for medical devices

    Lutonix, Inc. · Granted Tue May 05 2015 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 30 2035 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2035?

1,447 published patents in our USPTO index have expiration dates falling in calendar year 2035.

Drug approvals, clinical trials, M&A, event intelligence, and company updates — weekly.

Customize topics & region
Topics
Region

No spam. Unsubscribe anytime. See our privacy policy.