Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2033

Annual patent cliff calendar for 2033 — US pharmaceutical patents by expiration date.

Patents
1,330

Quick answer

1,330 indexed pharmaceutical patents have expiration dates in 2033. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 8591891

    Monoclonal antibodies against ANGPTL4

    LEXICON PHARMACEUTICALS, INC. · Granted Tue Nov 26 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 21 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. CA 2874019

    MELANGE GAZEUX NO/AZOTE A TENEUR ELEVEE EN NO POUR TRAITER LES DETRESSES RESPIRATOIRES HYPOXEMIANTES SEVERES

    AIR LIQUIDE SANTE INT [FR] · Granted Thu Nov 28 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Nov 23 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 8597946

    Enhanced dendritic cells for cancer immunotherapy

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 8598170

    Dual-acting oxazole antihypertensive agents

    Theravance, Inc. · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. US 8598203

    Treatment of Crohn's disease with laquinimod

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 8598316

    Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies

    The Regents of the University of California · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 8597876

    Method of treating HIV infection

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 8598364

    Oligomer-protease inhibitor conjugates

    Nektar Therapeutics · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 8598361

    Process for preparing 5-fluoro-1H-pyrazolo [3,4-B] pyridin-3-amine and derivatives therof

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 8598322

    Anti CEACAM1 antibodies and methods of using same

    TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 8598321

    Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins

    The Regents of the University of California · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 8598333

    SiRNA silencing of genes expressed in cancer

    Alnylam Pharmaceuticals, Inc. · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 8598312

    Inhibitors of antigen presentation by MHC class II molecules

    Provid Pharmaceuticals Inc. · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 8598313

    Compositions for ameliorating cell proliferative disorders and methods of making and using them

    The Regents of the University of California · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 8598226

    Fused cyclic compounds

    Takeda Pharmaceutical Company Limited · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 8598205

    Modulators of cystic fibrosis transmembrane conductance regulator

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 8598210

    Prolyl hydroxylase inhibitors and methods of use

    Akebia Therapeutics, Inc. · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 8598174

    Pyridazinones, method of making, and method of use thereof

    GILEAD CONNECTICUT, INC. · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 8598191

    Controlled release compositions of gamma-hydroxybutyrate

    Supernus Pharmaceuticals, Inc. · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 8598181

    Modulators of ATP-binding cassette transporters

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 8598164

    Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 8598154

    Pyridyl-amine fused azadecalin modulators

    Corcept Therapeutics Incorporated · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 8598139

    Lipid formulated dsRNA targeting the PCSK9 gene

    Alnylam Pharmaceuticals, Inc. · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 8597948

    Cloned biological material medical device and method thereof

    FIRST PRINCIPLES, INC. · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 8598149

    Optimizing mifepristone levels in plasma serum of patients suffering from mental disorders treatable with glucocorticoid receptor antagonists

    Corcept Therapeutics Incorporated · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. US 8598133

    Methods for treating pain

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 8598121

    Variants of C-type natriuretic peptide

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 8597666

    Compressed solid dosage form manufacturing process well-suited for use with drugs of low aqueous solubility and compressed solid dosage forms made thereby

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 8597883

    Biomarkers for cancer-related fatigue and use thereof

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 8597898

    Fusion polypeptides capable of activating receptors

    REGENERON PHARMACEUTICALS, INC. · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 8597660

    Therapeutic approach to neurodegenerative disorders using a TFP5-peptide

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 8597633

    Subcutaneous delivery of poly(oxazoline) conjugates

    Serina Therapeutics, Inc. · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 8597616

    Dry powder drug delivery formulations, methods of use, and devices therefore

    The Board of Regents of the University of Texas System · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 8597655

    Recombinant fusion protein and polynucleotide construct for immunotoxin production

    The Medical Research, Infrastructure and Health Services Fund of the Tel-Aviv Medical Center · Granted Tue Dec 03 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Nov 28 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 8604058

    4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds

    Theravance, Inc. · Granted Tue Dec 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 8604023

    1,4-benzodiazepinone compounds and their use in treating cancer

    THE REGENTS OF THE UNIVERSITY OF MICHIGAN · Granted Tue Dec 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 8604203

    Modulators of cystic fibrosis transmembrane conductance regulator

    Vertex Pharmaceuticals Incorporated · Granted Tue Dec 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 8603468

    Neutralization of HCV

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Dec 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 8604064

    Process for the preparation of roflumilast

    TAKEDA GMBH · Granted Tue Dec 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 8603808

    Leishmania vaccine using sand fly salivary immunogen

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Dec 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 8603978

    Use of muramyl dipeptide (MDP) for treating inflammation

    The United States of America, as represented by the Secretary, Department of Health and Humand Services · Granted Tue Dec 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 8604244

    Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives

    REVIVA PHARMACEUTICALS, INC. · Granted Tue Dec 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 8604033

    Preparation of 4-amino-thiazoles and 3-amino-1,2,4-thiadiazoles and their use as allosteric modulators of metabotropic glutamate receptors

    Addex Pharma, S.A. · Granted Tue Dec 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 8603462

    Stem-cell, precursor cell, or target cell-based treatment of multi-organ failure and renal dysfunction

    The United States of America—Department of Veterans Affairs · Granted Tue Dec 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 8604074

    Pro-neurogenic compounds

    The Board of Regents of the University of Texas System · Granted Tue Dec 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 8603819

    Compositions and methods for generating musculoskeletal tissue

    The Regents of the University of California · Granted Tue Dec 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 8604011

    Therapy for treatment of chronic degenerative brain diseases and nervous system injury

    The Regents of the University of California · Granted Tue Dec 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 8603456

    Method of treating hair loss with compositions containing interleukin-1

    United Technologies UT AG · Granted Tue Dec 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Dec 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2033?

1,330 published patents in our USPTO index have expiration dates falling in calendar year 2033.