Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2033

Annual patent cliff calendar for 2033 — US pharmaceutical patents by expiration date.

Patents
1,330

Quick answer

1,330 indexed pharmaceutical patents have expiration dates in 2033. Browse by soonest expiry with links to assignee companies and related drugs.

  1. DE 102011114864

    Verfahren zur Herstellung einer homogenen Pulvermischung und Verfahren zur Herstellung eines Implantats sowie Implantat

    ACINO AG [DE] · Granted Thu Apr 11 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Apr 06 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 8420816

    Dihydropyrrolonaphthyridinone compounds as inhibitors of JAK

    Takeda Pharmaceutical Company Limited · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 8420669

    Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the BETA2 adrenergic receptor

    Laboratories Almirall, S.A. · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 8420619

    Rescue of photoreceptors by intravitreal administration of an expression vector encoding a therapeutic protein

    Ceregene, Inc. · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 8420596

    Macrocyclic hepatitis C serine protease inhibitors

    Enanta Pharmaceuticals, Inc. · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 8420068

    Polymer-based compositions and conjugates of antimicrobial agents

    Nektar Therapeutics · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 8420607

    Anthrax carbohydrates, synthesis and uses thereof

    The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 8420612

    Diabetes treatment methods and drug targets therefor

    The Regents of the University of California · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 8420118

    Anionic lipids and lipid nano-structures and methods of producing and using same

    The Board of Regents of the University of Oklahoma · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 8420072

    Vaccination of sex reversed hybrid tilapia (Oreochromis niloticus x O. aureus) with an inactivated Vibrio vulnificus vaccine

    The United States of America, as represented by the Secretary of Agriculture · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 8420686

    Linked diimidazole antivirals

    Enanta Pharmaceuticals, Inc. · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 8420664

    A3 adenosine receptor allosteric modulators

    THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPT. HEALTH & HUMAN SERVICES · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 8420665

    Anti-cancer compounds

    Northwestern University · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 8420099

    Chimeric protein for prevention and treatment of HIV infection

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 8420368

    Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 8420659

    Compositions and methods for inhibition of the JAK pathway

    Rigel Pharmaceuticals, Inc. · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 8420678

    Small molecule inhibitors of the pleckstrin homology domain and methods for using same

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 8420885

    Determining the capability of a test compound to affect solid tumor stem cells

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 8420852

    Phospholipase A2 inhibitors and their use in treating neurological injury and disease

    The Regents of the University of California · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 8420694

    Pyrrolidin-2-one derivatives as androgen receptor modulator

    Takeda Pharmaceutical Company Limited · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 8420799

    Therapeutic compositions

    Alnylam Pharmaceuticals, Inc. · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 8420107

    Peptide vaccines against group A streptococci

    THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 8420620

    Induced internalization of surface receptors

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 8420650

    Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP)

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Apr 16 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 11 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. CA 2852995

    COMPOSITION OPHTALMIQUE QUI CONTIENT DU BROMFENAC PRESENTANT UNE BIODISPONIBILITE ACCRUE

    BAUSCH & LOMB [US] · Granted Thu Apr 18 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Apr 13 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 8426574

    Identification of astrovirus VA1 associated with gastroenteritis in humans

    The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 8426474

    Antimicrobial wash and carrier solutions and uses thereof

    Teva Animal Health, Inc. · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 8426449

    Aminoalkylphenyl antagonists of prostaglandin D2 receptors

    Panmira Pharmaceuticals, LLC · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 8426433

    Anticoagulant compounds, pharmaceutical compositions on their basis to treat thrombotic conditions, and plasma-substituting solution to correct hypercoagulation defects of hemodilution

    Obschestvo S Ogranichennoi Otvetsttvennoctiyu “Bionika” · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 8426425

    Aminopyrimidines useful as inhibitors of protein kinases

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 8426359

    Inhibitors of serine proteases, particularly HCV NS3-NS4A protease

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 8425907

    Methods for treating pruritus by administering an antibody that specifically binds human PAR2

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 8426461

    Orally dispersible tablet

    Takeda Pharmaceutical Company Limited · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 8426365

    Method of treating or preventing tissue deterioration, injury or damage due to congestive heart failure

    REGENERX BIOPHARMACEUTICALS, INC. · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 8425459

    Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent

    Lutonix, Inc. · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 8425446

    Selective cytopheresis devices and related methods

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 8425445

    Selective cytopheresis devices and related methods thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 8425447

    Selective cytopheresis devices and related methods thereof

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 8425492

    In vivo device, system and usage thereof

    Julius-Maximilians-Universitat Wurzburg · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 8425653

    Plasmon mediated photoinduced synthesis of silver triangular bipyramids

    Northwestern University · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 8426179

    Synthetic peptide and peptide conjugates and related tissue coupling methods via transglutaminase enzyme

    Northwestern University · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 8426385

    Pharmaceutical composition comprising cyclodextrin paclitaxel inclusion and preparation method thereof

    Hainan Hdeton Science and Technology Co., Ltd. · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 8426188

    Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof

    The Board of Regents of the University of Texas System · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 8425933

    Abuse-resistant oral dosage forms and method of use thereof

    Elite Laboratories, Inc. · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 8426379

    POT1 alternative splicing variants

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 8426414

    Modulators of G protein-coupled receptor 88

    LEXICON PHARMACEUTICALS, INC. · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 8426426

    Gyrase inhibitors and uses thereof

    Vertex Pharmaceuticals Incorporated · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 8426432

    Inhibitors of dihydrofolate reductase with antibacterial antiprotozoal, antifungal and anticancer properties

    UNIVERSITY OF CONNECTICUT · Granted Tue Apr 23 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Apr 18 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2033?

1,330 published patents in our USPTO index have expiration dates falling in calendar year 2033.