Wednesday, June 10, 2026

Intelligence · Patents

Patents expiring in 2033

Annual patent cliff calendar for 2033 — US pharmaceutical patents by expiration date.

Patents
1,330

Quick answer

1,330 indexed pharmaceutical patents have expiration dates in 2033. Browse by soonest expiry with links to assignee companies and related drugs.

  1. US 8530245

    Methods and compositions related to acetylocholine receptor conjugates

    The Board of Regents of the University of Texas System · Granted Tue Sep 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  2. US 8529907

    Methods of treating ophthalmic disorders

    TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. · Granted Tue Sep 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  3. US 8529885

    AAV vectors for in vivo gene therapy of rheumatoid arthritis

    ACADEMISCH MEDISCH CENTRUM · Granted Tue Sep 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  4. US 8529882

    Peptidomimetic protease inhibitors

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 10 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 05 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  5. WO 2013133980

    DÉRIVÉS NITROXY DE STÉROÏDES DOUX

    BAUSCH & LOMB [US] · Granted Thu Sep 12 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Sep 07 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  6. US 8536165

    Azabiphenylaminobenzoic acid derivatives as DHODH inhibitors

    Almirall, S.A. · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  7. US 8536132

    Lymphatic zip codes in tumors and pre-malignant lesions

    The Regents of the University of California · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  8. US 8535639

    Trifunctional imaging agent for monoclonal antibody tumor-targeted imaging

    The United States of America as Represented by the Secretary of the Department of Health and Human Services · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  9. US 8535260

    Devices, systems, and methods for localized drug delivery

    Compass Therapeutics LLC · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  10. US 8535656

    Amphiphilic polymer-protein conjugates and methods of use thereof

    BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  11. US 8535689

    Identification of bacterial autoinducer and use in treating bacterial pathogenicity

    THE TRUSTEES OF PRINCETON UNIVERSITY · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  12. US 8535890

    Methods to determine immunogenicity of humanized anti-tag 72 CC49 antibodies

    The United of America as represented by the Secretary of the Department of Health and Human Services · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  13. US 8535667

    Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers

    PRECISION BIOLOGICS, INC. · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  14. US 8535687

    Smallpox DNA vaccine and the antigens therein that elicit an immune response

    Inovio Pharmaceuticals, Inc. · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  15. US 8535712

    Radiation sensitive liposomes

    Arizona Board of Regents on Behalf of the University of Arizona · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  16. US 8536133

    Selective high-affinity polydentate ligands and methods of making such

    The Regents of the University of California · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  17. US 8536148

    Disabling autophagy as a treatment for lysosomal storage diseases

    The United States of America, as represented by the Secretary, Department of Health and Human Services · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  18. US 8536136

    Inhibitors of serine proteases, particularly HCV NS3-NS4A protease

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  19. US 8536147

    Antibacterial antisense oligonucleotide and method

    Sarepta Therapeutics, Inc. · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  20. US 8536149

    TRPM-2 antisense therapy

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  21. US 8536363

    Compounds and methods for delivery of prostacyclin analogs

    United Therapeutics Corporation · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  22. US 8536206

    Process for the preparation of roflumilast

    TAKEDA GMBH · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  23. US 8536213

    Oligomer-dantrolene conjugates and related compounds

    Nektar Therapeutics · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  24. US 8536335

    Crystalline forms of an 8-azabicyclo[3.2.1]octane compound

    Theravance, Inc. · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  25. US 8536195

    Bicyclic derivatives as modulators of ion channels

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 17 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 12 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  26. CA 2859273

    POLYMERES CATIONIQUES A BASE DE GLYCOGENE

    ACRAF [IT] · Granted Thu Sep 19 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Wed Sep 14 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  27. US 8541024

    Film-coated scored tablet

    Takeda Pharmaceutical Company Limited · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  28. US 8541417

    Poly (ADP-ribose) polymerase (PARP) inhibitors

    Takeda Pharmaceutical Company Limited · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  29. US 8541458

    Oxabicycloheptanes and oxabicycloheptenes, their preparation and use

    Lixte Biotechnology, Inc. · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  30. US 8541375

    Glycopeptide phosphonate derivatives

    Theravance, Inc. · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  31. US 8541373

    BChE albumin fusions for the treatment of cocaine abuse

    TEVA PHARMACEUTICAL INDUSTRIES, LTD. · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  32. US 8541185

    Method of predicting responsiveness to autologous adoptive cell transfer therapy

    TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  33. US 8541221

    Primate T-lymphotropic viruses

    The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  34. US 8540997

    Complement receptor 1 and 2 fusion proteins

    The Regents of the University of Colorado, a Body Corporate · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  35. US 8541203

    Activatable binding polypeptides and methods of identification and use thereof

    The Regents of the University of California · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  36. US 8541025

    Co-crystals and pharmaceutical formulations comprising the same

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  37. US 8541182

    Biological marker for inflammation

    CAN-FITE BIOPHARMA LTD. · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  38. US 8541371

    Treatment of conditions related to cecal ligation shock

    The Regents of the University of California · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  39. US 8541231

    Elimination of N-glycolylneuraminic acid from animal products for human use

    The Regents of the University of California · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  40. US 8541403

    Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) for use in treatment of diseases associated with a PTEN deficiency

    BIOMARIN PHARMACEUTICAL INC. · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  41. US 8541445

    Pyrazolopyridines

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  42. US 8541453

    Modulators of ATP-binding cassette transporters

    Vertex Pharmaceuticals Incorporated · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  43. US 8541456

    Roflumilast for the treatment of diabetes mellitus type 2

    TAKEDA GMBH · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  44. US 8541451

    Crystalline freebase forms of a biphenyl compound

    Theravance, Inc. · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  45. US 8541597

    Process for preparing biphenyl imidazole compounds

    Theravance, Inc. · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  46. US 8541608

    Method for preparing a polymer conjugate

    Nektar Therapeutics · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  47. US 8541482

    Removable multilayer nail coating system and methods therefore

    Creative Nail Design Inc. · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted
  48. US 8541548

    Compounds and methods for reversible modification of biologically active molecules

    Arrowhead Madison, Inc. · Granted Tue Sep 24 2013 00:00:00 GMT+0000 (Coordinated Universal Time) · Expires Mon Sep 19 2033 00:00:00 GMT+0000 (Coordinated Universal Time)

    granted

Frequently asked questions

How many pharma patents expire in 2033?

1,330 published patents in our USPTO index have expiration dates falling in calendar year 2033.